@JanekG9

Developer & Scientist at BioNTech (mRNA x AI) | Building in stealth (next-gen infrastructure for controlling tiny liquid volumes)

Joined November 2020
  • Tweets24
  • Following478
  • Followers33
New Post on Cancer Vaccines They've yet to become a systematic science despite decades of work, 200 trials + an exciting Moderna PII We @CompoundVC are excited about more comprehensive assays (full genome sequencing, more relevant readout, etc), novel target spaces & manuf leaps
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This is an excellent way to use o3. Hadn't realised it does tasks as well which makes a lot more interesting stuff possible.
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JanekG retweeted
Zygi
@nonagonono2 Apr 2025
Replying to @orthonormalist
oops, fixed. Now we get that nice straight line
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Huge cancer breakthrough! mRNA vaccine (similar to COVID vaccine tech) shows stunning results against pancreatic cancer! 75% of responsive patients STILL cancer-free at 3 yr, normally 80% recur. Could revolutionize treatment for one of deadliest cancers! Funded in part by @NIH
Vinod BalachandranMD@TheVinodLab19 Feb 2025
#mRNAvaccines for #PancreaticCancer (PDAC) PART4 1. Out today in @Nature nature.com/articles/s41586-0… 🧵👇🏽 [1/23]

RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer

Nature - In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited...

nature.com
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Our latest preprint is out: medrxiv.org/content/10.1101/… "Simvastatin therapy in different subtypes of hypercholesterolemia - a physiologically based modelling approach." #SBML #PKDB @qualiperf
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Back on track: #Germany is heading into 2023 with #gas reserves close to 90%. We could manage an extremely cold January/February now. Storages may end up at >70% in March. Essentially, we are already solving the problem of next winter these days. zeit.de/wirtschaft/energiemo…
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How does CYP2D6 genotype effect metabolic phenotyping? See our latest paper for some answers. Amazing work by @JanekG9 using #PBPK modeling: frontiersin.org/articles/10.… Funded by @qualiperf and #lisym.
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Our latest preprint is out studing the effect of CYP2D6 polymorphism on dextromethorphan biorxiv.org/content/10.1101/…. Amazing work by @JanekG9 funded by @qualiperf. #PBPK #SBML

Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for...

The cytochrome P450 2D6 (CYP2D6) is a key xenobiotic-metabolizing enzyme involved in the clearance of many drugs. Genetic polymorphisms in CYP2D6 contribute to the large inter-individual variability...

biorxiv.org
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Replying to @liviapuljak
@liviapuljak and colleagues find that only 6.8% of contacted authors of papers in open-access journals with a statement indicating data are available on request provided the data upon request. It is clear that data availability statements are meaningless. doi.org/10.1016/j.jclinepi.2…
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Our analysis of the pharmacokinetics of caffeine is out frontiersin.org/articles/10.…. Great work by @JanekG9 #lisym #qualiperf #simliva
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Es muss jetzt den Ausschluss Russlands aus #SWIFT geben! Wenn Deutschland diese zentrale Sanktion verhindert, wird #Putin der Weg bereitet, seinen Krieg in #Europa auszuweiten. Herr @Bundeskanzler, heben Sie heute im #EUCO die Hand für die entscheidende Sanktion gegen #Russland!
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15 Data Fallacies and How to Avoid Them geckoboard.com/best-practice…
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Our latest preprint is out. biorxiv.org/content/10.1101/… Great work by @JanekG9 et al.

Pharmacokinetics of caffeine: A systematic analysis of reported data for application in metabolic...

Caffeine is by far the most ubiquitous psychostimulant worldwide found in tea, coffee, cocoa, energy drinks, and many other beverages. Caffeine is almost completely metabolized in the liver by the...

biorxiv.org
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Die Wahrheit ist nicht relativ zeit.de/kultur/2021-04/wisse… via @zeitonline
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