@JoeNFrost

Postdoctoral immunologist @sloan_kettering Tregs and inflammation // previously iron and immunity @Drakesmith_Lab @MRC_HIU @UniofOxford

Joined September 2020
  • Tweets131
  • Following440
  • Followers274
8Media
1/ I’m hugely excited to be able to share with you our paper ‘hepcidin-mediated hypoferremia disrupts immune responses to vaccination and infection’ @MedCellPress cell.com/med/fulltext/S2666-… Thank you @Drakesmith_Lab @MRC_HIU @MRC_WIMM + our global collaborators! #Tweetorial time:

Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection

Iron deficiency is very common in humans and animals. Frost et al. demonstrate that low concentrations of iron in serum, caused by the hormone hepcidin, inhibit the body’s response to vaccines and...

cell.com
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Two new contributions from us: @MeganRTeh on the wild metabolism of CD8 T-cells in iron deficiency and why they love aspartate; and the current landscape of the strong influence of iron on immunity in general, with @JoeNFrost nature.com/articles/s41577-0… nature.com/articles/s41467-0…
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Our paper on PM abundance as a regulator for myeloid function is out at SI science.org/doi/10.1126/scii…!  I would like to thank my mentors Morgan Huse, Orion Weiner, and Jason Cyster and my labmates in @huselab The Morgan Huse Laboratory, @OWeinerLab, and Cyster labs.

Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells

Plasma membrane abundance controls myeloid cell phagocytosis, migration, and in vivo responses against fungal pathogens.

science.org
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Thrilled to have this story out online @ImmunityCP!! Together with @SunLab_Official, we highlight how dietary fasting improves NK cell anti-tumor immunity and examine the tissue-specific processes that drive these improved responses 🧵cell.com/immunity/fulltext/S…

Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity

Dietary restriction is associated with improved elimination of cancer cells, and fasting regimens are being tested in clinical settings in combination with cancer therapies. Using a cyclic fasting...

cell.com
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Great thread from Felix on @sarah_wideman ‘s amazing recent paper. Sarah makes us ask what’s happening to the host immune response when we think about iron availability and malaria! It was a lot of fun working with them both and seeing this story develop.
Felix C Richter@CleeteRichter28 Oct 2023
I am really glad to highlight a fantastically thorough paper from @sarah_wideman and the @Drakesmith_Lab which I was allowed to have a small role in. It highlights the central role of cellular #iron levels in host cells during #malaria. A thread🧵 journals.plos.org/plospathog…👇

Cellular iron governs the host response to malaria

Author summary Malaria is a serious and potentially lethal infectious disease that affects nearly 250 million people each year. It is caused by Plasmodium species parasites that are transmitted...

journals.plos.org
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Interferon-γ couples CD8+ T cell avidity and differentiation during infection nature.com/articles/s41467-0…

Interferon-γ couples CD8+ T cell avidity and differentiation during infection

Nature Communications - Although IFN-γ is known to regulate T cell function and expansion during virus-specific responses, its impact on T cells with varying avidity for antigen remains...

nature.com
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Hi everyone, I’m excited to share a pre-print of my postdoc work 🍾biorxiv.org/content/10.1101/… We found a protein (Gb4) that allows immune cells to move after ”eating”. Normal innate immune cells (red) stop moving to prevent pathogen spreading, but cells lacking Gb4 keep migrating.
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Congratulations to IMP graduate student Deeksha Deep @deeksha_deep in Sasha Rudensky’s lab on the successful defense of her thesis work! Way to go Dr. Deep!! 🥳🙌🏻🥂
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Excited to share our work in @NatureImmunol on synovial fibroblasts in rheumatoid arthritis! A wonderful collab between @HSpecialSurgery + @MSKCancerCenter with @GaoVianne @DonlinLab, Tom Norman, Christina Leslie and Sasha Rudensky. nature.com/articles/s41590-0…

Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis

Nature Immunology - Smith et al. present a resource detailing drivers of transcriptional heterogeneity of synovial fibroblasts cell states in the inflamed joints of human patients with rheumatoid...

