@TheLancet

Welcome to The Lancet, one of the world’s leading medical journals, published weekly since 1823.

 London, New York, Beijing
thelancet.com
Joined March 2009
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In our latest issue, a new Commission outlines 17 interlinked catastrophic threats to health & human survival between 2025 & 2100. The report provides decision-makers with a common framework for coordinated action. Read this & more: spkl.io/60117nhhU @IHME_UW @UNFPA
Cover of The Lancet's October 17, 2026 issue. Quote reads: \"This Commission offers a message of hope: however great, the health threats identified in this report can be shaped by policy action.\"

ALT Cover of The Lancet's October 17, 2026 issue. Quote reads: \"This Commission offers a message of hope: however great, the health threats identified in this report can be shaped by policy action.\"

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Adding a hormonal coil during surgery for heavy menstrual bleeding reduces future hysterectomy risk by more than half, trial finds. Find out more in The Lancet: spkl.io/60107Xx46
Research in context panel for a study published in The Lancet entitled \"Endometrial ablation plus levonorgestrel-releasing intrauterine system versus endometrial ablation alone in women with heavy menstrual bleeding in The Netherlands (MIRA2): a multicentre, open-label, randomised, controlled, superiority trial\". Copyright: 2026 Elsevier Ltd. All rights reserved.

ALT Research in context panel for a study published in The Lancet entitled \"Endometrial ablation plus levonorgestrel-releasing intrauterine system versus endometrial ablation alone in women with heavy menstrual bleeding in The Netherlands (MIRA2): a multicentre, open-label, randomised, controlled, superiority trial\". Copyright: 2026 Elsevier Ltd. All rights reserved.

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From trainee physician to CEO of @gavi, what can Dr Sania Nishtar's 30+ year career journey tell us about the future of global health? Hear her unique insights at our International Health Lecture with @acmedsci🌎 📍 London 📅 Wed Nov 4, 2026 Register: spkl.io/60117VIhD
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AI tool can predict cancer patients’ chances of survival from a single face photograph, study suggests. Find out more in @LancetDigitalH: spkl.io/60167XBzr
Research in context panel for a study published in The Lancet Digital Health entitled \"Foundation artificial intelligence models for health recognition by use of face photographs (FAHR-Face): a model development and validation study\".

ALT Research in context panel for a study published in The Lancet Digital Health entitled \"Foundation artificial intelligence models for health recognition by use of face photographs (FAHR-Face): a model development and validation study\".

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Sierra Leone has a 1 in 52 lifetime risk of maternal death — adolescent girls face the greatest risk. Join Cristina Fernandez Turienzo on 18 Nov to hear how 2YoungLives cut maternal & perinatal mortality by 48%. 👉 Register: spkl.io/60197pzPf #GlobalHealth #EvidencetoImpact
Dark blue graphic with photo of Cristina Fernandez Turienzo. White text on graphic reads: \"From Evidence to Impact: Winning Case Studies from The Lancet-Elsevier Foundation Awards, join Cristina Fernandez Turienzo, Senior Research Fellow in Matneral, Child and Adolescent Health, PI, King's College London, UK, on Wed, Nov 18, 2026 at 9am GMT/10am CET, presented in partnership with The Elsevier Foundation\". The Lancet Webinars logo appears in the bottom left corner alongside The Elsevier Foundation logo. Copyright: Elsevier Ltd.

ALT Dark blue graphic with photo of Cristina Fernandez Turienzo. White text on graphic reads: \"From Evidence to Impact: Winning Case Studies from The Lancet-Elsevier Foundation Awards, join Cristina Fernandez Turienzo, Senior Research Fellow in Matneral, Child and Adolescent Health, PI, King's College London, UK, on Wed, Nov 18, 2026 at 9am GMT/10am CET, presented in partnership with The Elsevier Foundation\". The Lancet Webinars logo appears in the bottom left corner alongside The Elsevier Foundation logo. Copyright: Elsevier Ltd.

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Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial spkl.io/60187XBc8

Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicent...

