@HowittLab

We study the microbiome and its effect on intestinal immunity

 Stanford University
howittlab.com
Joined March 2020
  • Tweets72
  • Following130
  • Followers406
6Media
Howitt Lab retweeted
Long Lab@longlabstanfordOct 22
Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung! cell.com/cell/fulltext/S0092…

MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss

The orphan transporter MCT6 is the route by which the meal- and exercise-associated metabolite Lac-Phe exits intestinal cells and enters the blood. Mice lacking gut MCT6 cannot maintain normal...

cell.com
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Not the first and likely not the last review on tuft cells. But for sure the most recent one, published in @NatRevGastroHep: Kalle and @XiaogangFeng did a great job summarizing recent findings related to tuft cells nature.com/articles/s41575-0… full-text access: rdcu.be/dVaOi
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Howitt Lab retweeted
Immunity@ImmunityCP22 Jul 2024
Online now: Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation dlvr.it/T9wX6X

Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation

Epigenomic features steering CD8+ T cell heterogeneity across tissues has not yet been extensively explored. By profiling chromatin accessibility changes and gene expression in T cells derived from...

cell.com
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Please join us in welcoming our newest faculty member to the University of Chicago Department of Microbiology, Dr. Elias Roth Gerrick @GerrickElias, who will join as Assistant Professor effective September 1, 2024. (1/3)
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Howitt Lab retweeted
Immunity@ImmunityCP13 May 2024
Online now: Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity dlvr.it/T6qpgG

Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity

Intestinal tuft cells are known as sentinels capable of initiating type 2 immune responses upon parasite infections. Ndjim et al. now report a direct effector function for intestinal tuft cells...

cell.com
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Howitt Lab retweeted
Craig Wilen@WilenLab22 Mar 2024
Very excited to share our paper led by @madisonstrine Intestinal tuft cell immune privilege enables norovirus persistence | Science Immunology science.org/doi/10.1126/scii… 1/n

Intestinal tuft cell immune privilege enables norovirus persistence

Colonic tuft cells can intrinsically resist cytotoxic CD8+ T cells, enabling chronic norovirus infection.

science.org
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Howitt Lab retweeted
DrSouZ@Soumees21 Mar 2024
New preprint from the Bhatt lab! Congratulations @DanicaSchmidtk1 and Angela Hickey!!! 🎊
bioRxiv Microbiology@biorxiv_micrbio21 Mar 2024
Analysis and culturing of the prototypic crAssphage reveals a phage-plasmid lifestyle biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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💥Tenure-Track Faculty Job Alert!💥 Monell has an OPEN SEARCH for MULTIPLE positions (all levels) If you study feeding behavior, metabolism, nutrition, olfaction, taste, chemesthesis, stem cells, or other topic in chemosensory biology, apply! 1/ apply.interfolio.com/79129
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Announcing the 2023 Stanford Immunology Preview event! If you’re interested in applying to our PhD program, you’re invited to this virtual event. You’ll hear from our amazing faculty and students about what makes our scientific community so vibrant. bit.ly/stanfordimmpreview23
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So grateful to the organizers for making this happen! Whatever your interest in tuft cells, come join us!
Christoph Schneider@ChSchneider_PhD1 Mar 2023
Thrilled to announce the first-ever Tuft Cell Meeting: Aug 28-30, 2023 in Germany. With top speakers, it promises to be a fantastic event. uni-giessen.de/de/fbz/fb11/i… for more information. Don't forget to spread the word! If you have cool work on tuft cells, submit your abstract asap
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In fact, you can see Stanley Falkow’s wonderfully presented and timeless two-part introductory lecture on host-pathogen interactions in this archival footage on YouTube: youtu.be/0RZkgWnLXuI No one has ever explained it more masterfully and I recommend it most highly.
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Our latest Emerging Leader in Mucosal Immunology is Jakob von Moltke @jakob_moltke #EmergingLeadersMI! Read his review on initiation of type 2 immunity at barrier surfaces mucosalimmunology.org/articl…
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1/ I'm fortunate to mentor two awesome PhD students who received @NIH F31 awards. These pay about 26K in salary. In NYC, PhD students earn around 46K, leaving a 20K gap. It turns out that I cannot use R01/R21 funding to pay for this gap and have to rely on discretionary funds.
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1/7 Excited to share @nadjsombati’s opus using genetic mapping to uncover differential isoform usage of Pou2af2, and its role in tuft cell differentiation and type 2 immunity in the SI. Critical contributions from @bendesky @natalieniepoth @baldridgelab biorxiv.org/content/10.1101/…

Genetic mapping reveals Pou2af2-dependent tuning of tuft cell differentiation and intestinal type 2...

Chemosensory epithelial tuft cells contribute to innate immunity at barrier surfaces, but their differentiation from epithelial progenitors is not well understood. Here we exploited differences...

biorxiv.org
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Howitt Lab retweeted
Craig Wilen@WilenLab22 Sep 2022
For anyone interested in studying #tuftcells (which should be everyone!), we deposited our Pou2f3 KO mice. They are available on the @jacksonlab live repository for a short time and then get frozen and expensive so order soon jax.org/strain/037040
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BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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Join us virtually or in person for this celebration of Sparky Lok’s career, his pioneering contributions to molecular helminthology, and to the scientific community at Penn and beyond! @striepenlab @DeBroski1 @KingOfPathogens @pscottlab @CAMBUpenn @PennMicro
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Howitt Lab retweeted
Dr Trevor Lawley@LawleyLab21 Sep 2022
Hello Twitter friends, we are recruiting a post doc to the Lawley Lab (lawleylab.com) work on gut microbiome metabolism of early life bacteria and want to spread the word....link below...please retweet... nature.com/naturecareers/job…
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Interested in unraveling how the #microbiome modulates health and disease? Come join my new lab at @UniJena! We have two #PhDpositions in #ChemicalBiology Synthesis: bit.ly/3JEjIwT Biochemistry: bit.ly/3BP7D5T #chemjobs #chemPhD #ChemTwitter #microverse_exc 1/3
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Stanley Falkow (1934-2018). This week, microbiologist from around the world will gather in Montana to pay respect to this brilliant microbiologist. I am always grateful for what I learned from him. nature.com/articles/d41586-0…

Stanley Falkow (1934-2018)

Nature - Microbe hunter who uncovered how bacteria cause disease.

nature.com
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