A lot of work behind this one!
Huge thanks to Coline Portet, Flora Thellier and all our collaborators.
More broadly, our findings extend the role of the claustrum beyond cortical-state regulation.
It may provide a route through which distributed cortical dynamics are coordinated with hippocampal output during sleep, with consequences for memory consolidation.
This motif is distributed across prefrontal cortex, retrosplenial cortex and subiculum, and is accompanied by transient changes in coherence, gamma-burst synchrony, phase alignment and directed interactions.
We then activated this pathway during post-learning sleep.
Behaviorally: memory consolidation improves.
Physiologically: a highly stereotyped network motif appears: a brief gamma-rich Up state, followed by a coordinated Down state.
We turned to a population of claustral neurons projecting to the subicular complex, a major hippocampal output node.
These neurons are strongly recruited during slow-wave sleep, and their endogenous activity is organized around coordinated cortical and subicular Up/Down states.
A few years ago, with Jesse Jackson and colleagues, we found that the claustrum can shape cortical dynamics during NREM sleep and promote memory consolidation.
doi.org/10.1016/j.celrep.202…
That left us wondering: does its role during sleep extend beyond the cortex?
Really happy to finally share this one 🎉
Our new preprint is now on bioRxiv:
biorxiv.org/content/10.64898…
A short thread on the story behind it 🧵
We've moved to Bluesky! Follow our new adventure at @funsycnrs.bsky.social
Come join us there for the latest updates!
FunSy retweeted
@LabLuthi uncovers a dual role of #locus @coeruleus in #sleep -> 1) its strict gatekeeper role for the sleep cycle 2) the partial brain-body arousals it generates. Powerful minds behind all this: @alejandrosoriof @GFoustoukos @CardisRomain
nature.com/articles/s41593-0…
FunSy retweeted
🎡🐁 New preprint from the team in @biorxiv_neursci !
Using a mouse model of AD, @GLM_Bouisset made a great contribution in the understanding of neural substrate for cognitive reserve 🧠🧐
🧠 New Research Alert! 🧠 Excited to announce our latest study, now live on @biorxiv_neursci!
Enriched environments have shown long-lasting cognitive benefits in Alzheimer’s models (👉10.1016/j.neurobiolaging.2012.05.013), but what drives this "cognitive reserve"? 🤔
ALT Cartoon of happy mice in an amusement park, generated by AI
Our latest is out in @TrendsNeuro ! 🧠💡 With @alyy_dodo, @Coline_Portet, and @_jesse_jackson, we propose that Claustrum activity could influence cognition by structuring the timing of cortical down states. Check it out: cell.com/trends/neuroscience…"
Fantastic work by an amazing student. Thanks @aguilera_matth for your outstanding work! If you're looking for a talented postdoc candidate, keep an eye out—he’ll be on the market soon…
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Congrats to the @CharletLab team!
biorxiv.org/content/10.1101/…
What an outstanding work! 🎉
Our stellar student, @Coline_Portet , will present at #sfn2024 ! Interested in the claustrum’s role in sleep-dependent memory consolidation? Catch her Wednesday (PSTR424.09/U14). This work is a great collaboration with @SychYaroslav and @_jesse_jackson
FunSy retweeted
I am looking for a Coordinator Office to be in charge of the Erasmus Mundus IMAGEIN, a Consortium of 5 Universities from 4 European Countries. Please RT. Thanks in advance.
linkedin.com/jobs/view/40302…
FunSy retweeted
Très heureux et fier d'Elodie qui fait un travail extraordinaire pour lutter contre la douleur du nouveau né prématuré! @euridol @FunSyCNRS @CNRS_Alsace @fond_unistra
🏅 Prix de la bourse IDE Réa remis à Elodie Rabatel par @ClaireFazilleau, présidente du comité IDE Réa, pour son sujet " Antalgie du nouveau-né prématuré par interventions maternelles lors d’un prélèvement veineux" #SFAR2024
