@ILangstein

Biochemist | former PhD student @KorberLab LMU | fascinated by chromatin, yeast & IDRs

 München, Bayern
Joined March 2020
  • Tweets255
  • Following268
  • Followers180
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It's out! I had the most amazing mentors and companions during this journey into the wilderness with @alexholehouse and @KorberLab!
Alex Holehouse@alexholehouse12 Feb 2022
I'm excited to share our new paper - an incredible multi-year collaboration with the incomparable Philipp Korber (@KorberLab) driven by one of the most impressive graduate students I've had the pleasure of working with, Iris Langstein-Skora (@ILangstein) biorxiv.org/content/10.1101/…
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We’re pleased to share our substantially updated (more below on that…) version of our manuscript exploring the relationship between conservation in sequence/function for intrinsically disordered regions (IDRs) biorxiv.org/content/10.1101/…

Sequence- and chemical specificity define the functional landscape of intrinsically disordered...

Intrinsically disordered protein regions (IDRs) pervasively engage in essential molecular functions, yet they are often poorly conserved as assessed by sequence alignment. To understand the seeming...

biorxiv.org
Alex Holehouse@alexholehouse12 Feb 2022
I'm excited to share our new paper - an incredible multi-year collaboration with the incomparable Philipp Korber (@KorberLab) driven by one of the most impressive graduate students I've had the pleasure of working with, Iris Langstein-Skora (@ILangstein) biorxiv.org/content/10.1101/…
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Disordered proteins are ubiquitous and play myriad important roles in biology. The structural form of these proteins can change when the solution environment changes. But does this translate into function? We answer this question in our new preprint: tinyurl.com/3bwm2twf
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Grant Brown@drgrantwbrown13 Aug 2023
It’s Datafest day ⁦@YeastCourseCSHL⁩ !!!
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Siegel Lab@siegel_lab2 Aug 2023
We are happy our review is out! If you are interested in the impact of nuclear organization on antigenic variation, check it out! We discuss the role of nuclear organization in mutually exclusive antigen expression and genome stability. rdcu.be/dic9N @NatureMicrobiol
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Tim Stearns@StearnsLab5 Jun 2023
“I knew I should have streaked for single colonies!” - CSHL Yeast Course t-shirt from late ’90’s Happy summer course season!
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Following the lab’s bird theme, we’re excited to present ALBATROSS; A deep-Learning Based Approach for predicTing pRoperties Of diSordered proteinS).
bioRxiv@biorxivpreprint8 May 2023
Direct prediction of intrinsically disordered protein conformational properties from sequence biorxiv.org/cgi/content/shor… #bioRxiv
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I'm proud to introduce you to the IDRome 👋🍝 We performed simulations of 29,998 IDRs from the human proteome and analysed sequence-ensemble-function relationships. For a quick intro watch 🎞️👇 and then read: biorxiv.org/content/10.1101/…
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Happy Easter! 🐣
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A team led by LMU #molecular biologist Christoph F. Kurat has demonstrated that the way in which #DNA is packaged makes a decisive contribution to a cell’s ability to efficiently double its #genome for cell division. lmu.de/en/newsroom/news-over…
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I realize that I am very fortunate and lucky to have received this ERC grant, so wanted to give a bit of background for the 10-year process it has been for me to get funding from the ERC. This funding came in my fourth attempt. 1/n
Kresten Lindorff-Larsen@LindorffLarsen2 Feb 2023
I am beyond thrilled to announce that we (me 🇩🇰, Eike Schulz 🇩🇪 & Mikael Akke 🇸🇪) have been awarded an ERC Synergy Grant 🇪🇺 🎉 In #DynaPLIX we will combine NMR 🧲, time-resolved crystallography ⚡️ & simulations 🖥️ to study how ligands bind to proteins lth.se/english/article/major…
Picture of Mikael Akke, Kresten Lindorff-Larsen and Eike Schulz, the three PIs in the new ERC synergy grant called DynaPLIX.

ALT Picture of Mikael Akke, Kresten Lindorff-Larsen and Eike Schulz, the three PIs in the new ERC synergy grant called DynaPLIX.

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Ben Sabari@bsabari5 Jan 2023
Excited to share the first paper from my lab. We show that condensates composed of the disordered region of MED1 selectively partition specific functionally related proteins from a complex mixture of biomolecules, regulating gene activation. Free link: authors.elsevier.com/a/1gMr6…
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Never promote overwork. It's not a sign of passion or dedication, it's misguided & deeply unhealthy.
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Kurt Schmoller@SchmollerLab8 Sep 2022
One week left to register and apply for a talk at the #MunichYeastMeeting 2022 @HelmholtzMunich October 10th helmholtz-munich.de/munich-y… @ThePughLab @SophieMartinLab @lab_engel @Dey_Gautam #MYM2022
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#chemieistbunt
JungesChemieForum@JungChemiker7 Sep 2022
Der unter TOP10 eingereichte Antrag wurde soeben mit deutlicher Mehrheit abgelehnt. Vielen Dank an alle Mitglieder, die anwesend waren und die Entscheidung auf eine breite Basis gestellt haben! #chemieistbunt
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Oh the memories 😍
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Chemes Lab@chemeslab10 Aug 2022
Our collaborative work is online today at @NatureSMB! We uncover a simple guiding rule -Conformational buffering: IDP functions are conserved despite large scale variations in sequence by conserving sequence-ensemble relationships. nature.com/articles/s41594-0…
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CSHL YGG@YeastCourseCSHL2 Aug 2022
Photos from late last night, as we work towards perfecting tetrad dissection! #YGG2022
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CSHL YGG@YeastCourseCSHL31 Jul 2022
We are starting to take on *the* yeast genetics challenge! Who will get a perfect plate...? #YGG2022
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Greg Lang@gregoryianlang29 Jul 2022
#YGG2022 @YeastCourseCSHL
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Tim Stearns@StearnsLab19 Jul 2022
Replying to @LacefieldLab @Yeastdoc1 @YeastCourseCSHL
“I knew I should have streaked for single colonies!”
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