@LabFame

basic & translational research • brain development • CSF-based signaling & choroid plexus • @StanfordMed • Dept. of Neurosurgery @StanfordNsurg • @ScienceDame

 Stanford School of Medicine
famelab.stanford.edu/
Joined July 2022
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  • Following159
  • Followers432
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The Fame Lab was thrilled to attend this Symposium with co-organized by Ryann @ScienceDame and Kalanit Grill Spector @kalatwt about the New Frontiers of Developmental Neuroscience! What fantastic speakers and new ideas!
Wu Tsai Neurosciences Institute@StanfordBrainOct 15
Our 13th Annual Stanford Neurosciences Symposium has begun! Our topic: Building the Brain. We’re exploring how our brains wire themselves up from a few cells into the three pounds of matter in our skulls that makes us who we are.
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Congratulations to Sarah on passing her qualifying exam! A new PhD candidate is minted!
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So grateful for everyone who has supported me on this journey. Special thanks to all my current and former trainees!
Stanford Neurosurgery@StanfordNsurgJan 9
Congratulations to Julia Kaltschmidt, PhD (@kaltschmidt_lab), on her promotion to Professor of Neurosurgery! Dr. Kaltschmidt!
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Congratulations to Julia Kaltschmidt, PhD (@kaltschmidt_lab), on her promotion to Professor of Neurosurgery! Dr. Kaltschmidt!
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📃Preprint alert @biorxivpreprint . Does your 2026 involve ICV injections of AAVs 🧠? If so, this study led by Luke in the lab is for you. biorxiv.org/content/10.64898…
Representative 3D reconstructions of brain ventricles from control and high-dose AAV2/5-injected pups at 2, 5, and 7 days post-injection (P2.5, P5.5, P7.5). Quantification of total ventricular volume across time points. (n = 3 per condition)

ALT Representative 3D reconstructions of brain ventricles from control and high-dose AAV2/5-injected pups at 2, 5, and 7 days post-injection (P2.5, P5.5, P7.5). Quantification of total ventricular volume across time points. (n = 3 per condition)

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Dose is key🗝️. Higher doses of AAV (1uL of 4 x 10^12 GC/mL) consistently induced ventriculomegaly and permissive tropism in neonates, while moderate doses (1uL of 1 x 10^12 GC/mL) didn't. Study led by Luke Liu, with co-authors Ania Noguera, Ryan Humphries, and Blake Zhou.
Representative coronal sections at the level of the posterior anterior commissure (pAC; dashed outline) showing lateral ventricle morphology in P7.5 brains following P0.5 ICV injections.

ALT Representative coronal sections at the level of the posterior anterior commissure (pAC; dashed outline) showing lateral ventricle morphology in P7.5 brains following P0.5 ICV injections.

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Such a joy to celebrate with this group! Happy holidays from our lab to yours! 🧠☃️🥼🧪
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Go with the Flow🧠💦 at #SfN25. Meet the speakers of Nano 040 today (Tuesday 11/18) at 1pm in room 24A. #NeuroTwitter #SciTwitter @SfNtweets
Nano 040 today (Tuesday 11/18) at 1pm in room 24A. Neil Dani, Vanderbilt Laura Pellegrini, KCL Huixin Xu, BCH Luke Liu, Stanford Cameron Sadegh, UC Davis Ed Monuki, UC Irvine Haley Masters, Vanderbilt Catie Profaci, Scripps Agnes Luo, U of Cincinnati Deidre Jansson, U of Washington Ryann Fame, Stanford

ALT Nano 040 today (Tuesday 11/18) at 1pm in room 24A. Neil Dani, Vanderbilt Laura Pellegrini, KCL Huixin Xu, BCH Luke Liu, Stanford Cameron Sadegh, UC Davis Ed Monuki, UC Irvine Haley Masters, Vanderbilt Catie Profaci, Scripps Agnes Luo, U of Cincinnati Deidre Jansson, U of Washington Ryann Fame, Stanford

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Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models - @StanfordRad go.nature.com/4nO5s71
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“We’re making a helmet people can wear that delivers ultrasound to the brain, and we plan to initiate clinical testing of this protocol in the next few months,” said Raag Airan. With Knight Initiative support, his lab plans to test it on people soon. 🔗brainresilience.stanford.edu…
Raag Airan, Matine Azadian, Payton Martinez and Yun Xiang in the lab. Azadian is holding a version of their ultrasound apparatus designed for humans.

