Diving into hemostasis was a personal flashblack to my own thesis studies on #complement proteins. doi.org/10.1101/2024.11.11.6… Our exploration started w/ observation that prothrombin (factor II) modulates T cell function, suggesting that factor II may regulate immune exhaustion

Excited to finally share this intriguing discovery that has mechanistically perplexed our group for years. Led by Alex (@CincyMSTP) & @RachLCan22 of @CincyImmunology w/ #PalumboLab, we find that prothrombin prevent fatal T cell-dependent hemolytic anemia during virus infection