It's time we rewrite the social contract for the 21st century. △▼ A project from @analog_kyle △▼
Joined September 2025
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Hosted by @analog_kyle , produced by @rayanhindi , and directed by Lancelot Bernheim , State Change Season 1 has taken us on an extraordinary journey into the outer edges of human possibility.
From cryopreservation to rewriting our genes, from space exploration to AI doppelgängers, from mapping the mind to putting democracy under stress — this season explored what happens when science fiction starts becoming reality.
Thank you to all our guests for making this first season possible.
@emilkendziorra
@CathyTie
@santisiri
@b_belvisi
@arthaud_
@alexisthual
@tomorrowbio
@InterstellarLA
And to all our teams in Paris, New York and Buenos Aires
Stay tuned for season 2
#singularity #futuretech #humanity #ai #science
👀👀👀
We're thrilled to announce the Superpower Peptide Library.
Every peptide, mapped to the body.
152 peptides, from approved drugs to compounds still in trials, sorted by where they act.
Each one has its own page, reviewed by a physician and fully cited, covering:
- the evidence and how strong it is
- its FDA status
- it's mechanism of action
- what studies in humans have found
Because not all peptides are equal.
Semaglutide is FDA-approved. BPC-157, maybe the most talked-about peptide for recovery and repair, is not. In a 2025 review of its research, 35 of 36 studies were in animals or the lab.
Know the science before you buy the hype.
Check it out here:
superpower.com/guides/peptid…
Sleep less, look younger, build muscle, think faster.
@maxmarchione says there will be a peptide for each. Ozempic is just the blueprint for everything coming next.
Full episode in link in bio
New episode out now on YouTube: Peptides, AI Doctors and the End of the Annual Physical.
@maxmarchione founder of @superpower , joins @analog_kyle to talk about moving medicine from treating sickness to preventing it, through comprehensive diagnostics and AI-driven care.
They discuss who will build the “Apple of healthcare”, which AI lab is best placed to win in health, and what medicine looks like in 5 years.
Full episode, link in bio.
State Change retweeted
> organoids in space
> the darwinian drive towards human enhancement
> calibrating your peptide protocol
> maximizing experience per unit time
a wide-ranging conversation with @maxmarchione on building AGI for your health.
Find it on @JoinStateChange.
We quietly redefined what a healthy human is supposed to look like
Full breakdown of what's actually normal vs optimal on State Change's YouTube
Democracy was never meant to be finished, it's a machine for manufacturing legitimacy under pressure.
Santiago Siri breaks down why the hardest decisions, not the easy ones, are the real test of the system.
Full conversation on State Change's YouTube channel.
Four billion years of life on one planet. That streak might be ours to break, or ours to waste.
Full conversation on Mars, consciousness, and the cosmos over on State Change's YouTube.
Engineering humanity's next generation isn't just science, it's a bet on what balance means for our species
Full breakdown of the tradeoffs on State Change's YouTube channel now
Death isn't just a human problem anymore, it's a family problem
Tomorrow Bio didn't set out to cryopreserve pets, their customers demanded it. Full explanation on State Change's YouTube channel
The next frontier isn't a device in your pocket, it's an interface in your mind
Full conversation on identity, AI, and human agency out now on State Change's YouTube
It's time we stop stigmatizing science and start applying it to the people who need it most
Full breakdown of why Enhanced Games' founder enhanced himself before ever asking an athlete to — on State Change's YouTube channel now
Every superintelligence needs a kill switch—the question is whether we become the ones who need one.
Santiago Siri on the 2001: A Space Odyssey ending nobody wants for humanity. Full conversation on State Change's YouTube.
We're building the biosphere that lets humanity outgrow one planet
Full breakdown of how Mars agriculture actually works on State Change's YouTube
Decentralization can rewrite software, but it can't rewrite biology's laws of atoms
Full breakdown on State Change's YouTube channel
The real risk isn't job loss, it's an identity crisis for anyone whose worth is tied to their work.
Full breakdown of AI, automation, and human purpose on State Change's YouTube channel now.
Death may not be the end of identity, just a pause in the connections that make you, you.
Full breakdown of how cryopreservation actually works on State Change's YouTube channel.
If humanity 2.0 isn't about flying or running faster, then what is it all about?
Full conversation on State Change's YouTube channel.
Language might not be the barrier we think it is. Meaning could just travel as pure information.
Full conversation on State Change's YouTube, Episode 6.