@kochinstitute

The Koch Institute brings interdisciplinary approaches together to advance the fight against cancer. More places to follow us: https://xitter.cf/t.co/fPPRkN0PSj

 Cambridge, MA
ki.mit.edu
Joined December 2008
  • Tweets7.7K
  • Following1K
  • Followers45.9K
1.9KMedia
Michael Cima and Karen Daniels smiling - Karen is holding a pretzel-shaped device.

ALT Michael Cima and Karen Daniels smiling - Karen is holding a pretzel-shaped device.

Photo of Michael Cima and Karen Daniel in front of a colorful scientific image in the Koch Institute Lobby.

ALT Photo of Michael Cima and Karen Daniel in front of a colorful scientific image in the Koch Institute Lobby.

Close-up of a woman's hand holding a pretzel-shaped device next to a quarter for size comparison.

ALT Close-up of a woman's hand holding a pretzel-shaped device next to a quarter for size comparison.

Photo of Matthew Vander Heiden, Michael Cima, and Karen Daniels.

ALT Photo of Matthew Vander Heiden, Michael Cima, and Karen Daniels.

2
2
1
9
2,247
A development that could help ensure people are taking their medication on schedule, MIT engineers have designed a pill that can report when it has been swallowed. Giovanni Traverso says. news.mit.edu/2026/pills-comm…

Pills that communicate from the stomach could improve medication adherence

MIT engineers designed a pill that can report when it has been swallowed, an advance that could aid in medication adherence.

news.mit.edu
5
25
4
79
8,005
Nanoparticles coated with molecular sensors could be used to develop at-home tests for many types of cancer. news.mit.edu/2026/ai-generat…

AI-generated sensors open new paths for early cancer detection

A new AI model designs peptides (short proteins) that are targeted by enzymes called proteases, which are overactive in cancer cells. Nanoparticles coated with these peptides can act as sensors that...

news.mit.edu
10
31
2
115
8,423
Research from Patrick Doyle's team offers a new way to deliver antibodies packaged into microparticles that could be injected with a syringe. This could offer patients an alternative to lengthy & uncomfortable infusions: mit-ki.org/4aHnV27
A syringe full of microparticles

ALT A syringe full of microparticles

4
3
2
10
1,033
Koch Institute at MIT retweeted
MIT.nano@mit_nanoJan 6
Detecting cancer in the earliest stages could dramatically reduce cancer deaths. To help achieve that goal, @MIT & @Microsoft researchers are using artificial intelligence to design molecular sensors for early detection. @MIT_IMES @kochinstitute @MITEECS news.mit.edu/2026/ai-generat…

AI-generated sensors open new paths for early cancer detection

A new AI model designs peptides (short proteins) that are targeted by enzymes called proteases, which are overactive in cancer cells. Nanoparticles coated with these peptides can act as sensors that...

news.mit.edu
2
8
1
13
1,078
Replying to @Cancer_dynamics @TeresaDavoli3 @nyulangone @khanh_n_dinh @nyugrossman @CancerGrand @columbiacancer @Columbia_Bio @kchenken @MDAndersonNews @RiceCompSci @ColumbiaCompSci @SRsrivatsan @fredhutch @HutchBasicSci @joselmcfaline @ColumbiaBME
On January 14 at 2 pm, we welcome @MattG_Jones from @MITBiology and @kochinstitute who will discuss about the quantitative profiling of tumor evolution beyond chromosomes. Register here: cancerdynamics.columbia.edu/…
flyer fro January seminar

ALT flyer fro January seminar

2
3
1
6
1,475
A new “dual warhead” therapy from the Hemann, Yilmaz & Lippard labs preserves anthracycline potency while sidestepping efflux pump–driven resistance. The Nature Communications study shows extended survival in metastatic colon cancer models. nature.com/articles/s41467-0…
Scientific figure - Key challenges associated with combination therapies using conventional ATP-binding cassette (ABC) transporter inhibitors to overcome multidrug resistance mediated by P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and ATP-binding cassette super-family G member 2 (ABCG2). b Platinum-containing drug conjugates exploit platinum-protein interactions to overcome efflux pump-mediated multidrug resistance without disrupting normal efflux activity. c Synthesis of the doxorubicin-oxaliplatin conjugate, doxaliplatin (DoxPt, 2), with minimal structural modifications to both parental drugs. d Doxaliplatin derivatives with different structural features.