Oral deucrictibant provided faster times to symptom relief than placebo and was generally well tolerated. These results support the use of deucrictibant as potentially the first orally administered...

thelancet.com
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By 2050, almost 1 billion people are expected to live with osteoarthritis—a disabling musculoskeletal condition with currently no cure. A new Health Policy outlines a roadmap for global health policy to prioritise, provide care, and prevent osteoarthritis: spkl.io/60107XBrj
Overview of the health policy roadmap. The health policy roadmap is structured around three guiding principles anchoring three strategic priority actions (1\u20133), each underpinned by transformative actions (A\u2013F) and accelerators. See appendix (p 2) for a more detailed figure. Copyright: 2026 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

ALT Overview of the health policy roadmap. The health policy roadmap is structured around three guiding principles anchoring three strategic priority actions (1\u20133), each underpinned by transformative actions (A\u2013F) and accelerators. See appendix (p 2) for a more detailed figure. Copyright: 2026 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

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GLP-1s associated with reduced need for acute psychiatric care for people with schizophrenia and type 2 diabetes, study of US data suggests. Find out more in The Lancet Psychiatry: spkl.io/60197X6Uc
Research in context panel for a paper published in The Lancet Psychiatry, entitled \"GLP-1 receptor agonist initiation and risk of psychiatric hospitalisation and emergency department presentation in adults with schizophrenia and type 2 diabetes in the USA: an observational cohort study using electronic health records data\".

ALT Research in context panel for a paper published in The Lancet Psychiatry, entitled \"GLP-1 receptor agonist initiation and risk of psychiatric hospitalisation and emergency department presentation in adults with schizophrenia and type 2 diabetes in the USA: an observational cohort study using electronic health records data\".

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ICYMI—New antibody treatment reduces number of new abnormal bone lesions by at least 90% in people with ultra-rare genetic disorder, fibrodysplasia ossificans progressiva (FOP), phase 3 study shows. Read now: spkl.io/60127X6rk
Figure showing total number of new heterotopic bone lesions at week 56\nRate ratio versus placebo for the garetosmab 3 mg/kg group: 0\u00B706 (95% CI\n0\u00B700\u20130\u00B773); p=0\u00B7027. Rate ratio versus placebo for the garetosmab 10 mg/kg\ngroup: 0\u00B710 (0\u00B701\u20130\u00B776); p=0\u00B7026. *Rate is defined as the number of new\nheterotopic bone lesions divided by the sample size. Copyright: 2026 Elsevier Ltd. All rights reserved.

ALT Figure showing total number of new heterotopic bone lesions at week 56\nRate ratio versus placebo for the garetosmab 3 mg/kg group: 0\u00B706 (95% CI\n0\u00B700\u20130\u00B773); p=0\u00B7027. Rate ratio versus placebo for the garetosmab 10 mg/kg\ngroup: 0\u00B710 (0\u00B701\u20130\u00B776); p=0\u00B7026. *Rate is defined as the number of new\nheterotopic bone lesions divided by the sample size. Copyright: 2026 Elsevier Ltd. All rights reserved.

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ICYMI—In people with type 2 diabetes at increased cardiovascular risk, the cardiovascular safety of orforglipron was confirmed by demonstrating non-inferiority to insulin glargine for MACE-4. Phase 3 ACHIEVE-4 trial supports orforglipron as potential once-daily, oral treatment option. spkl.io/60137X6Hf
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Replying to @TheLancet @IHME_UW @UNFPA
A Lancet Editorial discusses the key findings from the Commission and calls for a broader approach to protecting health and human survival: tinyurl.com/7u83p96v
https://tinyurl.com/7u83p96v

ALT https://tinyurl.com/7u83p96v

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📈 1 in 8 patients in African hospitals are critically ill — most don't get essential care. Join Tim Baker on 18 Nov to hear how his team's Tanzania programme cut inpatient mortality by 31%. 👉 Register: spkl.io/60127pz32 #GlobalHealth #CriticalCare #EvidencetoImpact
Dark blue graphic with photo of Tim Baker. White text on graphic reads: \"From Evidence to Impact: Winning Case Studies from The Lancet-Elsevier Foundation Awards, join Tim Baker, Associate Professor and Critical Care Physician, and Anaesthesiologist, Muhimbili University of Health and Allied Sciences, and Karolinska Institutet, Tanzania, on Wed, Nov 18, 2026 at 9am GMT/10am CET, presented in partnership with The Elsevier Foundation\". The Lancet Webinars logo appears in the bottom left corner alongside The Elsevier Foundation logo. Copyright: Elsevier Ltd.

ALT Dark blue graphic with photo of Tim Baker. White text on graphic reads: \"From Evidence to Impact: Winning Case Studies from The Lancet-Elsevier Foundation Awards, join Tim Baker, Associate Professor and Critical Care Physician, and Anaesthesiologist, Muhimbili University of Health and Allied Sciences, and Karolinska Institutet, Tanzania, on Wed, Nov 18, 2026 at 9am GMT/10am CET, presented in partnership with The Elsevier Foundation\". The Lancet Webinars logo appears in the bottom left corner alongside The Elsevier Foundation logo. Copyright: Elsevier Ltd.

