@IftachN

Researcher at Tel Aviv University. I like to play with embryo-like models to understand development.

inachmanlab.com
Joined April 2018
  • Tweets219
  • Following188
  • Followers239
4Media
New preprint! These elongating embryo-like structures formed entirely from sheep stem cells in vitro. They develop neural tubes, somites, neurons, and kidney progenitors โ€” modeling post-gastrulation trunk development. ๐Ÿงต๐Ÿ‘‡ 1/8
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Our work is finally published in @Dev_Cell! We predict and affect endodermal morphotype choice in mouse #gastruloids. Great work by @NaamaFa , with key contributions from Chen Sacharen and @LaraAvni. Full paper at authors.elsevier.com/a/1jCamโ€ฆ
Developmental Cell@Dev_Cell4 Jun 2024
Online now: Coordination between endoderm progression and mouse gastruloid elongation controls endodermal morphotype choice dlvr.it/T7qQrb
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Batch correction of single cell sequencing data via an autoencoder architecture by Reut Danino, Iftach Nachman and Roded Sharan doi.org/10.1093/bioadv/vbad1โ€ฆ @IftachN #SingleCellSequencing #Bioinformatics
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Dear American friends. Our Prime Minister has a tendency to lie in his interviews for International media, so I came to help with some facts. Please pass on to your friends - and come help us, Israelis who are fighting for democracy, save our country.
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Iftach Nachman retweeted
FocalPlane@focalplane_jcs5 May 2023
๐Ÿ“ข New post on FocalPlane In our biggest ever preprint list, we highlight #preprints on #bioimageanalysis and new tools and techniques in #imaging over the previous six weeks. focalplane.biologists.com/20โ€ฆ

Microscopy preprints โ€“ new tools and techniques in imaging and bioimage analysis - FocalPlane

Microscopy preprints โ€“ new tools and techniques in imaging and bioimage analysis - Discussions

focalplane.biologists.com
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On Friday, the sun put on a dazzling show for us. My friend @TheVastReaches and I worked hard over the last 5 days to produce this incredibly detailed 140 megapixel image to illustrate how wonderfully dynamic and beautiful our star can be. Make sure you zoom in!
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Our paper is out @ScienceAdvances! Check out how a single line of inner hair cells within the mammalian cochlea๐Ÿš forms. Congrats to the fantastic @roecon91 @ShaharTaiber & Olga Loza. See the thread below. science.org/doi/10.1126/sciaโ€ฆ
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Why are in-vitro embryo-like models so variable, while the embryo develops so robustly? We try to tackle this in a new preprint, using the gastruloid model and morphogenetic progression of definitive endoderm (DE). biorxiv.org/content/10.1101/โ€ฆ

Coordination between endoderm progression and gastruloid elongation controls endodermal morphotype...

Embryos mostly follow a single morphogenetic trajectory, where variability is largely quantitative with no qualitative differences. This robustness stands in contrast to in-vitro embryo-like models,...

biorxiv.org
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more replies
We believe this approach can be extendable to other structures in the gastruloid system, as well as to other organoids for controlling variability, and will also shed light on the factors that provide the embryo its morphogenetic robustness.
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Kudos to @naamafa for bravely leading this effort, and to Chen Schiff for all the machine learning code!
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ืจื‘ื™ื ืฉื•ืืœื™ื ืื•ืชื™, ื—ื™ื™ื, ืื™ืš ื™ื“ืขืช ืœื–ื”ื•ืช ื‘ืžืืžืจืš ืœืคื ื™ ืฉืœื•ืฉื” ืฉื‘ื•ืขื•ืช ืฉื”ื™ืขื“ ื”ื‘ื ืฉืœ ืžื›ื•ื ืช ื”ืจืขืœ ื”ืœื™ื›ื•ื“ื™ืช ื™ื”ื™ื” ื ื’ื™ื“ ื‘ื ืง ื™ืฉืจืืœ (ื•ืจืง ื”ืชื—ืœื ื•)? ื”ืืžืช ื”ื™ื ืฉื”ืชืฉื•ื‘ื” ืงืœื”. ื‘ืงื™ืื•ืช ื‘ืชื•ืœื“ื•ืช ื”ืชื ื•ืขื•ืช ื”ืคืฉื™ืกื˜ื™ื•ืช ื‘ืกืคืจื“ ื•ืื™ื˜ืœื™ื”. ื–ื” ืื—ื“ ืœืื—ื“ ื™ืฉืจืืœ. ื”ื ื’ื™ื“ ื‘ืžื•ื‘ืŸ ื”ื–ื” ื”ื•ื ืจืง ื“ื•ื’ืžื”. ืžื” ื”ื™ืกื•ื“ ืฉืœ ื”ืชื ื•ืขื•ืช ื”ืืœื•?
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Link to the paper (there are many more facts and discussions to read in this excellent Opinion): pnas.org/doi/10.1073/pnas.16โ€ฆ

Science in the age of selfies | PNAS

Science in the age of selfies

pnas.org
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Somitogenesis in a dish from Human pluripotent stem cells ! here come the Somitoids and Segmentoids Olivier Pourquiรฉ @harvardmed & the Axioloids @alevlab .This will help dissecting the mechanisms of human somite formation @Nature rdcu.be/c12OX rdcu.be/c12Ph
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Iftach Nachman retweeted
Itai Yanai
@ItaiYanai30 Nov 2022
Knowing how to give a good talk is a crucial skill to have, but it's mostly not formally taught very well. Here's a ๐Ÿงตon my strategy for how to prepare for the presentation, actually present it, and then answer the questions.
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Iftach Nachman retweeted
Miki Ebisuya@EbisuyaMiki26 Nov 2022
Our review on synthetic developmental biology is out @ScienceMagazine! @GMartinezAra and @KStapornwongkul discussed what developmental processes have been reconstituted/controlled so far and what tools/approaches will be the key in the next stages. science.org/doi/10.1126/scieโ€ฆ

Scaling up complexity in synthetic developmental biology

The application of synthetic biology approaches to study development opens the possibility to build and manipulate developmental processes to understand them better. Researchers have reconstituted...

science.org
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Wow! Scientists have observed a single-cell alga evolve in real time into a multicellular organism. The transition took around a year and was caused by the introduction of a predator into the environment. nature.com/articles/s41598-0โ€ฆ
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Iftach Nachman retweeted
Kitchen Lab@KitchenLab52 Oct 2022
In case you are wondering about how to kick start your week. Here is the interview of our dearest developmental biologist @AMartinezArias youtu.be/ajf1U-sZpzc #development #sciencetwitter #AcademicTwitter
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