ALT Scientific figure - Key challenges associated with combination therapies using conventional ATP-binding cassette (ABC) transporter inhibitors to overcome multidrug resistance mediated by P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and ATP-binding cassette super-family G member 2 (ABCG2). b Platinum-containing drug conjugates exploit platinum-protein interactions to overcome efflux pump-mediated multidrug resistance without disrupting normal efflux activity. c Synthesis of the doxorubicin-oxaliplatin conjugate, doxaliplatin (DoxPt, 2), with minimal structural modifications to both parental drugs. d Doxaliplatin derivatives with different structural features.

11
1
53
3,464
Can we demystify endometriosis? On NPR’s Science Fridays (@scifri), Linda Griffith highlights challenges in endometriosis—from ‘squeamishness’ around conversations to difficulties in clinical diagnosis—& promising innovations in modeling & treatment. mit-ki.org/4pRloXq
Photo of Linda Griffith, wearing a black blazer, in her laboratory.

ALT Photo of Linda Griffith, wearing a black blazer, in her laboratory.

1
5
952
Happy New Year from the Koch Institute! Wishing our community a year filled with discovery, collaboration, and progress.
Text that says Happy New Year set against a navy blue background with fireworks and featuring five squares featuring colorful scientific images. A logo with white text reading Koch Institute for Integrative Cancer Research appears in the lower left corner.

ALT Text that says Happy New Year set against a navy blue background with fireworks and featuring five squares featuring colorful scientific images. A logo with white text reading Koch Institute for Integrative Cancer Research appears in the lower left corner.

12
690
MIT Technology Review (@techreview) shines a spotlight on the cutting-edge work taking place in Giovanni Traverso’s lab. From ingestible biosensor pills to capsules that can replace insulin shots, Traverso is focused on improving patients’ lives.   mit-ki.org/3KOLL1u
Photo of Giovanni Traverso wearing a blue shirt and blue pants sitting in his lab.

ALT Photo of Giovanni Traverso wearing a blue shirt and blue pants sitting in his lab.

9
1,093
A new @NatureMaterials study from the Hammond and former Irvine labs shows IL-12 nanoparticles paired w/ checkpoint inhibitors eliminated metastatic ovarian tumors in >80% of mice and formed lasting immune memory. Story: news.mit.edu/2025/new-nanopa…
A nanoparticle designed to deliver immune-stimulating molecules to ovarian cancer cells, depicted as two blue circles with red and white string-like edges.

ALT A nanoparticle designed to deliver immune-stimulating molecules to ovarian cancer cells, depicted as two blue circles with red and white string-like edges.

4
1,147
Mini Brains, Major Insights: Robert Langer & Li-Huei Tsai developed “miBrains,” 3D human brain tissue models for disease research and drug testing. Scalable, customizable, and made from donors’ iPSCs, they integrate all major brain cell types. Read more: bit.ly/3rM7iBrains
3x2 grid of circles composed of hundreds of cyan-stained cells on a black background. Circles are labled: pericytes, astrocytes, endothelial cells, neurons, ogliodendroglia, and microglia

ALT 3x2 grid of circles composed of hundreds of cyan-stained cells on a black background. Circles are labled: pericytes, astrocytes, endothelial cells, neurons, ogliodendroglia, and microglia

8
22
1,964
Koch Institute at MIT retweeted
Constantine Tzouanas@constantine_sci22 Dec 2025
Out today in @CellCellPress! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)
5
99
2
423
34,489
Elicio Therapeutics’ Phase 2 trial of its KRAS-targeted cancer vaccine shows promising results: 99% of evaluable pancreatic cancer patients mounted an immune response and 88% responded to their own tumor-specific mutation. investing.com/news/company-n…
image of cells, depicted as a blob with swirls of green, blue and purple

