@HowittLab

We study the microbiome and its effect on intestinal immunity

 Stanford University
howittlab.com
Joined March 2020
  • Tweets72
  • Following130
  • Followers406
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Howitt Lab retweeted
Long Lab@longlabstanfordOct 22
Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung! cell.com/cell/fulltext/S0092…

MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss

The orphan transporter MCT6 is the route by which the meal- and exercise-associated metabolite Lac-Phe exits intestinal cells and enters the blood. Mice lacking gut MCT6 cannot maintain normal...

cell.com
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Excited to share our work in Science Immunology! Tuft cell signaling remodels the follicle-associated epithelium, influences M cell maturation, and promotes antigen-specific IgA responses. Led by @gabebarron. Thanks @DrRosenIBD & @jakob_moltke! science.org/doi/10.1126/scii…

Follicle-associated epithelial tuft cells amplify type 2 mucosal immunity and IgA production

Two intestinal cell types share developmental traits and combine microbial sensing with antigen delivery to shape antibody responses.

science.org
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Not the first and likely not the last review on tuft cells. But for sure the most recent one, published in @NatRevGastroHep: Kalle and @XiaogangFeng did a great job summarizing recent findings related to tuft cells nature.com/articles/s41575-0… full-text access: rdcu.be/dVaOi
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Congrats Miles on a great talk at FASEB Gastrointestinal Tract XXI. It was our labs first time at this meeting and sure we will be back. #GTSRC24
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Howitt Lab retweeted
Immunity@ImmunityCP22 Jul 2024
Online now: Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation dlvr.it/T9wX6X

Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation

Epigenomic features steering CD8+ T cell heterogeneity across tissues has not yet been extensively explored. By profiling chromatin accessibility changes and gene expression in T cells derived from...

cell.com
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Replying to @UChicago_Micro @GerrickElias
Congratulations Eli! Everyone in the Howitt lab is so excited for you. U Chicago is getting an amazing scientist and colleague.
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Please join us in welcoming our newest faculty member to the University of Chicago Department of Microbiology, Dr. Elias Roth Gerrick @GerrickElias, who will join as Assistant Professor effective September 1, 2024. (1/3)
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Howitt Lab retweeted
Immunity@ImmunityCP13 May 2024
Online now: Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity dlvr.it/T6qpgG

Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity

Intestinal tuft cells are known as sentinels capable of initiating type 2 immune responses upon parasite infections. Ndjim et al. now report a direct effector function for intestinal tuft cells...

cell.com
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careersearch.stanford.edu/jo…
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We're looking for a Research Associate/Technician to join our lab studying microbiome-immune interactions in the gut. We are open to recent college graduates and/or applicants expecting to graduate soon. Previous research experience is helpful, but not required.
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Replying to @schumacherama @Mucus_Man
Beautiful image. I would suspect they're "intermediate cells". We saw them with commensal protist colonization and others have seen with helminth infection. It would be cool to figure out what they do or if they can transition into more canonical Paneth or goblet cells
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Howitt Lab retweeted
Craig Wilen@WilenLab22 Mar 2024
Very excited to share our paper led by @madisonstrine Intestinal tuft cell immune privilege enables norovirus persistence | Science Immunology science.org/doi/10.1126/scii… 1/n

Intestinal tuft cell immune privilege enables norovirus persistence

Colonic tuft cells can intrinsically resist cytotoxic CD8+ T cells, enabling chronic norovirus infection.

science.org
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If you’re interested in host-microbiota interactions but like your microbes with membrane bound organelles then our paper on symbiotic protists is for you @CellCellPress . Congrats @GerrickElias and a huge thank you to all our collaborators! cell.com/cell/fulltext/S0092…

Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competi...

The differing metabolisms of commensal protists and bacteria in the gut microbiome shape the ability of these distinct microbes to interact with and modulate each other and the host immune system.

cell.com
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💥Tenure-Track Faculty Job Alert!💥 Monell has an OPEN SEARCH for MULTIPLE positions (all levels) If you study feeding behavior, metabolism, nutrition, olfaction, taste, chemesthesis, stem cells, or other topic in chemosensory biology, apply! 1/ apply.interfolio.com/79129
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I hadn't thought much about the reptile microbiome before but @GerrickElias curiosity and pet tortoise inspired this story on intestinal protists in wild and domestic reptiles. Big thanks to our collaborators Tim @maddreptiles and Freeland @calacademy journals.asm.org/doi/10.1128…

Commensal protists in reptiles display flexible host range and adaptation to ectothermic hosts |...

Environmental factors like climate change and captive breeding can impact the gut microbiota and host health. Therefore, conservation efforts for threatened species may benefit from understanding how...

journals.asm.org
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Announcing the 2023 Stanford Immunology Preview event! If you’re interested in applying to our PhD program, you’re invited to this virtual event. You’ll hear from our amazing faculty and students about what makes our scientific community so vibrant. bit.ly/stanfordimmpreview23
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Why do intestinal tuft cells sense succinate when it doesn’t appear to help them clear parasites? Our collab with the Salzman lab at MCW sheds some light on this question. Congrats Connie, Lisa, and Gabe @gabebarron for all your great work! @PNASNews pnas.org/doi/10.1073/pnas.22…
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Check out this really cool story from the Moltke Lab @jakob_moltke @TBillipp showing how acetylcholine from tuft cells can regulate epithelial fluid secretion and help clear worm infections from the gut! Excited to have been involved in this incredible work.
Jakob von Moltke@jakob_moltke21 Mar 2023
I am super excited to share @TBillipp's incredible work showing that acetylcholine from tuft cells regulates epithelial fluid secretion across tissues and contributes to helminth clearance from the SI. Thank you to @HowittLab for critical contributions! biorxiv.org/content/10.1101/…

Tuft cell-derived acetylcholine regulates epithelial fluid secretion

Tuft cells are solitary chemosensory epithelial cells that can sense lumenal stimuli at mucosal barriers and secrete effector molecules to regulate the physiology and immune state of their surround...

biorxiv.org
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So grateful to the organizers for making this happen! Whatever your interest in tuft cells, come join us!
Christoph Schneider@ChSchneider_PhD1 Mar 2023
Thrilled to announce the first-ever Tuft Cell Meeting: Aug 28-30, 2023 in Germany. With top speakers, it promises to be a fantastic event. uni-giessen.de/de/fbz/fb11/i… for more information. Don't forget to spread the word! If you have cool work on tuft cells, submit your abstract asap
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In fact, you can see Stanley Falkow’s wonderfully presented and timeless two-part introductory lecture on host-pathogen interactions in this archival footage on YouTube: youtu.be/0RZkgWnLXuI No one has ever explained it more masterfully and I recommend it most highly.
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