@HanSun_lab

We work on drug-like molecules and characterize their interactions with proteins. #NMR #MDSimulation #cheminformatics #bioinformatics @LeibnizFMP and @TUBerlin

 Berlin, Deutschland
leibniz-fmp.de/sun
Joined August 2015
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Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data pubs.acs.org/doi/10.1021/acs… @ChriSchmied @HanSun_lab @LeibnizFMP #JCIM Vol65 Issue2 #MachineLearning #DeepLearning

Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data

Abstract. Morphological profiling has recently demonstrated remarkable potential for identifying the biological activities of small molecules. Alongside th

pubs.acs.org
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Replying to @LesotPhilippe
Thanks Phil!
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The first paper from our ⁦@synpepbio⁩ graduate student! We assessed the performance of a high number of DFT functionals in predicting chemical shielding tensors and evaluated their impact on structure elucidation using anisotropic NMR data. pubs.acs.org/doi/10.1021/acs…

Benchmark of Density Functional Theory in the Prediction of 13C Chemical Shielding Anisotropies for...

Abstract. Density functional theory (DFT) calculations have emerged as a powerful theoretical toolbox for interpreting and analyzing the experimental nucle

pubs.acs.org
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We are excited to present our DL model for bioactivity prediction using Cell Painting data. Please check out our new JCIM publication for details
Machine Learning in Chemistry@ML_Chem7 Jan 2025
Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data #machinelearning #compchem pubs.acs.org/doi/abs/10.1021…

Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data

Abstract. Morphological profiling has recently demonstrated remarkable potential for identifying the biological activities of small molecules. Alongside th

pubs.acs.org
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The @cecamEvents Flagship Workshop is coming to Madison, July 14-16, 2025! Hosted at @datascience_uw (thanks!), organized by @drGregBowman, @BettinaGKeller, and me (CECAM-US-CENTRAL). We have slots for contributed talks - apply here (deadline: June 11): cecam.org/workshop-details/b…
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Very happy and proud to see our collaborative work with Jörg Standfuss, Peter Hegemann and Igor Schapiro labs is published now in JACS: Structural Insights Into the Opening Mechanism of C1C2 Channelrhodopsin pubs.acs.org/doi/10.1021/jac…

Structural Insights Into the Opening Mechanism of C1C2 Channelrhodopsin

Abstract. Channelrhodopsins, light-gated cation channels, enable precise control of neural cell depolarization or hyperpolarization with light in the field

pubs.acs.org
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We are very grateful for this exciting opportunity provided by Leibniz Cooperative Excellence. Looking forward to new collaborations through this framework. Within this funding opportunity, we have one job opening for a PhD student or Postdoc: leibniz-fmp.softgarden.io/jo…
FMP Berlin (now on Bluesky)@LeibnizFMP17 Dec 2024
Exciting news! @LeibnizFMP, @kieluni & @LeibnizLIV are starting new project, supported through "Leibniz CooperativeExcellence" program. Goal: Unravel mechanisms of K2P potassium channels – with potential new therapeutic approaches. leibniz-fmp.de/newsroom/news… #LeibnizWGL @HanSun_lab
Structural model of a TREK-2 K2P channel (blue and light pink. The dark pink spheres represent potassium ions transported through the channel.

ALT Structural model of a TREK-2 K2P channel (blue and light pink. The dark pink spheres represent potassium ions transported through the channel.

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Replying to @VolkerHaucke
Congratulations!
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Congratulations! Very well deserved
Christopher Schmied@ChriSchmied18 Nov 2024
I am honored to receive the 2024 Early Career @Einstein_Berlin Award together with @helenajambor for our project "PixelQuality: Best Practices for Publishing Images": award.einsteinfoundation.de/… Thank you to our amazing team @QuarepLimi and my hosts @EuOpenscreen and @LeibnizFMP
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We have an open position for studying two-pore domain potassium channels using MD simulations and single-particle Cryo-EM. Please help us spread the word: leibniz-fmp.softgarden.io/jo…
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📥#Job opening for a #PhD student in our group @mpi_nat in Göttingen 🇩🇪 in connection to #RTG2756 #CYTAC Job advert 🔗mpinat.mpg.de/4793823/28-24?… 🔗uni-goettingen.de/rtg2756 #mircotubules #Applications welcome!
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HanSun_lab retweeted
Spektrum@spektrum8 Oct 2024
In dieser Episode sprechen wir über Ionenkanäle, ihre Rolle im Gehirn und wie der AMPA-Rezeptor elektrische Signale steuert. 🎙️ spektrum.de/podcast/wirkstof…

Wirkstoffradio: Der AMPA-Rezeptor

In dieser Episode sprechen wir über Ionenkanäle, ihre Rolle im Gehirn und wie der AMPA-Rezeptor elektrische Signale steuert

spektrum.de
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HanSun_lab retweeted
Spektrum@spektrum3 Sep 2024
In dieser Episode erklärt Dr. Sanja Bauer Mikulovic Bernd Rupp, wie die Neurobiologie der Kognition und der Emotionen funktionieren. 🎙️ spektrum.de/podcast/wirkstof…

Wirkstoffradio: Die Neurobiologie der Emotion und Kognition

In dieser Episode erklärt Dr. Sanja Bauer Mikulovic Bernd Rupp, wie die Neurobiologie der Kognition und der Emotionen funktionieren und wie der Körper au…

spektrum.de
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The new work from Lange lab @NatureComms shows how we can use SMA/DIBMA to not only see associated lipids, but can estimate their binding & study activity of intramembrane proteases in these systems through collisional mixing! nature.com/articles/s41467-0…

Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease...

Nature Communications - Collisional mixing of lipids in SMA or DIBMALPs has been shown recently. Here, authors show proteins in these nanoparticles also undergo mixing, allowing for study of...

nature.com
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A significant milestone for our Cell Painting project. Well done, Christopher! This is the result of a collaborative effort over many years by four imaging sites at EU-OPENSCREEN. @EuOpenscreen @LeibnizFMP
Christopher Schmied@ChriSchmied28 Aug 2024
Today we release the first set of #opensource Cell Painting Data generated in the @EuOpenscreen network by @LeibnizFMP, @IMTM_Olomouc, @MEDINADiscovery, @UniversidadeUSC and @imgprague. Bioactive compounds over Hep G2 and U2-OS and 4 sites. Preprint: doi.org/10.1101/2024.08.27.6…
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Replying to @philbiggin
Congrats!🎉
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Replying to @philbiggin
Very cool!
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New insights @HanSun_lab in collaboration with the Baukrowitz lab (University of Kiel), on phosphorylation of TREK channels could offer therapeutic potential for ischemia, epilepsy & depression, published @NatureComms More: leibniz-fmp.de/newsroom/news… Illustration: @BarthvanRossum
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Replying to @wojciechkopec3 @PNASNexus
Congratulations! 🎉🎉🎉
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Replying to @LesotPhilippe @MagnResonChem @RobertoRGil @PatGiraudeau @ICMMO_UMR8182 @CNRSchimie
Phil, it was really a great honor for me to work together with you on this special issue.
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