Research lab at #unmc #NebraskaMed. We study fundamental principles that govern #blood homeostasis and response to stress in #anemia and #AML.
Omaha
Joined July 2019
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Kyle Hewitt retweeted
Every so often, a major event happens in your life to validate years of work. SRRK’s ISEMBYLD was FDA approved. Having participated in its development from basic science to approval, as a physician-scientist, this is one of my best days. Happy for ISEMBYLD to help SMA patients.
Kyle Hewitt retweeted
Here are 30 great essays about biology. I consider these to be my "personal canon," and think that they are all basically perfect in their own ways, despite being different in form and style. All have shaped my own writing considerably.
I'm not including links here, but you can easily search and find these.
1. Diagnosing the decline in pharmaceutical R&D efficiency, Jack W. Scannell et al., 2012
2. Predictive validity in drug discovery: what it is, why it matters and how to improve it, Jack Scannell et al., 2022
3. Is the cell really a machine?, Daniel J. Nicholson, 2019
4. How academia and publishing are destroying scientific innovation: a conversation with Sydney Brenner, Elizabeth Dzeng, 2014
5. A Future History of Biomedical Progress, Adam Green (Markov), 2022
6. The pharma industry from Paul Janssen to today, Alex Telford, 2023
7. The Lives of a Cell, Lewis Thomas, 1974
8. The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades, Sharon Begley, 2019
9. The Scientific Virtues, Slime Mold Time Mold, 2022
10. First Clean Water, Now Clean Air, Fin Moorhouse, 2023
11. I should have loved biology, James Somers, 2020
12. The Baffling Intelligence of a Single Cell, James Somers & Edwin Morris, 2024
13. Biology is more theoretical than physics, Jeremy Gunawardena, 2013
14. Can a biologist fix a radio?, Yuri Lazebnik, 2002
15. Cells are very fast and crowded places, Ken Shirriff, 2011
16. Life at Low Reynolds Number, E.M. Purcell, 1976
17. Lena, qntm, 2021
18. Sequences and Consequences, Sydney Brenner, 2010
19. The NIH Report, Matt Faherty, 2022 (I edited this one)
20. Simplicity in biology, Uri Alon, 2007
21. A breakthrough from 60 years ago: “General nature of the genetic code for proteins” (1961), Matthew Cobb, 2021
22. Molecular “Vitalism”, Marc Kirschner, John Gerhart, Tim Mitchison, 2000
23. The Coming Technological Singularity, Vernor Vinge, 1993
24. Review of Scientific Self-Experimentation, Brian Hanley & William Bains & George Church, 2018
25. Coming full circle-from endless complexity to simplicity and back again, Robert Weinberg, 2014
26. Nothing in Biology Makes Sense Except in the Light of Evolution, Theodosius Dobzhansky, 1973
27. The Impersonator: The Fake Data Were Coming From Inside the Lab, Uri Simonsohn, 2024
28. The Longevity FAQ, José Luis Ricón (Nintil), 2020
29. The Perfect Human is Puerto Rican, Lior Pachter, 2014
30. No Evidence of Disease, Stephanie Bourque, 2012
Kyle Hewitt retweeted
1/ Excited to share CellFlow, a new approach for complex perturbation modeling in single-cell genomics based on flow matching. From cytokine screens to cell fate and organoid engineering, we show CellFlow’s broad power across many diverse tasks.
👉 Paper: biorxiv.org/content/10.1101/…
This seems like a fundamental misunderstanding of the process of grant review, probably because the people making decisions just don't know.
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Indirects were due for a substantive reckoning at some point, but indiscriminate and immediate cuts don't make sense.
1) Since there is a lot of confusion about the reduction of the overhead rate on NIH grants to 15% (see here: grants.nih.gov/grants/guide/…) I'll do a little tweetorial (or X-torial?) about it.
Looking forward to hosting @theclotthickens in our GCBA seminar series! 👇
GCBA Seminar Series announces Kellie Machlus PhD, Assistant Professor , Harvard Medical School, Genetics, presenting "Unraveling Roles for Megakaryocytes Beyond Platelet Production Using Novel Model Systems" @Thecloththickens @UNMC_GCBA @UNMC_BISB
3/
3) .... Rahul Dogiparthi presents a poster that describes a novel approach to prioritize and ascribe function to signal-responsive enhancers in the genome. Check it out.
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2) Meg Schaefer presents her poster on a protein called SAMD1 and how it controls histone methylation...
1/ Graduate students in the Hewitt Lab @UNMCCOM are presenting three times at ASH #ASH2024! Come see us:
1) Pooja Roy @PoojaRoy96 is presenting in the oral abstracts session of the 101. She'll talk about her work on Samd14 in stress erythropoiesis
Looking forward to this. 👇
GCBA Seminar Series announces Vijay Sankaran, MD, PhD, Professor, Broad Institute of MIT and Harvard and Boston Children’s Hospital & Harvard Medical School, Department of Pediatrics presenting "Genetic Studies of Human Hematopoiesis" @bloodgenes @UNMC_GCBA @UNMC_BISB
Kyle Hewitt retweeted
We are hiring at the Assistant Professor level at @TuftsUniversity #BME! If you are on the market this year and looking to join a collaborative R1 school with fantastic colleagues and students, give us a look!
#TenureTrack | @TuftsBME | @TuftsEngineer
apply.interfolio.com/153806
It was nice to see my postdoc mentor and former lab mates in the Bresnick lab. Awesome food and company. @ISEHSociety
This was an excellent symposium. Happy to be able to present a collaboration between our group and @RKateHyde using organoids to mimic hematopoiesis in a dish.
Some photos from the final part of today’s Symposium agenda which featured promising research partnerships formed in the Pediatric Cancer Research Group. @AfshinSalehi @MohsLab @aandersonberry @LabHewitt
