Professor of Cancer Epidemiology, UCL. Research focus on improving the diagnostic process and outcomes for cancer patients. Ts own views; RTs views of others
UK
Joined July 2012
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1/12 With colleagues in 14 jurisdictions in 6 countries we have just published a study on the predictors and consequences of cancer diagnosis within 30 days after an emergency hospital admission (=emergency presentation) in @TheLancetOncol thelancet.com/pdfs/journals/… A🧵:
YoryosLyratzopoulos retweeted
From measurement to improvement: new evidence on reducing emergency cancer diagnoses 🎯
Nearly 25% of cancer patients are diagnosed in emergency settings, and these patients face significantly worse outcomes, even after accounting for disease stage.
A new editorial by @glyratzopoulos and colleagues discuss this finding and present a new taxonomy of evidence on diagnosis of cancer as an emergency
Read the full editorial to learn how diagnostic process evaluation can drive meaningful improvements here: bit.ly/4b9hYei
Read the original article by Khalaf et al here: bit.ly/4sJYH94
YoryosLyratzopoulos retweeted
Older men with new-onset fatigue are relatively likely to have an undetected cancer, compared to other cohorts.
Figure: 1-year disease risk in men bjgp.org/content/early/2024/… @BexKWhite @MattBarclay89 @Glyratzopoulos @UCL_BSH @UCL_IHI @BrianDNicholson @SpirosDenaxas @DrMeenaRafiq
YoryosLyratzopoulos retweeted
Congratulations on winning one of the best posters @DrMeenaRafiq @RCGPAC #RCGPAC – at Liverpool, England
ALT Dr Rafiq presents her research
@DrMeenaRafiq presents her work on the value of blood tests in detecting cancers for patients with new abdominal symptoms using blood tests
Exciting research likely to change @NICEComms guidelines!
See the paper: journals.plos.org/plosmedici…
#rcgpac
ALT Meena Rafiq presents her research
ALT Conclusions
YoryosLyratzopoulos retweeted
Great to hear the primary care cancer OG tag team tell us about the early diagnosis of cancer @drtomround @SamMerriel @richarddneal
Best4 trial: fundingawards.nihr.ac.uk/awa…
Prostate cancer trial: prostatecanceruk.org/researc…
MCED: mced.info/
#rcgpac – at Liverpool, England
ALT Dr Thomas Round presents
ALT Sam Merriel presents data on early diagnosis of cancer
ALT Prof Richard Neal presents data on MCEDs
ALT What is important for GPs to know now and in the future
YoryosLyratzopoulos retweeted
I’m thrilled to receive a @CRUKresearch International Alliance for Cancer Early Detection (ACED) - Pathway Award for the ICEBERG project 🧊: Improving Cancer Early detection using Blood tEst Results in General practice 🩸 📈 👩🏻⚕️ 🦠
@UCL_BSH @GLyratzopoulos @Cambridge_Uni
YoryosLyratzopoulos retweeted
Nonspecific symptoms pose a diagnostic challenge to primary care cancer diagnosis and can result in repeat pre-diagnostic GP presentations. New interventions are needed to help pick up these cancers earlier. @drtomround #RCGPAC2024 @GLyratzopoulos
3/3 A third of EP patients were previously referred urgently; faster specialist assessment may have resulted in non-EP diagnosis in some. EP patients who were also emergency-referred had 9-fold higher mortality within a month post-diagnosis, compared to non-EP patients @CRUKHCPs
2/3 “Predictors and consequences of different pathways to emergency diagnosis of cancer in England: Evidence from linked national audit and cancer registration data" @RuthSwann, @GLyratzopoulos, @Gregrubin4, @EllissBrookes, Sean McPhail” @CancerEpid pubmed.ncbi.nlm.nih.gov/3916…
1/3 With colleagues @RuthSwann, @GLyratzopoulos, @Gregrubin4, @EllissBrookes, Sean McPhail we have recently published a study aiming to understand pathways to diagnosis of cancer as an emergency presentation, and their consequences, a bit more pubmed.ncbi.nlm.nih.gov/3916…
YoryosLyratzopoulos retweeted
All adults will have 1 diagnostic error in their life. It was an honour to be the Keynote speaker at the @WHO #WorldPatientSafetyDay in Budapest presenting on how to improve diagnostic safety in primary care 👩🏻⚕️
YoryosLyratzopoulos retweeted
Patients with as-yet-undetected cancer start using GP healthcare more several months before cancer diagnosis and blood tests may help to diagnose them earlier. @DrMeenaRafiq presents work from UK and Australia @CRUKHCPs #CRUKEDConference24 @UCL_BSH @VCCCAlliance
YoryosLyratzopoulos retweeted
Day 2 of #CRUKEDconference24 showcases more work from @QMUL_CCSPED @Jo_WallerPhD @Suzanne_Scott_ and ends with two great sessions led by @Katriina01 and @GLyratzopoulos
Great conference with so much thought provoking work!
