Our lab works on understanding genome stability and its role in cancer, using model systems (yeast, worms, & cancer cells). Find us in Michael Smith Labs @ UBC.
Vancouver, British Columbia
Joined October 2015
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Our latest work is now out in DNA Repair. Synthetic cytotoxicity profiling of cohesin mutants highlights recombi... sciencedirect.com/science/ar… @ubcmsl
Our collaboration with @StirlingLab now out at PNAS. Deep structure–function analysis of the endonuclease Mus81 with dominant mutational scanning | PNAS pnas.org/doi/10.1073/pnas.25…
Excited to see this interesting story get published. @ubcmsl Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science science.org/doi/10.1126/scie…
New SL paper from the Hieter and Stirling labs @stirlinglab . Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency pubmed.ncbi.nlm.nih.gov/3847…
Hieter Lab retweeted
.@ubcpharmacy professor Dr. Corey Nislow & Dr. @philhieter of MSL's @HieterLab discuss yeast research from NASA’s #Artemis 1 lunar mission.
UBC scientist’s ‘mutant yeast’ from space could help future astronauts, cancer patients | Globalnews.ca globalnews.ca/news/9403445/s…
Hieter Lab retweeted
RAD18 opposes transcription-associated genome instability through FANCD2 recruitment dlvr.it/Sf4W0l
Hieter Lab retweeted
ALL-TIME RECORD | We are proud to award 90 new research grants valued at $10.8 million as part of our annual competition. The grants are awarded to some of the most promising cancer research projects in Canada. 🎉🔬
👉 bit.ly/3xUiHfe
#CancerResearchSociety
Hieter Lab retweeted
#GENETICS and #G3journal are pleased to announce a Call for Papers on Genetic Models of Rare Diseases. This new series is led by Brenda Andrews, Hugo Bellen, @dougfowler42, and @HieterLab; submissions for the launch issue are due November 14! #rarediseases bit.ly/3dtembD
ALT Computer-graphic of a colorful neuron advertising a Call for Papers on Genetic Models of Rare Diseases from GENETICS and G3 journals. Submissions due November 14, 2022.
Hieter Lab retweeted
🎉 Congratulations to everyone who received awards in August! ☀️
Dr. Philip Hieter (@HieterLab) received a @CIHR_IRSC grant to expand the impact and reach of the Canadian ‘#RareDiseases: Models and Mechanisms’ Network.
See more award winners:
scienceinvancouver.com/2022/…
The Hieter Lab is at #yeast22. Anthony Oppedisano is presenting "Mutational Scanning to find Synthetic Lethal interactions with the repair endonuclease Mus81" on Friday evening. Poster 177B.
Hieter Lab retweeted
I’m very excited to share that my PhD work is now published @eLife! We used a combination of genetics, cell biology and biochemistry to identify a new endosomal complex in yeast, which we named VINE 🌿 Early access here: elifesciences.org/articles/7…. (1/n).
Hieter Lab retweeted
Congratulations to Dr. Leanne Amitzi on her graduation today! 🎓 Dr. Amitzi, of the @HieterLab, has successfully earned her Doctor of Philosophy (#PhD) in Medical #Genetics ! 🎉🧬
Hieter Lab retweeted
Join us today for our seminar with Dr. Maitreya Dunham (@DunhamLab) from @uwgenome on "High throughput human genetics in yeast".
April 13th, 3-4pm, PST
Host: Dr. Phil Hieter (@HieterLab)
Event details & zoom registration:
msl.ubc.ca/event/msl-seminar…
Hieter Lab retweeted
Drs. Peter Stirling (@pcstirling), David Huntsman, & Philip Hieter (@HieterLab) received an @OvarianCanada/@SRC_CRS grant to develop drugs that will convert proteins that normally repair DNA into toxic agents that selectively kill #OvarianCancer cells. 🧬
bit.ly/3rrb6Cw
New from us in collaboration with the Moffat Lab at
@DonnellyCentre. Great work by Melanie Bailey using CRISPR screens to find STAG2 dependencies in 3 different cell lines.
@HieterLab uses CRISPR-Cas9 screening to explore the context-dependency of genetic interactions of the cancer-mutated cohesin gene STAG2 in three different cellular backgrounds @HieterLab @ubcmsl
life-science-alliance.org/co…
Hieter Lab retweeted
Great review of disease modelling and drug discovery in worms! Really highlights how versatile worms are.
journals.biologists.com/dmm/…
We got the band back together for this Gpn2 RNA polymerase biogenesis story. Collaboration with @StirlingLab
tandfonline.com/doi/abs/10.1…
Hieter Lab retweeted
#CMHFLaureate @mmarra0630 head of the Personalized Oncogenomics project @BCCancer, using information derived from thousands of individual #cancer genomes & transcriptomes to identify promising therapeutic targets in individual patients bit.ly/3gNglXZ
Setting molecular traps in yeast for identification of anticancer drug targets pnas.org/content/118/18/e210…
An insightful commentary by @drgrantwbrown and Brenda Andrews of the @DonnellyCentre referencing our recent PNAS manuscript.
New from the Hieter lab at @ubcmsl : Modeling DNA trapping of anticancer therapeutic targets using missense mutations identifies dominant synthetic lethal interactions pnas.org/content/118/14/e210…
Great work by Akil Hamza and Leanne Amitzi who co-lead the project and characterized Fen1 and Chl1 respectively. Thanks to @CCSResearch and @CIHR_IRSC for the funding that made the research possible.