Brent Fogel (@FogelLab) header
Brent Fogel (@FogelLab) profile picture

Brent Fogel

@FogelLab

Using genomics to study neurodegenerative diseases & neurodevelopmental disorders to improve diagnosis & treatment. Focus on cerebellar ataxia.

fogellab.neurology.ucla.edu/
Joined January 2012
  • Tweets171
  • Following99
  • Followers291
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Photo by Brent Fogel (@FogelLab)Photo by Brent Fogel (@FogelLab)Photo by Brent Fogel (@FogelLab)Photo by Brent Fogel (@FogelLab)Photo by Brent Fogel (@FogelLab)Photo by Brent Fogel (@FogelLab)Photo by Brent Fogel (@FogelLab)Photo by Brent Fogel (@FogelLab)Photo by Brent Fogel (@FogelLab)Photo by Brent Fogel (@FogelLab)
"Vanishing White Matter" (VNM) is a type of #leukodystrophy that affects axons in our nervous system. There are currently no approved treatments. Dr. Brent Fogel (@FogelLab) is looking into establishing a protocol for clinical trials on this disease. pubmed.ncbi.nlm.nih.gov/3759…
Image from UCLA Neurology (@UCLANeurology)
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This @iScience_CP study with Kathie Ngo and Drs. @HinmanLabUCLA and @FogelLab identifies targetable region-specific vulnerabilities to neurological disease mediated by oligodendrocytes. #neurotwitter sciencedirect.com/science/ar…
Image from UCLA Neurology (@UCLANeurology)
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Brent Fogel retweeted
AJHG (@AJHGNews) profile picture
AJHG@AJHGNews8 Dec 2022
New! Rafehi et al. identify an intronic FGF14 repeat expansion in adult-onset ataxia bit.ly/3BmiyD3
An intronic GAA repeat expansion in FGF14 causes the autosomal-dominant adult-onset ataxia SCA27B...

An intronic GAA repeat expansion in FGF14 causes the autosomal-dominant adult-onset ataxia SCA27B...

Pathogenic repeat expansions (RE) cause an array of neurogenetic disorders including cerebellar ataxia. While traditionally difficult to identify, new genomic tools and bioinformatic analyses are...

cell.com
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Dr. Brent Fogel @FogelLab was quoted in a @NeurologyToday article on how advances in #genetics #research of the past 20 years have changed our understanding of cerebellar ataxia. uclahealth.org/neurology/dr-…
Image from UCLA Neurology (@UCLANeurology)
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To close out #BrainAwarenessWeek, we have a thread by Dr. Brent Fogel @FogelLab on @UCLA and neurogenetics! 🧠🧬
Image from UCLA Neurology (@UCLANeurology)
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The @UCLANeurology Clinical Neurogenomics Research Center helps connect #patients with exciting #research studies such as the development of new biomarkers for #ParkinsonsDisease and related disorders by Drs. Gal Bitan, Brent Fogel, Beate Ritz @beate_ritz, and Jeff Bronstein.
Image from UCLA Neurology (@UCLANeurology)
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Dr. Brent Fogel in the @UCLA Neurogenetics #Clinic cares for patients with X-linked adrenoleukodystrophy. X-linked adrenoleukodystrophy is the most common leukodystrophy, genetic disorders that damage the white matter of the #brain, affecting nearly 1 of 15,000 people in the US.
Image from UCLA Neurology (@UCLANeurology)
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Did you know @UCLANeurology has the largest clinical Ataxia Center in the West? #UCLA is also a leader in #research and clinical trials on genetic ataxias thanks to the efforts of Drs. Susan Perlman, Brent Fogel, Jessica Rexach @RexachLab, and Dan Geschwind @GeschwindLab.
Image from UCLA Neurology (@UCLANeurology)
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Brent Fogel retweeted
UCLA Health (@UCLAHealth) profile picture
UCLA Health
@UCLAHealth14 Mar 2022
At UCLA Health, Dr. Brent Fogel is transforming the future of #Neuroscience by identifying the unique genetics of patients to stop neurological diseases. It's one of many ways the innovative research at UCLA Health is transforming patient care. Click below to learn more.

