@HanSun_lab

We work on drug-like molecules and characterize their interactions with proteins. #NMR #MDSimulation #cheminformatics #bioinformatics @LeibnizFMP and @TUBerlin

 Berlin, Deutschland
leibniz-fmp.de/sun
Joined August 2015
  • Tweets1.4K
  • Following232
  • Followers277
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Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data pubs.acs.org/doi/10.1021/acs… @ChriSchmied @HanSun_lab @LeibnizFMP #JCIM Vol65 Issue2 #MachineLearning #DeepLearning

Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data

Abstract. Morphological profiling has recently demonstrated remarkable potential for identifying the biological activities of small molecules. Alongside th

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The @cecamEvents Flagship Workshop is coming to Madison, July 14-16, 2025! Hosted at @datascience_uw (thanks!), organized by @drGregBowman, @BettinaGKeller, and me (CECAM-US-CENTRAL). We have slots for contributed talks - apply here (deadline: June 11): cecam.org/workshop-details/b…
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📥#Job opening for a #PhD student in our group @mpi_nat in Göttingen 🇩🇪 in connection to #RTG2756 #CYTAC Job advert 🔗mpinat.mpg.de/4793823/28-24?… 🔗uni-goettingen.de/rtg2756 #mircotubules #Applications welcome!
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HanSun_lab retweeted
Spektrum@spektrum8 Oct 2024
In dieser Episode sprechen wir über Ionenkanäle, ihre Rolle im Gehirn und wie der AMPA-Rezeptor elektrische Signale steuert. 🎙️ spektrum.de/podcast/wirkstof…

Wirkstoffradio: Der AMPA-Rezeptor

In dieser Episode sprechen wir über Ionenkanäle, ihre Rolle im Gehirn und wie der AMPA-Rezeptor elektrische Signale steuert

spektrum.de
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HanSun_lab retweeted
Spektrum@spektrum3 Sep 2024
In dieser Episode erklärt Dr. Sanja Bauer Mikulovic Bernd Rupp, wie die Neurobiologie der Kognition und der Emotionen funktionieren. 🎙️ spektrum.de/podcast/wirkstof…

Wirkstoffradio: Die Neurobiologie der Emotion und Kognition

In dieser Episode erklärt Dr. Sanja Bauer Mikulovic Bernd Rupp, wie die Neurobiologie der Kognition und der Emotionen funktionieren und wie der Körper au…

spektrum.de
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The new work from Lange lab @NatureComms shows how we can use SMA/DIBMA to not only see associated lipids, but can estimate their binding & study activity of intramembrane proteases in these systems through collisional mixing! nature.com/articles/s41467-0…

Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease...

Nature Communications - Collisional mixing of lipids in SMA or DIBMALPs has been shown recently. Here, authors show proteins in these nanoparticles also undergo mixing, allowing for study of...

nature.com
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New insights @HanSun_lab in collaboration with the Baukrowitz lab (University of Kiel), on phosphorylation of TREK channels could offer therapeutic potential for ischemia, epilepsy & depression, published @NatureComms More: leibniz-fmp.de/newsroom/news… Illustration: @BarthvanRossum
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Happy to start working with new 1,2 GHz NMR spectrometer - perfect for precise analysis of complex biological systems like #proteinstructures ! Peter Schmieder, @HanSun_lab , Adam Lange, @MillesSigrid , Hartmut Oschkinat Read more 👇 leibniz-fmp.de/newsroom/news…
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The very best congratulations Frauke! That's great news!
Max-Planck-Institut für Polymerforschung@mpi_polymer25 Jun 2024
Prof. Frauke Gräter @graeter_mbm joins @mpi_polymer as new Director starting July 1, 2024! 🎉 Her groundbreaking work in molecular biomechanics, simulations and machine learning promises a bright future for soft matter research. 🌟 #Research #Innovation #AI (Photo: HITS)
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Replying to @DriessLab
Here's our corresponding Research Highlight article: How stable are the electrodes we design at #UniSysCat under real operating conditions? Can they compete with the ones in use for #hydrogen production? #catalysis #chemistry #sciencenews @AdvSciNews unisyscat.de/news-events/new…
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Morgen ist es schon so weit: die lange Nacht der Wissenschaften 2024 erwartet euch. Und wir veranstalten ein exzellentes Science #Pubquiz an der @TUBerlin zusammen mit den 7 Exzellenzclustern aus #Berlin 👇 Kommt vorbei und rätselt mit 🧐 @LNDWBerlin
UniSysCat - Cluster of Excellence@UniSysCat11 Jun 2024
💡Alle #Quiz-Fans aufgepasst! Die Berliner #Exzellenzcluster laden zum #Science #Pubquiz ein: Im Rahmen der @LNDWBerlin wird in zwei Runden um 19 und 20:30 Uhr an der @TUBerlin gerätselt bis die Köpfe qualmen 🤯 Anmeldund vor Ort - kommt einfach vorbei, wir freuen uns auf euch!
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🔬👨‍🔬👩🏼‍🔬🧪🥼Auf dem Campus Berlin-Buch erwartet Groß und Klein ein umfangreiches Programm mit Laborführungen, Mitmachexperimenten, Kinderprogramm mit Forschungsdiplom sowie Rundgänge zur Wissenschaftsgeschichte und Campusentwicklung. @MDC_Berlin @glaeserneslabor @SilenceTheraPlc – at Berlin, Germany
FMP Berlin (now on Bluesky)@LeibnizFMP20 Jun 2024
Auf dem @campusbuch begrüßen wir euch bereits ab 16 Uhr zur Langen Nacht der Wissenschaften. 👉 Programm langenachtderwissenschaften.… #lndw24
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👉3rd German workshop on structural predictions of membrane proteins: From ion channels to G protein-coupled receptors February 26–28, 2024 Antonella Di Pizio (from @LeibnizLSB & TUM) is one of the organizers. @dipizio_lab fz-juelich.de/en/ias/ias-5/c…
Screenshot von der Website: Jülich Forschungszentrum, als Symbolbild gedacht.

