Lab of Dr. Claudia Fischbach @CornellBME. We apply engineering principles to understand how tissue microenvironments influence cancer. Tweets by lab members.
Ithaca, NY
Joined August 2022
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Preprint alert! Excited to share our new manuscript from @CornellBME @GarrettBeeghly examining how the size of fat cells, or adipocytes, impacts breast cancer risk. We found that larger adipocytes promote aggressive behavior in tumor cells. 1/5 biorxiv.org/content/10.1101/…
Fischbach Lab retweeted
As an undergraduate researcher, Yiwei Yan ’25 studied how breast cancer cell growth is regulated in bone by investigating how bone mineral content and tumor-secreted factors influence the growth of mesenchymal stem cells.
ALT Yiwei in the lab in Weill Hall
Fischbach Lab retweeted
Hypertrophic adipocytes increase extracellular vesicle-mediated lipid release and reprogram breast cancer cell metabolism biorxiv.org/content/10.1101/… #biorxiv_cellbio
Ultimately, our findings suggest that larger adipocytes are a distinct cell population within adipose tissue and increase lipid transfer to invading cancer cells. As a result, we propose that adipocyte size could be a valuable prognostic biomarker for breast cancer patients. 5/5
In a published cohort of mastectomy patients, we found that average adipocyte size predicted dyslipidemia and circulating triglycerides more than BMI. These results suggest that altered lipid release by larger adipocytes may also have implications for whole body metabolism. 4/5
Functionally, larger adipocytes increase a non-canonical, vesicle-mediated mode of lipid release versus lipolysis. This shift promotes lipid transfer to nearby breast cancer cells, increasing their migration and proliferation in a manner dependent on fatty acid metabolism. 3/5
Here, we developed methods to sort and culture primary adipocytes isolated from the same adipose tissue. We determined larger adipocytes are transcriptionally distinct from smaller donor-matched cells and are enriched for gene sets related to altered lipid processing. 2/5
Fischbach Lab retweeted
Thanks @FischbachLab for accepting our invitation and giving an excellent keynote to kick off the 2025 GRS Physical Science of Cancer 🙏! #POC_GRC_2025
grc.org/physical-science-of-…
Check out our latest publication in @Biomaterials_ on how mineralized scaffolds alter the microenvironmental composition of pre-clinical tumor models: sciencedirect.com/science/ar…
Scaffold design and choice of animal model drastically affect tissue formation and cellular complexity impressively shown in our new @Biomaterials_ paper by @Matt_AWhit and @mantri_madhav with @IwijnDeVlaminck @CornellBME
sciencedirect.com/science/ar…
Fischbach Lab retweeted
Feeling extremely grateful to have completed my PhD with so much support from @CornellBME, @FischbachLab, and my fantastic advisor. I can't imagine the past six years anywhere else. Excited to see what is next! #PhDone
Congratulations @GarrettBeeghly on a fantastic defense and significantly advancing our understanding of adipocytes and their role in cancer! Well done Dr. B! @CornellBME @FischbachLab
Fischbach Lab retweeted
Congratulations @GarrettBeeghly on a fantastic defense and significantly advancing our understanding of adipocytes and their role in cancer! Well done Dr. B! @CornellBME @FischbachLab
Fischbach Lab retweeted
Come join us!
We're Hiring! Seeking a Tenure Track Faculty Position in Biomedical Engineering, @Cornell @CornellEng @CornellBME #BME. Learn more, apply: academicjobsonline.org/ajo/j…
Fischbach Lab retweeted
Couldn’t have asked for a more perfect day for @FischbachLab apple picking @CornellBME
Going to the @BMESociety Annual Meeting in Baltimore next week? Check out these @FischbachLab presentations and posters! And stop by the @CornellBME booth to learn more about our graduate MEng and PhD programs
Thank you to @LammerdingLab and @FischbachLab bakers and everyone else who made the fundraiser our most successful year yet! We raised over $1100 for @CancerResource. Make sure to check out all the amazing work the CRC does at crcfl.net
Fischbach Lab retweeted
Made chocolate caneles for our annual @CancerCornell bake sale fundraiser for the @CancerResource Center of the Finger Lakes! Stop by Weill Hall today for some freshly baked goods and to support a great cause 👨🍳
Fischbach Lab retweeted
Ever had Gochujang cookies? Come and get some (or other delicious items) today at bake sale in Weill Hall @CornellBME in support of @CancerResource organized by @FischbachLab @LammerdingLab
Fischbach Lab retweeted
Members of the @FischbachLab and the @LammerdingLab out in force at today’s Walkathon and 5K run in support of the @CancerResource
Fischbach Lab retweeted
We're Hiring! Seeking a Tenure Track Faculty Position in Biomedical Engineering, @Cornell @CornellEng @CornellBME #BME. Learn more, apply: academicjobsonline.org/ajo/j…