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Best #Neurogenetics advances of 2021: Thanks to @AANmember @FogelLab @dgsomucla for sharing his picks on the UK 100,000 Genomes Project pilot study on WGS and CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis. bit.ly/3tInI9u #NeuroTwitter
Image from Neurology Today (@NeurologyToday)
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Brent Fogel retweeted
Brent Fogel (@FogelLab) profile picture
Brent Fogel@FogelLab27 Aug 2021
Replying to @UCLANeurology
Although dystonia can occur with certain medications, it is often unknown why some people develop this and others do not. In this report we discuss the likely underlying genetic basis for medication-induced dystonia in this family. #pharmacogenetics
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This study evaluated whether α-syn in exosomes could distinguish between #Parkinsons disease and multiple system atrophy, with Drs. Suman Dutta, Kimberly Paul, Darice Wong, Susan Perlman, @FogelLab, Jeff Bronstein, @beate_ritz, & Gal Bitan. link.springer.com/article/10…
α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers...

α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers...

Acta Neuropathologica - The diagnosis of Parkinson’s disease (PD) and atypical parkinsonian syndromes is difficult due to the lack of reliable, easily accessible biomarkers. Multiple system...

link.springer.com
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Today at 2pm EST @FogelLab from @UCLANeurology presents our #collaboration in @hmg_journal on #oligodendrocytes in #tauopathy during S13 #AANAM @AANAM. Good time for a tweetorial on our work… 1/n
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Also @FogelLab presenting our #Collaboration on #gene network disruption by miRNA-142-3p in tauopathy @UCLANeurology @HinmanLabUCLA
UCLA Neurology (@UCLANeurology) profile pictureUCLA Neurology@UCLANeurology19 Apr 2021
UCLA Neurology speakers at the AAN Virtual Annual Meeting #AANAM include Rebecca Reyes; Geoff White; Andrew M. Wilson, MD, MBA; and Charles C. Flippen, II, MD, FAAN.
Image from UCLA Neurology (@UCLANeurology)
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Oligodendrocytes are implicated in multiple #brain diseases including #dementia. Dr. Jason Hinman @HinmanLabUCLA, Kathie Ngo, and Dr. Brent Fogel @FogelLab transcriptionally profiled adult mature oligodendrocytes from different regions of the #CNS. academic.oup.com/hmg/advance…
Image from UCLA Neurology (@UCLANeurology)
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7+ years in works, survived a scoop, and now finally out! TRAP-seq from mature #oligodendrocytes identifies shared #gene networks in #tau neurodegeneration regulated by miR-142-3p. @FogelLab @UCLANeurology @mssociety #myelination academic.oup.com/hmg/advance…
miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy

miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy

Abstract. Oligodendrocytes exist in a heterogenous state and are implicated in multiple neuropsychiatric diseases including dementia. Cortical oligodendroc

academic.oup.com
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Brent Fogel retweeted
GeneDx (@GeneDx) profile picture
GeneDx@GeneDx1 Feb 2021
GeneDx collaboration led by @FrankDiazMDPhD @FogelLab @shrimishra @UCLANeurology @UDNConnect expands the NUDT2-related phenotype by describing a novel frameshift variant in 2 families with sensorimotor polyneuropathy & intellectual disability #raredisease bit.ly/3lFdsai
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A recent study by Shaweta Khosa, Drs. Robert Freundlich, Stanley F. Nelson and Brent Fogel @FogelLab found that the NUDT2 gene causes intellectual disability and sensorimotor polyneuropathy. onlinelibrary.wiley.com/doi/…
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Yay its @FogelLab chairing flash talk IV @ataxia_global #AtaxiaGlobal2020 #Ataxia #kNOwATAXIA
Image from Ataxia_aware CIO 1184030 (previously Ataxia_and_me (@Ataxia_aware)
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Thanks to @movedisorder for the opportunity to present about spastic-ataxias today. Great session with @teiveads, @FogelLab and Barsottini. Thanks to @mayelarv and Pedroso for the questions! #MDSCongress
Image from Carlos Henrique F Camargo (@chcamargoneuro)
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