@JumpingGenomes

Mitos, plastids, endosymbiosis, gene transfer, origins of life, tRNAs and all things wonky in mol. evolution 🧬 Postdoc in McCutcheon lab. HG fellow @HHMINEWS

 Tempe, AZ
Joined December 2020
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  • Following159
  • Followers211
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Treasure your exceptions, but also your contaminants? The sequencing of “resident” spider mites confirms bizarre mitochondrial tRNA structure (some armless!) but also the novel discovery of transcription of tRNA genes in both directions~Mirrored tRNAs 🧬🪞 academic.oup.com/nargab/arti…

Hopeful monsters: unintended sequencing of famously malformed mite mitochondrial tRNAs reveals...

Abstract. Although tRNA structure is one of the most conserved and recognizable shapes in molecular biology, aberrant tRNAs are frequently found in the mit

academic.oup.com
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Check out our new preprint on plant🌱mitoribosome! We captured it in action, translating mRNA, and combining cryo-EM and Nanopore sequencing, identified key rRNA modifications. Plus we delve into a late-stage maturation step of the small subunit. 📖:biorxiv.org/content/10.1101/…
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Collaborative work of @slavicaPD, @Hashemyaser4, Jovanovic Lab and @DjuranovicLab - a new method to isolate ribosomes and translational material in minutes. We show multiple usage of our RAPPL method in biochemical and structural assays with ribosomes. Please be free to contact us for further instructions if needed. @IsraelF96135088 you'll like this one. A rapid, facile, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies biorxiv.org/content/10.1101/…

A rapid, facile, and economical method for the isolation of ribosomes and translational machinery...

Short abstract Ribosomes are essential RNA-protein complexes involved in protein synthesis and quality control. Traditional methods for ribosome isolation are labor intensive, expensive, and require...

biorxiv.org
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A new fascinating symbiosis in plankton unveiled by imaging and physiology: Hijacking and Integration of Algal Plastids and Mitochondria in a Polar Planktonic Host. New preprint of the team led by @Kedige98 with @dudin_o @e_hehenberger @florianjug groups biorxiv.org/content/10.1101/…
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Who loves pictures of fossils scanned using Laser-Stimulated Fluorescence? (me)
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Check out our paper! We identify a population of retinal progenitors that are maintained late in human retinal development, and give rise to both first- and last-born cell types in the retina, condensing 100 days of retinal development into a small region at the retinal margin!
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Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.1101/…
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Happy to see @ThePlantCell include this text in their author guidelines. I fully agree!
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Excited to see our work out in preprint form! Not all mitochondria carry mtDNA in plants- so we asked: is there a link between dynamics, intermitochondrial connectivity and presence/absence of DNA- and we show- yes! 🤓🌱
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4) The scientific method also applies to computational results: proper controls and negating all alternative hypotheses are just as important in computational biology as in bench experiments.
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My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/
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The mitochondrial protein synthesis machinery in 4D (gorgeous 3D structure plus motion over time) This is how mitochondria synthesize parts of the life-giving electron transport chain
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The Hagler lab is hiring a research technician/assistant!!! Please consider applying if you are interested in RNA structure, RNA-protein interactions, and drug discovery. tamus.wd1.myworkdayjobs.com/…
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No one is left brained or right brained. No one is an introvert or an extrovert, you are not a empath, Gary Chapman is wrong you don’t have one of 5 love language:, Myers Briggs is a hack there are no 16 personalities. Every generation we find a way to reinvent Zodiac signs
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Can free-living eukaryotes exist without mitochondria? In a new paper from my group led by @retortacarp, we show that the answer is probably yes! nature.com/articles/s41467-0…

Extreme mitochondrial reduction in a novel group of free-living metamonads

Nature Communications - Mitochondria are essential cellular components that are found in animals, plants, fungi, and protists. This study reports what is believed to be the first example of...

nature.com
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Replying to @andrewjroger @ania_karnkowska
But M. exilis is a protist that is a commensalistic inhabitant of the gut of chinchillas. In this new paper we find a second case of complete mitochondrial loss in Skoliomonas litria, a protist isolated from alkaline lake sediments by Yana Eglit @PsiWavefunction !
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Happy to share our new preprint, reviewing the expansion of the MutS gene family in plants. Feedback welcome! biorxiv.org/content/10.1101/…
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The move from a free-living environment to an endosymbiotic relationship has profound effects on bacterial function. This #UnsolvedMystery from John P McCutcheon &co explores how bacterial endosymbionts work with so few genes. #symbiosis plos.io/441F6Gk
A phylogenetic tree of bacteria, with major groups containing organisms with genomes of less than 1 Mb noted in blue, and groups with organisms containing genomes less than 200 kb shown in red.

ALT A phylogenetic tree of bacteria, with major groups containing organisms with genomes of less than 1 Mb noted in blue, and groups with organisms containing genomes less than 200 kb shown in red.

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Very happy and proud to share our preprint on biorxiv where we describe two distinct mechanisms of nuclear and mitochondrial transfer RNA 3’ maturation. Thread below.
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Our great work led by the Schumer lab is finally out @Nature This is some of the best evidence out there that mitonuclear interactions can lead to speciation. Article: doi.org/10.1038/s41586-023-0… Summary: tinyurl.com/hamu6n6n

A lethal mitonuclear incompatibility in complex I of natural hybrids

Nature - Analysis of naturally hybridizing swordtail fish species reveals a mitonuclear genetic incompatibility among three genes that encode components of mitochondrial respiratory complex I,...

nature.com
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How is the intricate 3D structure of #tRNA recognized by friend & foe from birth till death? Happy to share my new review @CellChemBiol on the ever-expanding tRNA interactome and diverse mechanisms of #RNA recognition. Read here tinyurl.com/4h9bpkh5 & doi.org/10.1016/j.chembiol.2…
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