Assistant Professor, Human Genetics @EmoryMedicine | PhD @UChiChemistry | HHWF Postdoc Fellow @broadinstitute @ChemistryMIT | Spatial -Omics | RNA biology
Atlanta, GA
Joined March 2021
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Thrilled to see our work finally online! We utilized in situ spatial transcriptomic method STARmap PLUS to map 1.09 million cells in the adult mouse central nervous system at molecular resolution and identified previously unknown tissue architectures.
nature.com/articles/s41586-0…
Hailing Shi retweeted
Chapter 2 of branched RNA: chemically modified branched cap for multi-capped mRNA and capped circular RNA (QRNA)--the cellular translation machinery is surprisingly tolerant of unnatural structures! Beyond enhanced performance, the mechanism is intriguing: rdcu.be/dUQKX
Synthesizing RNA can be as fun as LEGO puzzles! This work is co-led by my incredible colleagues @LDangliang and @AbhiAditham . Huge thanks to my supervisor @WangXiaoLab for such amazing ideas. We are also grateful for the editor, reviewers, and all collaborators along the way.
Hailing Shi retweeted
Spatial omics technology is transforming our understanding of in situ RNA biology. We are grateful for the opportunity to publish this review in @MolecularCell. We hope this will be a useful resource for the community. @HailingShi @nemo08061 @WangXiaoLab
Hailing Shi retweeted
Excited to share Deep-STARmap and Deep-RIBOmap! We enabled spatial transcriptomic and translatomic mapping of >1K genes in 200 µm thick tissue and neuron morphology co-profiling.
Thanks @WangXiaoLab for unwavering support; Jennifer for human skin study! biorxiv.org/content/10.1101/…
Hailing Shi retweeted
Congratulations to Broad core member @WangXiaoLab on earning tenure with @ChemistryMIT!
Congratulations to Xiao Wang (@WangXiaoLab), the Cabot Assistant Professor of Chemistry and a Core Member of @broadinstitute , who has been promoted to Associate Professor With Tenure, effective July 1, 2024.
chemistry.mit.edu/chemistry-…
Hailing Shi retweeted
Congratulations to Xiao Wang (@WangXiaoLab), the Cabot Assistant Professor of Chemistry and a Core Member of @broadinstitute , who has been promoted to Associate Professor With Tenure, effective July 1, 2024.
chemistry.mit.edu/chemistry-…
We aimed to build a large-scale single-cell resolved spatial atlas of the mouse brain. We utilized STARmap PLUS, an image-based targeted spatial transcriptomics method, and ClusterMap, an unsupervised framework for cell and tissue segmentation.
This work is built on previous scRNA-seq atlas from @slinnarsson @s_mccarroll @macosko and @AllenInstitute. We were also inspired by the molecular atlas concept from @meletislab.
doi.org/10.1016/j.cell.2018.…
doi.org/10.1016/j.cell.2018.…
doi.org/10.1016/j.cell.2021.…
science.org/doi/10.1126/scia…
This atlas adds to the community's ongoing efforts to map cell diversity in the whole mouse brain. Exciting results are on the horizon!
biorxiv.org/content/10.1101/…
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