@Jothi_Lab

We make stuff up for living || Chromatin || Transcription || Epigenetics

 Research Triangle Park, North Carolina, …
rajajothi.com
Joined September 2018
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  • Followers142
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Our first animal study! We define a transitional stage between cancer cell dissemination and metastatic outgrowth, providing a framework for investigating biomarkers & therapeutic vulnerabilities during this underexplored phase of metastatic progression. biorxiv.org/content/10.64898…

Malignant epithelial diversification and inflammatory neutrophil remodeling define a transitional...

Most disseminated cancer cells fail to progress to overt metastases, yet the biology that determines whether a disseminated cell remains dormant, dies, or advances toward metastatic outgrowth remains...

biorxiv.org
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We're thrilled to share our collaborative work with @Jothi_Lab on the human embryo atlas for human blastoid assessment (biorxiv.org/content/10.1101/…). This much-needed work by @hani_jieun provides insights into popular human blastoid models.

Systematic evaluation of blastoid models of early human development

Recent generation of stem cell-derived blastoids that recapitulate the architecture and cellular constitution of the human blastocyst offers an experimental model for the elucidation of the biology...

biorxiv.org
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A fascinating close up of how a bee stinger works 📹 Stated Clearly xitter.cf/blabla112345/status/16…
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Confused by all the "what is epigenetics" discourse? Well I have just the thing for you -- presenting the Epigenetics Alignment Chart!
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What role does the bivalent chromatin play in differentiating stem cells? Dr Dhirendra Kumar from @Jothi_Lab will join us next Monday to present his latest research on the regulatory role of bivalency in maintaining epigenetic plasticity. Joins via zoom. No registration required.
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Postdoc positions available in the Jothi Lab at NIH to study transcriptional and epigenetic control of gene expression programs controlling cell fate decisions. Please RT! training.nih.gov/postdoc_job…
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There is a lot of pressure on academics to be extraordinarily successful. Is it worth it? theatlantic.com/family/archi…

‘Success Addicts’ Choose Being Special Over Being Happy

The pursuit of achievement distracts from the deeply ordinary activities and relationships that make life meaningful.

theatlantic.com
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My Department at Thomas Jefferson Univ is hiring a new Assistant Prof. (ad coming soon) in any area of Molecular Biology and Biochemistry! It’s a great Department full of nice people with a lot of collaboration opportunities. DM if you have any question and please RT!
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The Banaszynski lab is hiring a postdoc! We are a chromatin lab studying histone variant biology in the context of both development and disease. Help me spread the word and message me if you are interested. 1/
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Decoding the function of Bivalent Chromatin in development and cancer. Bivalency does NOT poise genes for rapid activation BUT protects promoters from de novo DNA methylation. Bivalent domains have a function after all! tinyurl.com/375t57zr
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New insights on the function of bivalent chromatin. Bivalency does NOT poise genes for rapid activation BUT protects reversibly repressed genes from irreversible silencing. ‘Poised’ RNA Pol II incompatible with transcription; H3K4me3 not instructive disq.us/t/3t9kpqt
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Fun fact 3: Activation of bivalent genes is no more rapid than that of other transcriptionally silent genes, challenging the premise that H3K4me3 is instructive for transcription
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Fun Fact 2: Loss of H3K4me3 at bivalent promoters is strongly associated with aberrant hypermethylation and irreversible silencing in adult human cancers.
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Fun fact 1: H3K4me3 at bivalent gene promoters is a product of the underlying DNA sequence, persists in nearly all cell types irrespective of gene expression, and confers protection from de novo DNA methylation.
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This figure is insane. The extreme underrepresentation of z-values between -2 and 2 (which is just around the commonly used p-value threshold of 0.05) demonstrates publication bias/p-hacking/etc. Sharp edge near the threshold. Source: arxiv.org/abs/2009.09440
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Asymptomatic spread of COVID is not a thing, says study based on Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China disq.us/t/3t05qk0
Postdoc positions available in the Jothi Lab at NIH to study transcriptional and epigenetic control of gene expression. Please RT! training.nih.gov/postdoc_job…
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Spectacular
Doron
@plexaleOK12 Nov 2020
Esto es maravilloso
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We have a 3-yr benchwork (wet lab) research officer position open. This position is jointly mentored by Prof. Patrick Tam and me. For more details: seek.com.au/job/50568775?typ…
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Integrator brings PP2A to Paused Pol For termination #ChromatinHaiku cell.com/molecular-cell/full…
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