Postdoc in the Zhang lab at @broadinstitute and @MIT. Previously @ElowitzLab at @Caltech. Used to go by Grace Chow. 🧬 I luv SynBio!
Cambridge, MA
Joined May 2015
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Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease?
Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)
Huan Edmonds retweeted
Excited to share Minerva, our approach using genome language models for biological discovery! Using Minerva, we find that UG27 reverse transcriptase systems encode variable arrays of diverse ncRNAs with a shared structure, each templating a short DNA hairpin. With @garykbrixi.
Huan Edmonds retweeted
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote
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Huan Edmonds retweeted
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
Huan Edmonds retweeted
Hot off the press! Our latest paper led by @fernpizza , understanding how plasmids evolve inside individual cells. These small pieces of self-replicating DNA live inside bacteria and can transfer antibiotic resistance genes, but they also compete with one another to replicate. 1/
Huan Edmonds retweeted
The Wilkinson Lab is open for science! @MSKCancerCenter
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
Huan Edmonds retweeted
🚨New paper alert!🚨 Cells integrate signals into decision-making. But how do levels of signaling influence cell-fate transitions? Is more always better? Or is there an “optimal” level for cell-fate programming? If we could tune signaling, could optimize production of neurons? Read on! (1/n)🧵
This project was a huge team effort. Shoutouts to:
@maxewilkinson: structure + biochemistry + birb animation 🐦⬛🥚
@HongyuChenChem and @LDangliang: RNA chemistry
@zhangf: incredible mentorship
… and all the amazing authors that worked tirelessly to make this possible. (6/7)
Full story here! doi.org/10.1038/s41467-025-6…
We hope this expands the toolkit of retrotransposon-based gene editors. Also, don’t miss related work from others like @CollinsRNPLab, who have also illuminated how R2 can be used for mammalian genome engineering. (7/7)
Huan Edmonds retweeted
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out
rdcu.be/eq975
Huan Edmonds retweeted
In the latest issue! Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins dlvr.it/TK21Y8
The amount of bizarre political advertisements on my feed is getting out of hand 😳 is it finally time to swap platforms? I am kedmonds.bsky.social, I’ll try to re-add people there too (this feels like getting a new phone in the 2000s).
Huan Edmonds retweeted
The Kappel Lab is opening soon at UCLA and we’re hiring Staff Scientists to help lead our wet-lab projects & to assist with lab management! We have open positions for candidates with a PhD & for recent college grads. Learn more and apply: forms.gle/76inzTL6FoTcRPYo9
Please RT!
Huan Edmonds retweeted
How does one (signaling) arm know what the other is doing in the cell? Through a network of bHLH transcription factors obviously! Our work showing how neural stem cells integrate signals to coordinate a fate response is now out: cell.com/cell-reports/fullte…
Huan Edmonds retweeted
Check out our new review of molecular recording, exploring cutting-edge technologies and their transformative potential for biology. A collaborative effort across multiple labs—proud to have been part of this amazing team! 🌟
The lives of cells, recorded go.nature.com/4g2gRwG #Perspective by @AskaryLab, Wei Chen, @_Choi_Junhong, Lucia Y. Du, @ElowitzLab, @james_gagnon, @schierlab, @sophieseid, @JShendure, @TanjaStadler_CH & @tranmartink
Huan Edmonds retweeted
A dream come true: in 2004 I started thinking about counting microstates to predict gene expression with @JKondev Rob Phillips @HernanGGarcia. 20 years later we can measure them: nature.com/articles/s41586-0… Thank you @WJGreenleaf @bgrdoughty @MichaelaThinks Julia and all co-authors!