Great first day at the #CRUKEDconference24 in Birmingham
Fab to see so many @QMUL_CCSPED colleagues presenting their work
YoryosLyratzopoulos retweeted
"The ED may be involved in the initial identification of cancer for 1 in 5 #patients (65y+)". New findings from US #Medicare data analysis - closely following our work linked below, highlighting concerns for population #Health and #cancer
academic.oup.com/jncics/adva… @GLyratzopoulos
YoryosLyratzopoulos retweeted
"vaccination has averted 154 million deaths"
On the 50th anniversary of WHO's Expanded Programme on Immunization, Naor Bar-Zeev & colleagues quantify the public health impact of vaccination: hubs.ly/Q02ymFn60
ALT Figure showing deaths averted, years of life saved, and years of full health gained due to vaccination. Copyright: 2024 World Health Organization; licensee Elsevier Ltd. CC BY 3.0 IGO
YoryosLyratzopoulos retweeted
New commentary @LancetRH_WPac from international collaboration with @famednusg @josemvalderas
Cross-country learning can lead to improved cancer diagnosis and outcomes for all. @QMUL_WIPH @QMUL_CCSPED @CanTest_PC
doi.org/10.1016/j.lanwpc.202…
Addressing cancer care gaps through improved early cancer diagnosis in Singapore: research priorities to inform clinical practice. sciencedirect.com/science/ar…
YoryosLyratzopoulos retweeted
People living in deprived areas are more likely to receive a colon #cancer diagnosis through emergency hospitalisation.
This study, published today in @BrJCancer, digs into the details of #inequality in cancer diagnosis.
Read more on our website
👉 bit.ly/3QIbPv9
YoryosLyratzopoulos retweeted
#Sexinequality in #bladdercancer diagnosis may be due to differences in #haematuria frequency and onset between men and women.
@GLyratzopoulos @fmw22 @JianhuaWu6 @QMUL_WIPH @QMUL_CCSPED
More in our new @BJUICompass paper: doi.org/10.1002/bco2.360
YoryosLyratzopoulos retweeted
Guideline concordance for timely chest imaging after new presentations of dyspnoea or haemoptysis in primary care: a retrospective cohort study @mmkoo12 @LukeMounce @DrMeenaRafiq @CallisterMat @HardeepSinghMD @garyabel @glyratzopoulos thorax.bmj.com/content/79/3/…
Many congratulations @DrMeenaRafiq , onwards and upwards to even greater things!👏
I’m thrilled to receive a @CRUKresearch International Alliance for Cancer Early Detection (ACED) - Pathway Award for the ICEBERG project 🧊: Improving Cancer Early detection using Blood tEst Results in General practice 🩸 📈 👩🏻⚕️ 🦠
@UCL_BSH @GLyratzopoulos @Cambridge_Uni
It has been terrific to, alongside @MattBarclay89 and Cristina Renzi, contribute to this innovative work led by @BexKWhite as part of her @ucl PhD studies. Thank you @BJGPjournal for hosting, disseminating & including in the Journal's 'top-10' papers for 2023 🙏👏
No. 10 #BJGPTop10 – Cancer risk and fatigue: tiredness plus weight loss or abdominal pain could be signs of cancer in older patients
doi.org/10.3399/BJGP.2022.03… @BexKWhite @MattBarclay89 @Glyratzopoulos @UCL_BSH