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Sexual and reproductive health and rights are among the greatest public health and development achievements of our time, helping millions of women gain greater control over their health, education and economic futures. Yet progress cannot be taken for granted. Expanded access to contraception, safe abortion services, and advances in cervical cancer prevention and care are among the landmark gains that have improved health outcomes and strengthened the agency of women and girls worldwide. At a moment of profound global change, we must continue to champion evidence-based policies that protect rights, expand opportunities and advance health for all. In a new paper published in @TheLancet, my colleague Dr @PascaleAllotey and I reflect on why safeguarding and advancing these essential rights remains critical for the health and well-being of women and girls, their families, and their communities. thelancet.com/journals/lanog…
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Can we delay the progression of type 1 diabetes? Join Chantal Mathieu at The #LancetSummit (Nov 30-Dec 2, Sitges) to explore the latest advances in #T1D. Register by Oct 31, 2026 using voucher code TLDC100 to save €100: spkl.io/60137VupS
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New Lancet Series: the way digital technologies are built & governed creates real health risks worldwide. A review of 9 million under-25s across 121 studies links digital media use to mental health & sleep problems plus reduced physical activity. Authors call for urgent, coordinated action. ➡️ spkl.io/60107nbyg
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Hashimoto's thyroiditis is the most frequent autoimmune thyroid disease & the leading cause of hypothyroidism. In @TheLancetEndo, a Review summarises developments over the past two decades and considers emerging approaches to precision medicine: spkl.io/60117nbZx
Transverse sonogram of the thyroid gland showing diffuse hypoechogenicity and heterogeneous echotexture. Electronic calipers (+) mark the anteroposterior (1) and transverse (2) diameters of the right lobe. Copyright: 2026 Elsevier Ltd. All rights are reserved.

ALT Transverse sonogram of the thyroid gland showing diffuse hypoechogenicity and heterogeneous echotexture. Electronic calipers (+) mark the anteroposterior (1) and transverse (2) diameters of the right lobe. Copyright: 2026 Elsevier Ltd. All rights are reserved.

Longitudinal sonogram of the right thyroid lobe showing a small, well-defined, isoechoic or hyperechoic White-Knight nodule (yellow arrows) within diffusely hypoechoic, heterogeneous thyroid parenchyma; electronic calipers (+) mark the longitudinal diameter of the nodule. The nodule shows no calcifications. White-Knight nodules are associated with Hashimoto's thyroiditis and typically have benign sonographic features. Copyright: 2026 Elsevier Ltd. All rights are reserved.

ALT Longitudinal sonogram of the right thyroid lobe showing a small, well-defined, isoechoic or hyperechoic White-Knight nodule (yellow arrows) within diffusely hypoechoic, heterogeneous thyroid parenchyma; electronic calipers (+) mark the longitudinal diameter of the nodule. The nodule shows no calcifications. White-Knight nodules are associated with Hashimoto's thyroiditis and typically have benign sonographic features. Copyright: 2026 Elsevier Ltd. All rights are reserved.

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TRIUMPH-2 findings suggest that retatrutide might advance the treatment of people with obesity and type 2 diabetes, showing bodyweight reduction alongside improvements in glycaemic control and cardiometabolic risk factors. Read more: spkl.io/60147VfXi #EASD2026
Promotional card for a paper published in The Lancet entitled \"Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial\". Card features the title and summary sections of the paper and has a banner at the top reading \"62nd Annual meeting of the European Association for the Study of Diabetes (EASD)\".

ALT Promotional card for a paper published in The Lancet entitled \"Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial\". Card features the title and summary sections of the paper and has a banner at the top reading \"62nd Annual meeting of the European Association for the Study of Diabetes (EASD)\".

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What does it take to turn good research into lasting change? Ask the teams who've actually done it. Join Maha Rhannam as she co-hosts our webinar with the inaugural Evidence to Impact Award winners. 👉 Register: spkl.io/60127pzzy #GlobalHealth #EvidencetoImpact
Dark blue graphic with photo of Maha Rhannam. White text on graphic reads: \"From Evidence to Impact: Winning Case Studies from The Lancet-Elsevier Foundation Awards, join Maha Rhannam, Elsevier Foundation Partnerships Manager, Elsevier, Netherlands, on Wed, Nov 18, 2026 at 9am GMT/10am CET, presented in partnership with The Elsevier Foundation\". The Lancet Webinars logo appears in the bottom left corner alongside The Elsevier Foundation logo. Copyright: Elsevier Ltd.

