@LabJacks

The Jacks Lab, established in 1992. Koch Institute for Integrative Cancer Research at MIT. Cancer genetics. GEMMs. Tumor immunology. Run by lab members.

 Cambridge, MA
jacks-lab.mit.edu/
Joined June 2021
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  • Followers3.3K
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We've moved!
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Replying to @LCdr_mcgarrett
This account is run by ill-informed lab members 😂 inquire with the link!
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Replying to @Aamirsohailkt
This account is run by ill-informed lab members 😂 inquire with the link
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We're hiring technicians! Apply below. careers.peopleclick.com/care…
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Thanks to Tyler and Laura for hosting!
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As the lab gets up and running following the break we'd like to share this picture from the annual holiday party. What a fun time!
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The Lab Christmas tree is officially lit! Happy holidays to all :)
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We were honored to be a part of the annual @lustgartenfdn walk this morning!
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Out today, with @LabJacks, @isidrolauscher, @fran_muyas, we used new mouse models of spontaneous lung and colon cancer to delineate a mechanism for why many patients with DNA mismatch repair deficient (MMRd) tumors may not respond to immunotherapy 🧵1/11 nature.com/articles/s41588-0…

Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity

Nature Genetics - Mouse models of lung and colorectal cancer with sporadic DNA mismatch repair deficiency clarify that the intratumor heterogeneity and clonal architecture rather than tumor...

nature.com
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A heartfelt farewell to our amazing summer students Safya and Michelle! Congratulations on the amazing work and posters!
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Our prime editor mouse is now available to request from The Jackson Laboratory: jax.org/strain/037953 jax.org/strain/037954
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A prime editor mouse to model a broad spectrum of somatic mutations in vivo go.nature.com/3Bk8fz4
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Many thanks to our awesome collaborators: @davidrliu, @fjsanchezrivera, and others!
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Excited to share our new publication in @NatureBiotech nature.com/articles/s41587-0… Here, we introduce a genetically engineered mouse model that enables prime editing in vivo! We're excited about the system's potential for rapid and precise modeling of essentially any cancer mutation!
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Jacks Lab retweeted
EACR@EACRnews10 May 2023
Tyler Jacks’ Keynote Lecture: “Genetic engineering meets tumor immunology: Lessons from mouse models of cancer” @LabJacks #eacrImmunoOncology
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Tyler Jacks from @kochinstitute @MIT presenting eloquent vignettes (called tapas while @EACRnews #eacrImmunoOncology in Spain) on genetic engineering approaches in mice that have revealed profound insights into immuno-oncology and novel targets.
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Ludwig @MIT Co-director Tyler Jacks spoke at #AACR2023 about the use of mouse models of cancer—further engineered to express cancer antigens or accumulate mutations in cancer cells—as a tool for nuanced and comprehensive study of anti-tumor immune responses.
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