The aim of Lab. Molecular & Cellular Signaling is to explore and exploit Ca2+ signaling in apoptosis and autophagy in health and disease. Views are my own.
K.U. Leuven, Belgium
Joined January 2011
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Geert Bultynck 🇺🇦 retweeted
Radiocommentaar van @tomboudeweel met beeld, pure passie.
Geert Bultynck 🇺🇦 retweeted
Today @KarlDeisseroth of @StanfordMed @Stanford won the @NobelPrize for his co-discovery & development of Optogenetics. Here he explains what that is, and how it is unlocking the secrets of brain function & helping to cure diseases.
(And he explains that in ~1min).
Geert Bultynck 🇺🇦 retweeted
Today, the MitoCarta Tree of Life Consortium (MitoTOL) is releasing high-accuracy mitochondrial proteomes across diverse eukaryotes to empower studies of physiology, evolution, and disease:
cell.com/consortium/mitocart…
All data can be accessed at:
mitocarta.org
Geert Bultynck 🇺🇦 retweeted
How do plants turn local wounding response into a whole-plant defense?
Our work identifies CNGC13, a vasculature localized Ca²⁺ channel that helps propagate systemic Ca²⁺ waves and activate jasmonate & glucosinolate defenses in Arabidopsis.
A new piece of the puzzle in long-distance plant immunity and wound signalling and acts in parallel to well known GLR channels
First PNAS from my lab and is combined efforts of a great team : Misha @MishaKu16647918 and Ramgopal as first authors. Supported by Bhawana @BhawanaSha17 and Mahendra @MahiPawar12 from lab
We thank Alex Costa @lab_costa for his constant support and collaboration ; Yong-Fei Wang for electrophysiology
A huge shout out to @DBTIndia @NIPGRsocial for funding and encouraging basic plant science in India and Arabidopsis research
pnas.org/doi/10.1073/pnas.26…
Geert Bultynck 🇺🇦 retweeted
Farrell, Ryan @weillcornell and colleagues characterize a new ratiometric ER calcium indicator that uses HaloTag to normalize for reporter expression. The approach allows comparisons of ER Ca2+ concentration across cell types and subcellular regions. hubs.la/Q04tydMx0
Geert Bultynck 🇺🇦 retweeted
Excited to see our work now published science.org/doi/10.1126/scie…!
Lysosomal dysfunction has long been considered a hallmark of aging, but we still know remarkably little about what actually changes inside lysosomes as organisms grow old. Using rapid lysosome isolation and metabolomics, we built the first atlas of lysosomal aging across tissues.
Geert Bultynck 🇺🇦 retweeted
Half of all rare-disease patients are children, and more than 30% do not reach their fifth birthday
go.nature.com/4yRw79S
Our collaborative study on mechanisms of venetoclax resistance is now published in #Advanced #Science journal as an Early View from Advanced Portfolio. Please check LinkedIn for a more detailed explanation and gratitude to all contributors & collaborators. advanced.onlinelibrary.wiley…
royalsocietypublishing.org/r…
Using IP3R KO cells expressing single IP3R isoforms, we show that anti-apoptotic BCL-2 proteins bind to and inhibit channel opening, Ca2+ signals & ER-mitochondrial Ca2+ transfers mediated by all three IP3R isoforms. So, BCL-2 is a general IP3R modulator!
Excellent work published in Open Biology by Ian de Ridder, Claire Cauwelier and @JensLoncke from @LMCSLeuven together with fantastic collaborators: @vikas_arige and Larry Wagener from @DavidYule64 team for expertise in e-phys/Ca2+-puffs & @Irina52948708 for structural insights!
Geert Bultynck 🇺🇦 retweeted
New from our lab: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity
It resolves in organelles e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
Geert Bultynck 🇺🇦 retweeted
New "Cardiometabolic Clock" identifies biomarkers that associate with disease & early death:
1. HbA1c
2. Creatinine
3. Lymphocyte %
4. Urea nitrogen (BUN)
5. Red Cell Dist. width (RDW)
6. Pulse
7. Systolic blood pressure
Now you can calculate your CardioMetAge!
Geert Bultynck 🇺🇦 retweeted
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites | bioRxiv biorxiv.org/content/10.64898…
Geert Bultynck 🇺🇦 retweeted
Registration is now OPEN for the EMBO Workshop on Plant Calcium Signaling 2026!
Dive into cutting-edge research on Ca²⁺ signaling in plants 🌿
📍 Primosten, Croatia | 🗓️ 20–24 September 2026
meetings.embo.org/event/26-c…
@charpentier_lab
Geert Bultynck 🇺🇦 retweeted
Thank you for highlighting our work with very visionary perspectives! @MassimilianoS16 @NatureCellBio
Decoding the proton veil around lysosomes
nature.com/articles/s41556-0…
We truly hope this work will open up a new concept on "organelle microenvironment" ☺️😍😊
