@LeedsIMB

An interdisciplinary research theme in the School of Biomedical Sciences at the University of Leeds, focussing on membrane proteins in health and biotechnology.

 Leeds, U.K.
biologicalsciences.leeds.ac.uk/integrative-membrane-biology
Joined September 2019
  • Tweets15
  • Following21
  • Followers99
Leeds Integrative Membrane Biology retweeted
Pliotas Group@PliotasGroup5 Jan 2022
In our latest article we found structural correlation between pocket modification and tension activation in the MscL channel using pulsed EPR, HDX and MD: cell.com/structure/fulltext/… @Bolin83814396 @95bjl @anton_calabrese @FrankSobott @KalliGroup @EPR_ESR @RSC_ESR @AstburyCentre

Pocket delipidation induced by membrane tension or modification leads to a structurally analogous...

Wang et al. demonstrate that delipidation of the MscL channel pockets by either membrane tension or modification stabilizes a structurally analogous expanded state. This is a crucial state in the...

cell.com
Anton Calabrese@anton_calabrese4 Jan 2022
Really pleased to see this online today in @Structure_CP - fantastic work led by @Bolin83814396 @95bjl @PliotasGroup on the role of lipids and membrane tension in modulating the mechanosensitive ion channel MscL @KalliGroup @MassSpecLeeds @AstburyCentre sciencedirect.com/science/ar…
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Leeds Integrative Membrane Biology retweeted
Pliotas Group@PliotasGroup1 Apr 2021
Check out our new preprint: Mechanical and molecular activation lead to structurally analogous MscL states biorxiv.org/content/10.1101/… Great effort by @Bolin83814396 & @95bjl, @FrankSobott @anton_calabrese @KalliGroup at @AstburyCentre @ScienceLeeds @LeedsIMB @MassSpecLeeds

Mechanical and molecular activation lead to structurally analogous MscL states

The mechanosensitive channel of large conductance MscL gates in response to tension changes in the membrane to allow the exchange of molecules through its pore. Native ligands that bind and modulate...

biorxiv.org
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Leeds Integrative Membrane Biology retweeted
Stephen Muench@stemuench26 Jan 2021
Took a while to get around the preferred orientation of HSPD1 but good to see the hard work of @DavidKlebl and the team @MatthewFeasey @HeskethEmma @RSBon_Lab @naranson @FrankSobott finally out. cell.com/iscience/fulltext/S…

Cryo-EM structure of human mitochondrial HSPD1

Molecular Biology; Molecular Structure

cell.com
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Leeds Integrative Membrane Biology retweeted
Jannik Strx@Jannik_Strx16 Sep 2020
So excited to see IMPROvER finally published!!! First first authorship together with @Steve_Harborne and @JessicaJCB_ 🍾 Give it a go and stabilise your most loved/hated membrane protein :) nature.com/articles/s41598-0…
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Leeds Integrative Membrane Biology retweeted
Biophysical Journal@BiophysJ30 Jul 2020
#OPENACCESS: "In-Lipid Structure of Pressure-Sensitive Domains Hints Mechanosensitive Channel Functional Diversity" by Charalampos Kapsalis et. al. cell.com/biophysj/fulltext/S… @PliotasGroup @Bela_Bode @mayue3691 @LeedsIMB @AstburyCentre @ScienceLeeds @StAndrewsBSRC

In-Lipid Structure of Pressure-Sensitive Domains Hints Mechanosensitive Channel Functional Diversity

The mechanosensitive channel of large conductance (MscL) from Mycobacterium tuberculosis has been used as a structural model for rationalizing functional observations in multiple MscL orthologs....

cell.com
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Leeds Integrative Membrane Biology retweeted
Stephen Muench@stemuench16 May 2020
It started out as a 10 week rotation project looking at particle behaviour in the ice, over 1 year later we finished it! Thanks to lots of people @DavidKlebl @Bex_16 @MDarrow7 @Molly_Gravett @michkouros @DCFMonteiro and more.. biorxiv.org/content/10.1101/…

