🚨 Major update of autism genetics from Talkowski and Daly Integrating information from 62,429 autism cases across study designs, ascertainment criteria, and genetic variant classes: identify 253 autosomal genes where damaging variants contribute to autism with high statistical confidence. Subsets of the 253 genes are more associated with autism with or without DD/ID, and meta-analysis of cases ascertained for autism and those ascertained for developmental disorders identified 497 genes (including 150 that are not statistically significant in either cohort alone). "These results support a genetic architecture of autism that is partially distinct and partially shared with other developmental outcomes."