nature.com
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What does melanoma do with all that fat? Incredibly excited to share that our work on lipid droplets in melanoma is finally out! nature.com/articles/s41467-0…

Lipid droplets are a metabolic vulnerability in melanoma

Nature Communications - Lipid droplets are a dynamic organelle found in a variety of cell types, most prominently in adipocytes. Here, the authors find in zebrafish and human cells that lipid...

nature.com
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This is corroborated by NHS data, which shows that the huge increase in voluntary resignations over the past two years has been driven by people citing problems with their work-life balance.
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Joe Frost retweeted
dana_peer@dana_peer1 May 2023
Thrilled to share our new paper, jointly with Sasha Rudensky, spearheaded by Ari Glasner, Sam Rose and Roshan Sharma. While deleting genes is the current rave, this paper shows the awesome power of deleting entire cell types, T-regs in this example: rdcu.be/da7x1
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Joe Frost retweeted
Yiran Meng@YRMeng1 May 2023
Excited to share that my postdoctoral work is finally out @NatureCellBio, thanks to all the great people @Simona66274422 @SThongjuea I've been working with @UniofOxford @MRC_WIMM. What a journey! nature.com/articles/s41556-0…
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Extremely honored to have joined the #charter #dinner @StEdmundHall last night and represent @IngenzaLtd at this fabulous event. Thank you very much @JackTan19 for the invite. It is a real pleasure working with you and @UniofOxford on innovative vaccines
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Andrew Pollard nails it again: The UK's NHS has transformed healthcare by training clinical research leaders, but they must have protected time to deliver. This cannot be achieved while doctors and nurses are drowning in a chronically understaffed system. theguardian.com/commentisfre…

Britain’s Covid research led the world – why have our clinical trials fallen off a cliff? | Andrew...

Pressures on the NHS, a lack of doctors and post-Brexit delays are hampering our ability to develop cutting-edge drugs, says Prof Sir Andrew Pollard, director of the Oxford Vaccine Group

theguardian.com
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📢🙏 share and help us to find a motivated PhD candidate for an 🤯🤓🤩 opportunity at @CancerImmunoAMU 🧪🧠 Exciting #PhD call in #PediatricOncology! to advance #Medulloblastoma research using innovative single-cell metabolomic profiling! @SCENITHmetab #ImmunoMetabolism 1/ – at Marseille, France
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#WednesdayMotivation is to continue celebrating 2023 #WomensHistoryMonth! Today we highlight Adriana Mujal, PhD (@amujal) a #MSKPostdoc from the @SunLab_Official. #WomenInSTEM
“Adriana is incredibly smart, scientifically brilliant, and also a terrific colleague. Her ability to be balance her professional and personal life is amazing while also having time for students, techs, and other postdocs in the lab is truly inspiring.” - Rebecca Delconte, PhD Adriana Mujal, PhD Postdoctoral Researcher Sun Lab

ALT “Adriana is incredibly smart, scientifically brilliant, and also a terrific colleague. Her ability to be balance her professional and personal life is amazing while also having time for students, techs, and other postdocs in the lab is truly inspiring.” - Rebecca Delconte, PhD Adriana Mujal, PhD Postdoctoral Researcher Sun Lab

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Really glad my PhD work is now released. Here is the promised 🧵. In the @aksimonlab, we have been investigating for a long time, how autophagy, the cellular recycling mechanism, controls immunity. However little is known how autophagy in non-immune cells impacts #immunity.
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I am very happy to see my first first-author paper published @embojournal, very excited to see the main work of my #PhD now online. A detailed 🧵is coming soon. In short, we found that #adipocyte #autophagy limits gut inflammation by IL-10 and oxylipins. doi.org/10.15252/embj.202211…

Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL‐10

The EMBO Journal - Lipids play a major role in inflammatory diseases by altering inflammatory cell functions, either through their function as energy substrates or as lipid mediators such as...

link.springer.com
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We are hiring - postdoc positions available! If you are interested in joining a highly collaborative and supportive team to study immune tolerance, host-microbiota interactions and early life immunity, see link below for details! Please RT! thebrownlaboratory.com/conta…
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