> organoids in space > the darwinian drive towards human enhancement > calibrating your peptide protocol > maximizing experience per unit time a wide-ranging conversation with @maxmarchione on building AGI for your health. Find it on @JoinStateChange.

The prevailing, mind-altering substance of an era has a downstream impact on culture / civilization. This was the case for alcohol (agricultural rev.), caffeine/nicotine (industrial rev.) and psychedelics (counter-culture). @DillanDiNardo suggests w/ custom mindstates we can build a brighter future.

Happen to be in Barcelona 🇪🇸 for a couple days. Can anyone intro me to @THEKER_ai - for a @JoinStateChange interview? Can have a crew and location setup in less than 24 hours.

There's been a lot of chatter about the @enhanced_games following the event last weekend. I had the opportunity to sit down with @max_enhanced himself just prior to the games and here are a few takes that may surprise you. Media Perception vs. Reality The event was labelled the "steroid olympics" in mainstream media, evoking images of needles in dark alleyways and bad incentives. The reality was much different. It's clear that Max and team care deeply about the athletes, which shows in their medical oversight, personalized protocols and (surprise!) their willingness to pay them. Becoming Enhanced was opt-in and some athletes won despite forgoing the drugs at their disposal (more on this later). Ethics & Fairness First, a few choice quotes from anti-doping agencies and the IOC themselves: "If you want to destroy any concept of fair play and fair competition in sport, this would be a good way to do it." "a dangerous clown show that puts profit over principle at the expense of kids across the world thinking they need to dope to chase their dreams." "a Roman circus… sacrificing the lives of people purely for entertainment." On fair play. The playing field was level, it's simply a different field. The most revealing stat, in fact, was that 40% of Olympians admit to doping, they just don't get caught. Worse, they using masking agents to cover the drugs to avoid punitive testing applied prior to the games. Enhanced applies both a uniform ethical standard and incentive structure to optimize for athlete performance, health and compensation. On Winners & Losers Post-game commentary was focused on the fact that not enough world records were broken or non-Enhanced athletes won the day e.g. what does this experiment prove? Sure, this is true. But the commentariat is missing the forest through the trees. I think the biggest win was in the "personal best" category. The fact you can take someone out of retirement and have them beat their 20-year old self. This is a medical marvel and in some ways more impressive than a world record. Additionally, it's pretty clear that if you take an average Joe and enhance him, he's not going to beat Usain Bolt. This was a first time event, that attracted some impressive but not necessarily top .01% athletes. That will change over time. Medical oversight and enhancements will become normalized, or rather, come out of the shadows. We enhance ourselves in nearly every other category (botox, fillers, GLP-1s, adderal etc.). Sport feels like a logical place that's already on the bleeding edge of science and human health. The Games are just a Front End The Enhanced Games was an introduction to the world. But the company is building a much larger strategy. Telemedicine + Biopharma. Discover new enhancements, get FDA approval, work with top-tier human athletes to fine tune protocols, deliver to masses. As @C_Angermayer said, the TAM of vanity is nearly 100%. Hate it or love it, human enhancement is here to stay.

.@alexisthual is such a delight to speak with that completely extraordinary ideas feel almost whimsical. On @JoinStateChange he shared how he's building a frontier LLM of the brain using raw MRI data. The future will be unrecognizable.

This checks out. Had to double check with @b_belvisi this evening— Mars, we’re a go on green! 🌱

Technology moves exponentially, yet our biology evolves over millennia. What happens when we collapse that timeline — and begin rewriting our biological primitives at the pace of software? Human germline editing promises just that: the ability to program the genome, eliminate inherited disease, and redefine the contours of human possibility. In the years ahead, our moral frameworks, scientific institutions, and political systems will strain under questions they were never built to answer. If demography is destiny, are we prepared for a world where an individual’s future may be encoded at conception? The ability to shape future generations forces society to confront a question both thrilling and deeply destabilizing: What does it mean to choose the traits of those who come after us? My @JoinStateChange interview with @CathyTie of @ManhattanGenom drops tonight! Full episode on YouTube!

There is no better symbolism for the decline and ensuing distrust of public financial institutions than an art deco Argentinian bank. It was an immense honor to host @santisiri on @JoinStateChange — a critical voice in democracy and digital governance.

BTS NYC @JoinStateChange

A dialogue with @arthaud_ on how to thoughtfully and securely merge our identities and intellect with the internet. Quite proud to share this first episode with the world. I hope you like it!

To borrow a phrase from @cdixon: Don’t Be Evil ➡️ Can’t Be Evil

Thrilled to be speaking at @unrulyvc's Human Futures Summit. It's basically my thesis defense for @JoinStateChange - hoping to pass with distinction 🎓

I interviewed the founder of a human cryopreservation startup at an abandoned church in the 14th arr. of Paris. My outfit was a subtle nod the priestly fashion so I took a few glamour shots around the set.

🚲 for the 🧠

.@arthaud_ is my go-to on all things internet history. Dark forest, cozy web, network states -- he's my "ideas guy" and spirit guide for this wide-ranging conversation on the future of identity and surfing the agentic web. △▼ Ep 1 Coming Soon △▼