Director of Genomics Research, Center for Population Genomics. Boston VA. MVP. CVD & Blood Genetics. Canada ➡️ Edinburgh ➡️ Boston. Opinions are my own.
Boston, MA
Joined September 2015
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Really excited to have this out as a follow-up to our initial discovery paper. @Saketh_Challa1 explores how CD36 variant stacks up against other known cardiomyopathy genes. @KrishnaAragam @VAORD
Among individuals of African ancestry, a common #CD36 nonsense variant was associated with higher risk of dilated #cardiomyopathy in a dose-dependent pattern, with homozygous carriers having approximately 5-fold higher risk.
In 4 US cohorts, this variant accounted for more of the dilated cardiomyopathy burden than #TTN truncating variants, indicating that current genetic frameworks may miss a major contributor in this population.
ja.ma/3Wy9k40
Some of the most exciting work I have had the privilege to be involved in and one of my favorite collaborations. Thanks to all the participants who made this possible. @DeptVetAffairs @VAResearch #MVP
Today in @NatureGenetics, we report the discovery of a common CD36 variant specific to individuals of African ancestry that increases risk of DCM, and may help explain the ~2x higher rate of DCM/heart failure in this population
nature.com/articles/s41588-0…
Dr. Jennifer Huffman retweeted
The Million Veteran Program is the @DeptVetAffairs' gift that keeps on giving...critical clues to the etiology and treatment of coronary disease, the #1 cause of death worldwide. Thank you U.S. Veterans and program leadership for making this possible. Let's keep it going!
"Among all the uncertainty, you can always count on awesome science to make you smile. Check out our latest @CellCellPress interdisciplinary endeavor—a reminder that we all have a 🫀, whether right-dominant or not! sciencedirect.com/science/ar…
Dr. Jennifer Huffman retweeted
Once in a lifetime opportunity - incredible science with the BEST people
Envision yourself as a member of this team? Come join our group to pursue research at the interface of megakaryocyte biology and translational medicine.
@JosepItaliano
NIH-funded post-doc positions available to study platelet production + the other functions of megas #hematology
Dr. Jennifer Huffman retweeted
I'm honored to have the opportunity to discuss our recent work, check it out!
.@HGGAdvances sat with Sophia Gunn, PhD, in the latest "Inside HGGA" to discuss her recently published paper, “Comparison of methods for building polygenic scores for diverse populations.” ➡️ashg.org/hgga/inside-hgg-adv…
#ASHG #GeneticsDiscoveries #HumanGenetics
Dr. Jennifer Huffman retweeted
Probably the most important paper I will ever write link.springer.com/article/10… @stevesphd @BMCMedicine
Dr. Jennifer Huffman retweeted
Following our discovery in humans for a role of GRK5 in platelets (cell.com/ajhg/fulltext/S0002…), glad to report platelet-specific knockout of Grk5 also modifies thrombin activation and thrombosis: rpthjournal.org/article/S247…
Dr. Jennifer Huffman retweeted
I'm often asked about the latest GWAS datasets for different cardiovascular traits🧬
🔗This is my list with links to the most recent and largest publicly available GWAS summary statistics for cardiometabolic traits❗️
docs.google.com/spreadsheets…
Dr. Jennifer Huffman retweeted
A large-scale genome-wide association study in Science using data from the Million Veterans Program—one of the largest U.S.-based biobanks—fills crucial knowledge gaps of the relationships between genes, traits, and disease across diverse populations.
scim.ag/7IB
So excited to finally be able to share this work broadly. It was an incredible team to work with and I can't wait to see what the global research community produces from this data.
I’m thrilled to share that our work from the @VAResearch is finally out in @ScienceMagazine ! We dive deep into the genetic architecture of 2,068 traits using data from the VA Million Veteran Program, comprising 635,969 Veteran.
science.org/doi/10.1126/scie…
Dr. Jennifer Huffman retweeted
Please share: Professor or Senior Lecturer position in Quantitative Genomics
elxw.fa.em3.oraclecloud.com/…
Dr. Jennifer Huffman retweeted
Three/four exciting 4-year computational post-doctoral positions in our team @humantechnopole to work on a variety of projects. Please retweet and share within your networks.
Dr. Jennifer Huffman retweeted
Thrilled for the opportunity to learn from researchers & #researchparticipants in tomorrow’s workshop #ReturnofResearchResults. Thank you @iftikhar_kullo & Dr. Carol Horowitz for helping Develop an exciting program.
#geneticinformation #precisionmedicine
#bioethics @nih_nhlbi
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Dr. Jennifer Huffman retweeted
A single SNP in ~10% of US African Ancestry individuals causes a systematic decrease in HbA1c and a dramatic under treatment of diabetes. In @NatureMedicine led by @JosephBreeyear @JackieHellwege @genepiman_giri @toddledwards @VUMCDiscoveries nature.com/articles/s41591-0…
Dr. Jennifer Huffman retweeted
#RPTH Original Article: Authors report on factors modulating #platelet reactivity from a large population using 5 different assays
@drmelchan @Florian_Th @Nkambuleb @JGfutureMD25 @zoeschneider112 @JennyGenetics @Plateletpaul @proftimwarner @ADJomics
Read rpthjournal.org/article/S247…
It was a delight to work with this talented team and great to see this available for others to use!
Preprint from the @DeptVetAffairs collaboration with @doescience. Using supercomputers and GPUs from @ORNLComputing to accelerate analyses for biobanks with data from the Million Veteran Program @VAResearch. Joint work with @_anuragverma @weizhouw @JennyGenetics et al.
Dr. Jennifer Huffman retweeted
Fantastic work by Dr Dobson @BloodBiology. Thank you @JTHjournal for highlighting this study!
Dr. Jennifer Huffman retweeted
End of an era_last Framingham Heart Study Original Cohort Participant died Sept 25th after celebrating her 105th birthday!!
How one health study, inspired by FDR's death, changed life in America forever usatoday.com/story/news/heal… via @usatoday
Dr. Jennifer Huffman retweeted
Fantastic effort by PhD student in my lab, Meghan Mulligan! @GeneticsOtago
Latest publication from Otago Biochemistry:
The molecular genetics of nELAVL in brain development and disease
nature.com/articles/s41431-0…
So excited this is live! Really proud of this collaboration and all the results we will be making live to the public in the next few months! @_anuragverma @madduri @damrauer @VAResearch #VA_MVP medrxiv.org/content/10.1101/…