ALT Dark blue graphic with photo of Maha Rhannam. White text on graphic reads: \"From Evidence to Impact: Winning Case Studies from The Lancet-Elsevier Foundation Awards, join Maha Rhannam, Elsevier Foundation Partnerships Manager, Elsevier, Netherlands, on Wed, Nov 18, 2026 at 9am GMT/10am CET, presented in partnership with The Elsevier Foundation\". The Lancet Webinars logo appears in the bottom left corner alongside The Elsevier Foundation logo. Copyright: Elsevier Ltd.

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The Lancet Commission on 21st Century Global Threats to Health stands as an independent voice bringing together diverse experts to examine the broad set of threats facing the world over the rest of the century. Read the report published today: ms.spr.ly/6010aq8MY
Promotional graphic split with a teal banner across the top and a cream-colored background below, featuring thin teal and cream stripes along the right edge. On the right, a mockup of a Lancet journal cover dated October 2026 reads \"THE LANCET\" at the top, followed by the title \"The Lancet Commission on 21st century global threats to health\" in blue text. Below the title, a circular icon wheel divided into 17 colored wedges surrounds a globe graphic, each wedge containing a small white icon representing a different threat (such as a cigarette, factory, skull, radiation symbol, heart, and wine glass); a blue bar at the bottom of the cover reads \"An Executive Summary for The Lancet's Commission.\" On the left, large bold black text reads \"17 catastrophic threats. One shared framework for action.\" In the bottom left corner, \"THE LANCET\" wordmark appears alongside the circular green-and-teal IHME logo and the word \"IHME.\"

ALT Promotional graphic split with a teal banner across the top and a cream-colored background below, featuring thin teal and cream stripes along the right edge. On the right, a mockup of a Lancet journal cover dated October 2026 reads \"THE LANCET\" at the top, followed by the title \"The Lancet Commission on 21st century global threats to health\" in blue text. Below the title, a circular icon wheel divided into 17 colored wedges surrounds a globe graphic, each wedge containing a small white icon representing a different threat (such as a cigarette, factory, skull, radiation symbol, heart, and wine glass); a blue bar at the bottom of the cover reads \"An Executive Summary for The Lancet's Commission.\" On the left, large bold black text reads \"17 catastrophic threats. One shared framework for action.\" In the bottom left corner, \"THE LANCET\" wordmark appears alongside the circular green-and-teal IHME logo and the word \"IHME.\"

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What will shape the health of the next generation? A new Lancet Commission outlines 17 interlinked catastrophic threats to health and human survival between 2025 and 2100: spkl.io/60157nJvz #21stCenturyThreatsToHealth @IHME_UW @UNFPA
Promotional card for The Lancet Commission on 21st century global threats to health. Text on card reads '17 catastrophic threats. One shared framework for action.' There are also icons representing each of the 17 threats, e.g. a thermometer for Climate Change and a brain for Poor Mental Health.

ALT Promotional card for The Lancet Commission on 21st century global threats to health. Text on card reads '17 catastrophic threats. One shared framework for action.' There are also icons representing each of the 17 threats, e.g. a thermometer for Climate Change and a brain for Poor Mental Health.

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The authors provide three key recommendations: 👉 Build threat-ready, equitable health systems 👉 Back breakthrough innovations 👉 Track threats Find out more: spkl.io/60157nJvz
Promotional card for The Lancet Commission on 21st century global threats to health representing the three recommendations from the Commission. Computer-generated images of a hospital, light bulb, and a target sight have the following text below them. 1. Build threat-ready, equitable health systems that respond to a wide range of health threats, not just pandemics. 2. Back breakthrough innovation including new vaccines, antibiotics, obesity treatments, and climate technologies. 3. Track threats so that evidence keeps pace with emerging and changing risks.

ALT Promotional card for The Lancet Commission on 21st century global threats to health representing the three recommendations from the Commission. Computer-generated images of a hospital, light bulb, and a target sight have the following text below them. 1. Build threat-ready, equitable health systems that respond to a wide range of health threats, not just pandemics. 2. Back breakthrough innovation including new vaccines, antibiotics, obesity treatments, and climate technologies. 3. Track threats so that evidence keeps pace with emerging and changing risks.

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“The Commission expands, quantifies, and legitimises a far broader range of interconnected dangers to humanity.” Read a linked Editorial - 'Rethinking threats to human survival' tinyurl.com/ynhjhfrt
The Lancet's Editorial entitled 'Rethinking threats to human survival'.

ALT The Lancet's Editorial entitled 'Rethinking threats to human survival'.

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