Need for speed: Examining protein behaviour during cryoEM grid preparation at different timescales

A host of new technologies are under development to improve the quality and reproducibility of cryoEM grid preparation. Here we have systematically investigated the preparation of three macromolecu...

biorxiv.org
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Leeds Integrative Membrane Biology retweeted
Jon Lippiat@DrJonLippiat25 Apr 2020
It's published! #ionchannels #kcnt1 #epilepsy @Beth_aimee_cole @RachelJ9908 @jeff_dddd @FishwickGroup @stemuench
iScience@iScience_CP25 Apr 2020
Structure based identification and characterisation of inhibitors of the epilepsy associated KNa1.1 (KCNT1) potassium channel cell.com/iscience/fulltext/S…
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Leeds Integrative Membrane Biology retweeted
Robin Bon@RSBon_Lab18 Apr 2020
Very proud to share the first #CryoEM studies by our @UoL_LICAMM @AstburyCentre #TRPC team: Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. biorxiv.org/content/10.1101/…

Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a...

TRPC1/4/5 channels are non-specific cation channels implicated in a wide variety of diseases, and TRPC1/4/5 inhibitors have recently entered the first clinical trials. However, fundamental and...

biorxiv.org
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Leeds Integrative Membrane Biology retweeted
Goldman Lab@GoldmanLab6 Jan 2020
We’ve got an exciting #postdoc opportunity working on #membraneprotein #structuralbiology in close collaboration with @LarsJeuken @PliotasGroup and Dr Antreas Kalli! Check it out here and please encourage anyone that could be interested to apply: jobs.leeds.ac.uk/vacancy.asp…

Jobs at the University of Leeds

jobs.leeds.ac.uk
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Leeds Integrative Membrane Biology retweeted
Goldman Lab@GoldmanLab18 Nov 2019
Excited to announce that the Goldman Lab will be coming to Public Engagement Events Near You in March 2020 #AstburyConversation20 #BeCurious20
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A cryo-EM grid preparation device for time-resolved structural studies doi.org/10.1107/S20522525190…
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New publication from Integrative Membrane Biology by @PliotasGroup and @DrJonLippiat
Pliotas Group@PliotasGroup10 Oct 2019
Pleased to see our study in @NatureComms. We show the high threshold mechanosensitive channel could be allosterically modulated nature.com/articles/s41467-0… @AstburyCentre @LeedsIMB @IonChannelLeeds @Bela_Bode @DrJonLippiat @StAndrewsBSRC @ScienceLeeds @SchoolofBiology @news_RSE
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Leeds Integrative Membrane Biology retweeted
Pliotas Group@PliotasGroup4 Oct 2019
Great cover image by Dario de Vecchis and @antreaskalli group for their study on Band3 featured in Biophysical Journal @AstburyCentre @LeedsIMB
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Leeds Integrative Membrane Biology retweeted
Goldman Lab@GoldmanLab26 Sep 2019
our final year @wellcometrust phd student ROTOR thesis!! Congratulations @brendanfarrell #thesistheend
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New #preprint from our Integrative Membrane Biology group.
Jon Lippiat@DrJonLippiat27 Sep 2019
First #preprint alert. Are cryo-EM structures any good in virtual HTS for ion channel modulators? #KCNT1 #ionchannels #epilepsy @beth_aimee_cole @RachelJ9908 @stemuench @jeff_dddd @FishwickGroup @AutifonyLtd biorxiv.org/content/10.1101/…

Structure-based identification and characterisation of novel inhibitors of KNa1.1 potassium...

Several types of drug-resistant epileptic encephalopathies of infancy have been associated with mutations in the KCNT1 gene, which encodes the sodium-activated potassium channel subunit KNa1.1. These...

biorxiv.org
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