ALT Raag Airan, Matine Azadian, Payton Martinez and Yun Xiang in the lab. Azadian is holding a version of their ultrasound apparatus designed for humans.

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Will you be at @SfNtweets #SfN25? Yes? Us too! Come see the Fame lab!
Blake Zhou Sunday, 11/16, 8am-12pm. Presentation Number: PSTR053.24/ A22 Location/Room: A22 SDCC Halls B-H Arjun Rajan Sunday, 11/16, 1pm-5pm. Presentation Number: PSTR102.04/A40 Location/Room: A40 SDCC Halls B-H Luke Liu + Ryann Fame Tuesday 11/18, 1pm-3:45pm. Session Number: Nanosymposium NANO040 Session Title: Choroid Plexus and CSF Biology Location/Room: SDCC Rm 24A Nano040.04; Nano040

ALT Blake Zhou Sunday, 11/16, 8am-12pm. Presentation Number: PSTR053.24/ A22 Location/Room: A22 SDCC Halls B-H Arjun Rajan Sunday, 11/16, 1pm-5pm. Presentation Number: PSTR102.04/A40 Location/Room: A40 SDCC Halls B-H Luke Liu + Ryann Fame Tuesday 11/18, 1pm-3:45pm. Session Number: Nanosymposium NANO040 Session Title: Choroid Plexus and CSF Biology Location/Room: SDCC Rm 24A Nano040.04; Nano040

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The Fame Lab is 3 years old this week! Time flies with this fantastic group of scientists!
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We are thrilled to receive support from the @StanfordBrain Wu Tsai Institute to start a new collaboration with @HeilshornSarah and her team!
Wu Tsai Neurosciences Institute@StanfordBrain2 Oct 2025
Congrats to the Seed Grant awardees! Projects include efforts to develop new tools for delivering drugs to the brain; study the role of neuropeptide molecules in pain & brain signaling; and probe the links between genetics, inflammation, & Alzheimer’s. 🔗neuroscience.stanford.edu/ne…
2025 Seed Grant awardees (10 awardees across 5 projects)

ALT 2025 Seed Grant awardees (10 awardees across 5 projects)

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Third Annual Dish Dish Dish to enjoy each other's company and celebrate a love of science! 📡 🗣️ 🍽️ @StanfordNsurg #ScienceMatters
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Today, we celebrate Ania Noguera's time in the lab. On her last day with us, we are so excited about her transition to @UCBerkeley - but will miss her expertise here! 🧠
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Our July issue is now live! nature.com/neuro/volumes/28/…
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Stepping out of the lab to enjoy some artistic pursuits!
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Molecular Hallmarks of Hydrocephalus @ScienceTM is out today. Grateful to work under leadership of @andrewthale3 @ScienceDame @KahleKristopher with other top-notch collaborators including @LabFame members Arjun Rajan and Blake Zhou! science.org/doi/10.1126/scit…
https://www.science.org/doi/10.1126/scitranslmed.adq1810

ALT https://www.science.org/doi/10.1126/scitranslmed.adq1810

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How does the brain change during the day🌞🌛? Can this inform treatments? Learn more in a new review from the lab 'Harnessing the #circadian nature of the choroid plexus and cerebrospinal fluid' npj Biological Timing & Sleep | #Nature @Nature_NPJ nature.com/articles/s44323-0…
Fig. 1 | Components of the cerebrospinal fluid (CSF) system change across timeof day. A The major components of the CSF system include CSF, choroid plexus, andcircumventricular organs. These systems change their properties across time of day,including those listed below each component. B Multiple inputs affect the CSFsystem across time of day.

ALT Fig. 1 | Components of the cerebrospinal fluid (CSF) system change across timeof day. A The major components of the CSF system include CSF, choroid plexus, andcircumventricular organs. These systems change their properties across time of day,including those listed below each component. B Multiple inputs affect the CSFsystem across time of day.

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Many thanks to the editors of @Nature_NPJ Biological Timing and Sleep for treating this important topic and for the collegial and scholarly reviewers who reviewed this article. rdcu.be/enKEO
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