ALT image of cells, depicted as a blob with swirls of green, blue and purple

4
1
10
1,037
As 2025 comes to a close, we’re highlighting some of the year’s standout KI research—from ovarian immunotherapy and CAR-NK cells to antibody-guided chemo, AI-designed nanoparticles, and cancer cell dormancy. More on our website: ki.mit.edu/news/2025/the-koc…
Red, green and yellow circles with a black rectangle with a red border in the center and the text "The Koch Institute's Top Research Stories of 2025"

ALT Red, green and yellow circles with a black rectangle with a red border in the center and the text "The Koch Institute's Top Research Stories of 2025"

1
1
584
Koch Institute at MIT retweeted
Deblina Sarkar
@DeblinaSarkar5918 Dec 2025
Thrilled to share the #BBC documentary featuring our technology, #Circulatronics — a new paradigm of #Autonomous, #SurgeryFree #BCI. In “Chris McCausland: Seeing into the Future,” Chris McCausland—an English comedian and actor who lost his eyesight in his early twenties—explores how emerging technologies can profoundly transform human life. The documentary highlights Circulatronics: tiny, sub-cellular-scale, wireless electronics—billion times smaller than a grain of rice—designed to circulate through body fluids, autonomously recognize diseased brain regions, cross blood-brain-barrier and self-implant, eliminating the need for invasive surgery. In this episode, we discuss how Circulatronics could enable: restoration of vision, treatment of devastating neurological diseases, new approaches for terminal brain cancers, and a future where humans could transcend beyond biological limitations! . 🧠 Excerpt of the BBC video: youtube.com/watch?v=GOygvrPW… 🎬 Full video at BBC iplayer: bbc.co.uk/iplayer/episode/m0… 🎥 MIT Video: youtube.com/watch?v=dDcgLM6G… 📖 MIT news release: news.mit.edu/2025/new-therap… . . . @MIT @medialab @kochinstitute @mit_nano @mcgovernmit @mitsap #MedTech #Nanoelectronics #Neurotechnology #BCI #DBS #BrainImplant
1
9
1
62
3,895
Koch Institute at MIT retweeted
Neural Cell News
@NeuralCell18 Dec 2025
A team at the @KochInstitute performed cell type–specific immunopeptidome analysis on primary #macrophages and #glioblastoma tumor cells in a coculture system to profile MHC-I–associated antigen presentation at the tumor–macrophage interface. 🔖 @AACR: bit.ly/4oW64YZ
1
1
490
Thank you to Anna Uzonyi (@WeizmannScience) & Lukas Henneberg (@‌MPI_Biochem), the 2024 Amon Award winners, for sharing their groundbreaking research with us. And thanks to our emcees Monica Boselli and Xiaofeng (Allen) Su and Amon Lab alums for your support!
A group of six people posing for a photo

ALT A group of six people posing for a photo

2
4
772
Koch Institute at MIT retweeted
Nature Biotechnology
@NatureBiotech16 Dec 2025
Antibody-lectin chimeras for glyco-immune checkpoint blockade go.nature.com/4aRDpk8
2
35
3
150
19,432
Koch Institute at MIT retweeted
McGovern Institute
@mcgovernmit12 Dec 2025
From nematode to Nobel: How an unassuming roundworm has illuminated aspects of biology with major consequences for human health. mcgovern.mit.edu/2025/12/12/… @MITBiology @kochinstitute @ScienceMIT @MIT_Picower @hhmi_science @PNASNews

Celebrating worm science - MIT McGovern Institute

For decades, scientists with big questions about biology have found answers in a tiny worm. That worm–a millimeter-long creature called Caenorhabditis elegans–has helped researchers uncover fundame...

mcgovern.mit.edu
1
5
7
1,254
Load more