@IonChannelLeeds

Ion channel research at the University of Leeds. Tweeting our publications and updates from our laboratories.

 Leeds, England
ionchannels.leeds.ac.uk
Joined July 2016
  • Tweets112
  • Following76
  • Followers453
Ion Channels @Leeds retweeted
Ion Channel Library@ionchannellib25 Jun 2021
Upcoming Webinar - Tuesday 29th June at 14.00 BST @DrJonLippiat will talk about the discovery of KNa1.1 (KCNT1, SLACK, Slo2.2) channel inhibitors using virtual screening and CryoEM structures. If interested, register here: lnkd.in/e4QmeHA #ionchannels @Metrion_Biosci
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Ion Channels @Leeds retweeted
Jon Lippiat@DrJonLippiat12 Apr 2021
Any channel-lovers looking for a job? We have a postdoc position available on a project to characterise our next set of novel KCNT1 potassium channel inhibitors. Deadline 28 April. #KCNT1 #ionchannels #epilepsy jobs.leeds.ac.uk/vacancy.asp…

Jobs at the University of Leeds

jobs.leeds.ac.uk
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Ion Channels @Leeds retweeted
Pliotas Group@PliotasGroup25 Nov 2020
In our new RSC review we accumulated DEER/PELDOR studies of membrane proteins over 15 years ABC/Multidrug/Secondary transporters, to GPCRs, SEC transloc, Photosynth. & Mitochondr, OMPs, ion channels et al, combined with multiple lipid mimics and MD tools : pubs.rsc.org/en/content/chap…
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Ion Channels @Leeds retweeted
Robin Bon@RSBon_Lab23 Nov 2020
Proud that our work on understanding small-molecule modulation of #TRPC channels by #CryoEM has now been published in @CommsBio. Great work driven by @scidave with @chmkjs @RachelJ9908 @profdbeech @stemuench from @UoL_LICAMM @AstburyCentre @Astbury_BSL. rdcu.be/cbbn1
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Another collaboration between Leeds ion channel and virology groups.
Jon Lippiat@DrJonLippiat28 Oct 2020
New publication: TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection thorax.bmj.com/content/early… #ionchannels
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Ion Channels @Leeds retweeted
Jian Shi@JianShi_Leeds6 Oct 2020
Delighted to share our latest work published today in @CellReports on how intrinsically rapidly-inactivated PIEZO1 channels sense sustained mechanical force such as blood flow in endothelium. Thanks to our team in @unileedscardio and Toulouse. cell.com/cell-reports/fullte…

Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels

The vascular endothelial response to blood flow involves sustained activation of mechanically activated PIEZO1 channels; yet, PIEZO1 has an intrinsic rapid inactivation gate that should prevent...

cell.com
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Patch-clamp: Long shot; anyone know a patcher in the Liverpool area up for some short term/part time single-channel WORK on a great but easy project!? Even PhD student as part-time casual OK if can patch!! #ionchannels @Channelomics @RainbowLabUoL @ClaireMemimo @david_colquhoun
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Ion Channels @Leeds retweeted
Pliotas Group@PliotasGroup26 Jun 2020
@Bela_Bode @mayue3691 @LeedsIMB @IonChannelLeeds @AstburyCentre @ScienceLeeds @EPR_ESR @Channelomics
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Ion Channels @Leeds retweeted
Sam Dobson@samjdobson11 May 2020
Please to announce my first first author paper is out now in Antiviral Research! Looking at the role of ion channels during the entry of the polyomaviruses SV40 and MCPyV sciencedirect.com/science/ar…
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Local Ca2+ signals couple activation of TRPV1 and ANO1 sensory ion channels stke.sciencemag.org/content/…
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Ion Channels @Leeds retweeted
Jon Lippiat@DrJonLippiat25 Apr 2020
It's published! #ionchannels #kcnt1 #epilepsy @Beth_aimee_cole @RachelJ9908 @jeff_dddd @FishwickGroup @stemuench
iScience@iScience_CP25 Apr 2020
Structure based identification and characterisation of inhibitors of the epilepsy associated KNa1.1 (KCNT1) potassium channel cell.com/iscience/fulltext/S…
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Ion Channels @Leeds retweeted
Jian Shi@JianShi_Leeds21 Apr 2020
I am delighted to join the editorial board of The Journal of Physiology (the most prestigious and leading journal on physiology since 1878) as an editorial board fellow. Look forward to working with you @JPhysiol to serve the whole community.
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Ion Channels @Leeds retweeted
Robin Bon@RSBon_Lab18 Apr 2020
Very proud to share the first #CryoEM studies by our @UoL_LICAMM @AstburyCentre #TRPC team: Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. biorxiv.org/content/10.1101/…

Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a...

TRPC1/4/5 channels are non-specific cation channels implicated in a wide variety of diseases, and TRPC1/4/5 inhibitors have recently entered the first clinical trials. However, fundamental and...

biorxiv.org
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We're delighted that @RohacsTibor is visiting us today. He will be delivering his seminar on "Regulation of TRPM Channels by G-proteins and phosphoinositides" at 2pm in RSLT23.
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New #ionchannels publication from Leeds researchers @PliotasGroup and @DrJonLippiat featuring PELDOR/DEER spectroscopy and patch clamp of reconstituted mechanosensitive channels.
Pliotas Group@PliotasGroup10 Oct 2019
Pleased to see our study in @NatureComms. We show the high threshold mechanosensitive channel could be allosterically modulated nature.com/articles/s41467-0… @AstburyCentre @LeedsIMB @IonChannelLeeds @Bela_Bode @DrJonLippiat @StAndrewsBSRC @ScienceLeeds @SchoolofBiology @news_RSE
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New research posted as a #preprint from our Ion Channel and Membrane Protein structural biology teams @LeedsIMB
Jon Lippiat@DrJonLippiat27 Sep 2019
First #preprint alert. Are cryo-EM structures any good in virtual HTS for ion channel modulators? #KCNT1 #ionchannels #epilepsy @beth_aimee_cole @RachelJ9908 @stemuench @jeff_dddd @FishwickGroup @AutifonyLtd biorxiv.org/content/10.1101/…

Structure-based identification and characterisation of novel inhibitors of KNa1.1 potassium...

Several types of drug-resistant epileptic encephalopathies of infancy have been associated with mutations in the KCNT1 gene, which encodes the sodium-activated potassium channel subunit KNa1.1. These...

biorxiv.org
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#PLOSCompBio: Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entra ... dx.plos.org/10.1371/journal.…
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#PLOSNTDs: Chikungunya virus requires cellular chloride channels for efficient genome replication dx.plos.org/10.1371/journal.…

Chikungunya virus requires cellular chloride channels for efficient genome replication

Author summary Chikungunya virus (CHIKV) is a mosquito-borne virus that infects humans and causes chikungunya fever—characterized by fever, rash and chronic arthralgia. Treatment of chikungunya fever...

journals.plos.org
A Mechanism for Statin-Induced Susceptibility to Myopathy sciencedirect.com/science/ar…
A cytoplasmic Slo3 isoform is expressed in somatic tissues @drjonlippiat rdcu.be/bQWLe
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