@LabSigal

Sigal lab @ChariteBerlin and @BIMSB_MDC. Regeneration, inflammation and carcinogenesis. Organoid lab. Tweets from lab members.

 Berlin, Germany
Joined April 2022
  • Tweets171
  • Following314
  • Followers334
61Media
New paper from the Sigal lab: nature.com/articles/s41467-0…

Extrusion of BMP2+ surface colonocytes promotes stromal remodeling and tissue regeneration

Nature Communications - The mechanisms driving epithelial regeneration in the colon are not well understood. Here, the authors show that IFN-γ, produced by immune cells in response to...

nature.com
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We are very proud to announce that yesterday our PhD Student Kimberly @KimberlyHartl_ successfully defended her thesis. Congratulations Dr Hartl! 🎓 We wish you all the best for your future career 🥳 #AcademicTwitter #PhDone
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Proud to share that our department @ChariteBerlin was awarded Platinum level certification by @My_Green_Lab! Thx to @Flt3Linda & @KimberlyHartl_ for taking the lead! The #GreenLabCertification is the international gold standard in #lab #sustainability best practices!
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For more info see: bit.ly/greenlabcert

My Green Lab Certification: The World’s Most Trusted Green Lab Certification.

Join 4,000+ certified labs committed to sustainable science. Save money, improve efficiency, and drive measurable impact with the global standard for sustainable labs.

mygreenlab.org
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During the last month we had to say goodbye to two wonderful colleagues! @LCLiu17 and @KimberlyHartl_ , we wish you both a brilliant future ahead! #AcademicTwitter
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Menschen mit Colitis ulcerosa haben ein höheres Darmkrebsrisiko. Die Rolle des Gens p53 dabei und wie man Krebsvorläufer möglicherweise früh medikamentös ausschalten könnte, beschreiben Forschende der #CharitéBerlin und des @MDC_Berlin in @ScienceAdvances. charite.de/forschung/paper_s…
Links: Normales Gewebe kehrt nach der Reparatur einer Schädigung in den gesunden Status zurück. Erkennbar sind die von magentafarbenen Epithelzellen ausgekleideten Darmkrypten, nur wenige (grün markierte) Zellen teilen sich. Rechts: Gewebe, dem das P53-Protein fehlt, teilt sich unkontrolliert weiter. © Charité | K. Hartl / M. Sigal

ALT Links: Normales Gewebe kehrt nach der Reparatur einer Schädigung in den gesunden Status zurück. Erkennbar sind die von magentafarbenen Epithelzellen ausgekleideten Darmkrypten, nur wenige (grün markierte) Zellen teilen sich. Rechts: Gewebe, dem das P53-Protein fehlt, teilt sich unkontrolliert weiter. © Charité | K. Hartl / M. Sigal

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We're thrilled to announce our latest study led by @KimberlyHartl_ has now been published in @ScienceAdvances! Together with colleagues at @ChariteBerlin and @BIMSB_MDC we unravel the role of p53 in #UlcerativeColitis! A 🧵- full paper here: science.org/doi/full/10.1126… @MDC_Berlin
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more replies
Those cells also fail to re-establish homeostasis metabolically and show an increased glycolytic flux - and can be targeted by a small-molecule glycolysis inhibitor.
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Our study gives a first explanation how cells that lack p53 signaling could outcompete healthy bystander cells and thus become fixed in the mucosa. They can be targeted metabolically, which could be used for preventive and diagnostic measures.
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During regeneration, when there is a Wnt burst, we see upregulation of p53 in both model systems. P53 acttvation then in turn leads to downregulation of Wnt targets again.
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However, when p53 signaling is lost, injured epithelial fails to return to a healthy, homestatic state and is "locked" in the regenerative, fetal-like state with high YAP signaling.
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Researchers @LabSigal at #mdcBerlin and @ChariteBerlin have elucidated the role of the #p53 gene in #ulcerativecolitis. The study published in @ScienceAdvances suggests a potential new drug target. The research was led by @KimberlyHartl_. Read more: mdc-berlin.de/news/press/can…
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