ALT Screenshot von der Website: Jülich Forschungszentrum, als Symbolbild gedacht.

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In order to ensure Europe’s competitive edge in global science and technology, the ERC Scientific Council calls for a doubling of the budget of the next EU research framework programme (FP10) and maintaining the ERC’s independence. Read the statement: erc.europa.eu/news-events/ne…
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"I’m not a neuroscientist, remember. I’m a basic scientist, but my work has enabled people to develop these tools. This is why basic science is important: it creates the knowledge for others to develop as they see fit." cen.acs.org/people/profiles/… @cenmagより

Peter Hegemann, a scientist trying to illuminate the brain

The photobiologist explains how careful manipulation of light has revealed a path to better understand how the brain works

cen.acs.org
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Allosteric Activation in Potassium Channels: A drug-like molecule (yellow) limits C-terminal domain movement in TREK K+ channels, keeping them active. Findings from molecular dynamics simulations & electrophysiology. Picture of the month by Berke Türkaydin @HanSun_Lab Congrats!👏
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Exciting news by Lange Lab & @HanSun_Lab on #RhomboidProteases. Our study @ScienceAdvances sheds light on their gate dynamics, helping understand roles in diseases like cancer & Parkinson's & sees potential in them as therapeutic targets. #nmr 👉leibniz-fmp.de/newsroom/news…
“Closing the gate: Introduction of an M2M cross-link blocks the entrance of substrates to the active site (white, blue, and red) of the rhomboid protease GlpG. The gate and other transmembrane helices of GlpG are shown in light and dark blue, respectively, and the lipid environment in black (Barth van Rossum, FMP).”Visualization by Barth van Rossum

ALT “Closing the gate: Introduction of an M2M cross-link blocks the entrance of substrates to the active site (white, blue, and red) of the rhomboid protease GlpG. The gate and other transmembrane helices of GlpG are shown in light and dark blue, respectively, and the lipid environment in black (Barth van Rossum, FMP).”Visualization by Barth van Rossum

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HanSun_lab retweeted
Spektrum@spektrum26 Jun 2023
… 🎙️ spektrum.de/podcast/neue-weg…

Die unentdeckte Vielfalt der Aktinomyceten: Neue Wege zur Synthese von Wirkstoffen - Interview mit...

In dieser Episode erklärt Prof. Dr. Yvonne Mast, was die Aktivierung stiller Synthesegencluster bei Aktinomyceten mit neuen Wirkstoffen zu tun hat.

spektrum.de
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Neue Folge! WSR067 Opioid-Analgetika: Von Morphin, Oxycodon und Fentanyl bis Ziconotid und Flupirtin mit Hans-Dieter Höltje und Bernd Rupp (@rupi42ai). wirkstoffradio.de/2023/07/16… #Schmerzmittel #Morphin #Methadon #Opioide #Paracetamol #Analgetika #Conusschnecken #Oxycodon #Fentanyl

WSR067 Opioid-Analgetika: Von Morphin, Oxycodon und Fentanyl bis Ziconotid und Flupirtin

In dieser Episode sprechen Hans-Dieter Höltje und Bernd Rupp über Opioid-Analgetika und andere Wirkmechanismen zur Bekämpfung starker Schmerzen. Sie behandeln sowohl klassische Wirkstoffe wie Morphin...

wirkstoffradio.de
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HanSun_lab retweeted
SynPepBio@synpepbio7 Jul 2023
This week the 4th retreat of our grad school took place - what a blast! Amazing lectures, awards, re-connecting over balloon animals and of course great company! Special thanks to Christina Schroeder, @David_Lab_MSK, @HanSun_lab and Thomas Vorherr and our organizers!
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