🏳️🌈🏳️⚧️
Proxima Centauri b
Joined June 2023
- Tweets12.9K
- Following160
- Followers75
- Likes16.4K
K🏳️🌈🏳️⚧️ retweeted
Today, in collaboration with Anthropic, we’re excited to share rapid initial progress towards an antibody treatment for food allergy, which affects over 200 million people worldwide, discovered with the help of Claude.
At Divergence Labs, we believe that AI can unlock the next generation of antibody therapeutics with more effective mechanisms than before. Such mechanisms are urgently needed in food allergy, which involve overcoming one of the tightest affinity protein pairs in immunology, IgE and its receptor FcεRI, on mast cells.
Treatment with Xolair—the only approved antibody for food allergy—sequesters circulating IgE, but mast cells remain sensitized for weeks to months due to the extraordinarily slow dissociation of IgE from FcεRI.
We envision a treatment that actively pulls IgE off of FcεRI, without waiting for natural dissociation. Like picking a lock, this requires the right combination of geometry and force.
Our research team, working with Claude, ideated on mechanisms to accomplish this disruption, and converged on an antibody format with two arms with different functions and epitopes. Within one month, we designed, synthesized, and experimentally confirmed the biophysical function of the two arms, which we are now assembling into full therapeutic formats.
K🏳️🌈🏳️⚧️ retweeted
Anthropic has filed an S-1 registration statement with the SEC related to its proposed IPO.
Read more: anthropic.com/news/s1-sec
Legal disclaimer: A registration statement relating to these securities has been filed with the SEC but has not yet become effective. These securities may not be sold, nor may offers to buy be accepted, prior to the time the registration statement becomes effective. This post does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.
K🏳️🌈🏳️⚧️ retweeted
Bioware has been a massive part of CDPR history. We befriended them when localizing and selling Baldur’s Gate games in Poland, Czech, and Slovakia. And later they were great help when lending us their engine for Witcher 1, sharing their wisdom and even giving us a spot at their booth at E3. I had a pleasure to visit them a few times in Edmonton and also host them in our Warsaw office. Very sad for the people affected, but also sad to see a legendary brand go down. Not a great day in the games industry.
Na ja keine 10% von Nvidia
400 Milliarden Euro – jetzt liegt die Gesamtrechnung für die deutsche Migrationspolitik vor to.welt.de/ji2ZJCi
K🏳️🌈🏳️⚧️ retweeted
Bruh im in no hate to any gender we need each other but this is hilarious ngl😭😭😭
K🏳️🌈🏳️⚧️ retweeted
La vida útil de los modelos GPT cada vez es más corta:
GPT-1: vivió 248 días
GPT-2: vivió 469 días
GPT-3: vivió 916 días
GPT-3.5: vivió 104 días
GPT-4: vivió 237 días
GPT-4 Turbo: vivió 189 días
GPT-4o: vivió 290 días
GPT-4.5: vivió 46 días
GPT-4.1: vivió 115 días
GPT-5: vivió 97 días
GPT-5.1: vivió 29 días
GPT-5.2: vivió 84 días
GPT-5.4: vivió 49 días
GPT-5.5: vivió 77 días
GPT-5.6: vivió 56 días
GPT-6 Astra: vivió 19 días
GPT-6 Sol: vivió 7 días
GPT-6.1 Sol: acaba de nacer hace 7 días
Antes un modelo duraba años.
Luego meses.
Ahora semanas.
Qué locura.
Bin ehrlich gesagt überrascht.
Man merkt den Unterschied stärkerer Modelle deutlich.
Erst Recht wenn man sie länger laufen lassen kann.
98% of US households aren't paying for AI yet
More charts in State of Markets II: a16z.news/p/state-of-markets…
K🏳️🌈🏳️⚧️ retweeted
Basierend auf deinen Tweets: Die Welt wäre ein ewiger Kölner Karneval mit Kölsch-Flüssen, FC-Kölle- und Pokémon-Tempeln überall. Regenbogen- und Transflaggen wehen global, Gender frei wählbar, UBI für alle, keine Todesstrafe, offene Sexualität und science-basierte Politik. Bunt, locker und queer!
K🏳️🌈🏳️⚧️ retweeted
>be regular office worker in Germany
>Sachbearbeiter, 12 years same company
>48,000€ brutto
>2,590€ netto
>employer also paid ~10,000€ you never see
>"Arbeitgeberanteil"
>rent 1,180€ warm for 58m²
>Nebenkostenabrechnung: +640€ Nachzahlung
>Rundfunkbeitrag for a TV you don't own
>Deutschlandticket was 49€, now 63€
>train cancelled anyway
>get 3% raise
>kalte Progression eats half
>inflation eats the rest
>Tagesgeld 1.75%
>"at least it's safe"
>Renteninformation says 1,410€ at 67
>before tax, before Krankenkasse, before 25 years of inflation
>ask bank advisor about retirement
>he sells you a Riester-Vertrag with 2% annual fees
>Döner now 9.50€
>remember when it was 3.50€
>politician on TV: "we all have to tighten our belts"
>his salary is automatically indexed
>mention Bitcoin at Familienfeier
>uncle: "das ist doch nur für Kriminelle"
>uncle has had 40,000€ on a Sparbuch since 2008
>Wohlstand für Alle
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