Using genomics to study neurodegenerative diseases & neurodevelopmental disorders to improve diagnosis & treatment. Focus on cerebellar ataxia.
Joined January 2012
- Tweets171
- Following99
- Followers291
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Brent Fogel retweeted
"Vanishing White Matter" (VNM) is a type of #leukodystrophy that affects axons in our nervous system. There are currently no approved treatments.
Dr. Brent Fogel (@FogelLab) is looking into establishing a protocol for clinical trials on this disease.
pubmed.ncbi.nlm.nih.gov/3759…
Our latest publication highlighting the need for improving patient access to #exome sequencing @UCLANeurology @NAF_Ataxia @UCLAHealth
Spinocerebellar #ataxia type 14 (#SCA14) in an #Argentinian family. This case report expands the #global presence of this neurological disorder
@FogelLab
jmedicalcasereports.biomedce…
Brent Fogel retweeted
This @iScience_CP study with Kathie Ngo and Drs. @HinmanLabUCLA and @FogelLab identifies targetable region-specific vulnerabilities to neurological disease mediated by oligodendrocytes.
#neurotwitter
sciencedirect.com/science/ar…
Read from @fogellab "multiWGCNA: an R package for deep mining gene co-expression networks in multi-trait expression data" #BMCBioInformatics for study of disease-associated gene networks across time or space bmcbioinformatics.biomedcent… @TommasiniDario @UCLANeurology @UCLAHealthNews
"Alterations in oligodendrocyte transcriptional networks reveal region-specific vulnerabilities to neurological disease" in @iScience_CP sciencedirect.com/science/ar…
@TommasiniDario @rachelgiulia @Kathie0309 collaboration with @HinmanLabUCLA @NAF_Ataxia @UCLAHealthNews @UCLANeurology
Read @FogelLab picks for the Best Advances in Neurogenetics in 2022 in @NeurologyToday
including detection of repeat expansions using genome sequencing and novel genetic interactions between SCA17 & SCA48
@UCLANeurology @AANmember @NAF_Ataxia
Check out @NeurologyToday's Best Advances! The annual feature highlights the most noteworthy advancements across #neurology subspecialties and areas of practice. bit.ly/3HoWMCl
#NeuroTwitter
Brent Fogel retweeted
New! Rafehi et al. identify an intronic FGF14 repeat expansion in adult-onset ataxia
bit.ly/3BmiyD3
Can you guess the diagnosis? Excellent case report by Dr. Molly Fensterwald (with contributions from Drs. Noriko Salamon, Joshua Buyers, Harry Vinters, and @FogelLab ) @UCLANeurology @UCLAHealth @AJNR
#AJNRcow >> August 4, 2022 >> A 45-year-old woman with a history of focal segmental glomerulosclerosis status post kidney transplant on immunosuppression presents with subacute weakness, paresthesias, & a shaking episode of her left arm. View the case at ow.ly/fXcA50KcX5F.
Brent Fogel retweeted
Dr. Brent Fogel @FogelLab was quoted in a @NeurologyToday article on how advances in #genetics #research of the past 20 years have changed our understanding of cerebellar ataxia.
uclahealth.org/neurology/dr-…
@FogelLab discusses how #exome sequencing has advanced care in cerebellar #ataxia @NeurologyToday @NAF_Ataxia @UCLANeurology #RareDisease journals.lww.com/neurotodayo…
Think about the future of #ataxia therapies. Read "Paving the Way Toward Meaningful Trials in Ataxias: An Ataxia Global Initiative Perspective" movementdisorders.onlinelibr… @NAF_Ataxia @UCLANeurology @MDJ_Journal @ataxia_global
Brent Fogel retweeted
To close out #BrainAwarenessWeek, we have a thread by Dr. Brent Fogel @FogelLab on @UCLA and neurogenetics! 🧠🧬
Brent Fogel retweeted
The @UCLANeurology Clinical Neurogenomics Research Center helps connect #patients with exciting #research studies such as the development of new biomarkers for #ParkinsonsDisease and related disorders by Drs. Gal Bitan, Brent Fogel, Beate Ritz @beate_ritz, and Jeff Bronstein.
Brent Fogel retweeted
Dr. Brent Fogel in the @UCLA Neurogenetics #Clinic cares for patients with X-linked adrenoleukodystrophy.
X-linked adrenoleukodystrophy is the most common leukodystrophy, genetic disorders that damage the white matter of the #brain, affecting nearly 1 of 15,000 people in the US.
Brent Fogel retweeted
Did you know @UCLANeurology has the largest clinical Ataxia Center in the West?
#UCLA is also a leader in #research and clinical trials on genetic ataxias thanks to the efforts of Drs. Susan Perlman, Brent Fogel, Jessica Rexach @RexachLab, and Dan Geschwind @GeschwindLab.
Brent Fogel retweeted
At UCLA Health, Dr. Brent Fogel is transforming the future of #Neuroscience by identifying the unique genetics of patients to stop neurological diseases.
It's one of many ways the innovative research at UCLA Health is transforming patient care. Click below to learn more.
Brent Fogel retweeted
Best #Neurogenetics advances of 2021: Thanks to @AANmember @FogelLab @dgsomucla for sharing his picks on the UK 100,000 Genomes Project pilot study on WGS and CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis. bit.ly/3tInI9u
#NeuroTwitter
Hadjinicolaou & Ngo #SETX confirmed functionally to cause a rapidly progressive early‑onset #neurogenetic disorder w severe polyneuropathy @Fogellab collab w C Bennett Al La Spada & Grace Yoon #ALS4 @UCLANeurology @UCLAHealthNews @SickKidsNews @NAF_Ataxia rdcu.be/cDtVw
Brent Fogel retweeted
Although dystonia can occur with certain medications, it is often unknown why some people develop this and others do not. In this report we discuss the likely underlying genetic basis for medication-induced dystonia in this family. #pharmacogenetics
Wong & @Fogellab report a woman & family with acute dystonia to ondansetron, prochlorperazine, and metoclopramide. #Pharmacogenomic testing revealed the CYP2D6 enzyme *41 allele as the likely cause of the medication-induced dystonia. @UCLANeurology rdcu.be/cu6pS
