@LabSigal

Sigal lab @ChariteBerlin and @BIMSB_MDC. Regeneration, inflammation and carcinogenesis. Organoid lab. Tweets from lab members.

 Berlin, Germany
Joined April 2022
  • Tweets171
  • Following314
  • Followers334
61Media
Menschen mit Colitis ulcerosa haben ein höheres Darmkrebsrisiko. Die Rolle des Gens p53 dabei und wie man Krebsvorläufer möglicherweise früh medikamentös ausschalten könnte, beschreiben Forschende der #CharitéBerlin und des @MDC_Berlin in @ScienceAdvances. charite.de/forschung/paper_s…
Links: Normales Gewebe kehrt nach der Reparatur einer Schädigung in den gesunden Status zurück. Erkennbar sind die von magentafarbenen Epithelzellen ausgekleideten Darmkrypten, nur wenige (grün markierte) Zellen teilen sich. Rechts: Gewebe, dem das P53-Protein fehlt, teilt sich unkontrolliert weiter. © Charité | K. Hartl / M. Sigal

ALT Links: Normales Gewebe kehrt nach der Reparatur einer Schädigung in den gesunden Status zurück. Erkennbar sind die von magentafarbenen Epithelzellen ausgekleideten Darmkrypten, nur wenige (grün markierte) Zellen teilen sich. Rechts: Gewebe, dem das P53-Protein fehlt, teilt sich unkontrolliert weiter. © Charité | K. Hartl / M. Sigal

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Researchers @LabSigal at #mdcBerlin and @ChariteBerlin have elucidated the role of the #p53 gene in #ulcerativecolitis. The study published in @ScienceAdvances suggests a potential new drug target. The research was led by @KimberlyHartl_. Read more: mdc-berlin.de/news/press/can…
Scientific image

ALT Scientific image

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SigalLab retweeted
ISSCR@ISSCR27 Aug 2024
Join us on 10 September for a complimentary #ISSCRDigital webinar featuring the #ISSCR2024 Poster Award Winners! Do not miss their research on cell biology & immunology 👉 bit.ly/46CD012 @CellReproLab @luisfholiveira @kaitlinmccreery @WickstromLab @LabSigal
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SigalLab retweeted
.@gamonasterioo29 Jul 2024
The value of ‘wasting time’ on deep thinking is often overlooked in a scientific ecosystem increasingly tainted by Wall Street’s productivity mindset. nature.com/articles/d41586-0…
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SigalLab retweeted
BaCell3D@BaCell3D19 Jun 2024
Almost time for the #BaCell3D 2024! 🔔 #organoids #basel – at Basel, Switzerland
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Group leaders from both @MDC_Berlin locations dedicated 2 days to meeting & discussing their most recent research interests, exchanging ideas and forging new collaborations at the Topic1/@BIMSB_MDC PI Retreat 2024 #mdcBerlin
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Congratulations to the best PhDs and Postdocs of 2023, awarded by our Association of Friends. The winners for the best papers are Manqiang Lin & Artsemi Yushkevich. Hendrik Bartolomaeus, Eleonore Adami & Ulrike Löber received the Postdoc Awards. mdc-berlin.de/news/news/awar…

Awards for the best PhDs and Postdocs of 2023

Their research is outstanding, and they’re also committed to the Max Delbrück Center and engaged in our community — Manqiang Lin and Artsemi Yushkevich wrote the best papers in 2023; Hendrik Bartol...

mdc-berlin.de
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#Exzellenzstrategie: Nach Entscheidung der #DFG dürfen sich 3 neue Initiativen der #BerlinUAlliance in der Förderlinie Exzellenzcluster bewerben. Mehr Details gibt es hier 👉 berlin-university-alliance.d… @FU_Berlin @HumboldtUni @TUBerlin @ChariteBerlin
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SigalLab retweeted
GSCN@gscn_office25 Jan 2024
On 1 Feb. is Berlin Stem Cell Club with Sarah Hedtrich @hedtrichlab and @JensPuschhof with new insights into @Epithelia research. Join us on-site or online: bit.ly/GSCNBSCC Afterwards get-together to network! @ChariteBerlin @MDC_Berlin @berlinnovation #stemcells
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Wishing all of you wonderful people here a very merry GI Christmas 😅🎄
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Cycles of #paligenosis leave their epigenetic marks on cells even as they redifferentiate, making previously paligenotic cells more plastic for subsequent #metaplasia and #tumorigenesis. One paliG gene possibly involved: 𝘈𝘵𝘧3. Similar to Cyclical Hit Model of tumorigenesis /1
Developmental Cell@Dev_Cell6 Dec 2023
Online now: A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas dlvr.it/SzlmYg
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Very excited to share two papers published today in @CellCellPress describing stem cell plasticity in CRC. (1/22) cell.com/cell/fulltext/S0092… cell.com/cell/fulltext/S0092…
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Happy to see our review issued this month in @AGA_Gastro. Merci for the stellar opportunity and guidance Daniel Stange, input and great exchanges Masanobu Oshima, and special kudos and thank you to Michael Sigal for your awe-inspiring support! Thread ⬇️ gastrojournal.org/article/S0…

Stem Cells, Helicobacter pylori, and Mutational Landscape: Utility of Preclinical Models to...

Several genetic and environmental factors increase gastric cancer (GC) risk, with Helicobacter pylori being the main environmental agent. GC is thought to emerge through a sequence of morphological...

gastrojournal.org
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💡New Insights! Proud to share our @ScienceMagazine research: High-throughput screening in human #organoids illuminates ZNF800 as a key factor in differentiation of the gut cells that make hormones like #GLP1. Learn more about it here: go.roche.com/3xzc9 🔍 #ScienceDiscovery
Hubrecht Institute@_Hubrecht26 Oct 2023
How do stem cells form enteroendocrine cells of the gut? @TheCleversLab, @prinsesmaximac and @MaastrichtU used human gut organoids to answer that question and identified ZNF800 as a key regulator. The results were published in Science today! Read more: hubrecht.eu/traffic-light-gu…
Human gut organoids with and without the transcription factor ZNF800.

ALT Human gut organoids with and without the transcription factor ZNF800.

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IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy by @LaurentBeziaud et al. High-quality paper handpicked by the @CellStemCell editorial team hubs.li/Q026x0700
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Exciting news!✨ Our lab manager Natalia Martagón C. was awarded by the BIH Quest Center for sharing her protocol for a Wnt-3a & R-spo1 conditioned media reporter assay on @protocolsIO Showcasing again the importance of science reproducibility! @BIH_Innovation @questbih
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Our DARLIN paper is out. We hope that this model really enables and facilitates single cell lineage tracing experiments in the mouse. Thanks specially to @Li_Li_666 and @ShouwenW. More exciting uses of the technology coming out soon... cell.com/cell/fulltext/S0092…

A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic...

DARLIN is an inducible barcoding system that allows for lineage tracing and analysis across mouse tissues as well as combined transcriptional and epigenomic single-cell measurements.

cell.com
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Replying to @BIMSB_MDC
@BIMSB_MDC Newbie symposium! Looking forward to interesting PhD presentations. MBL -> CLL and mitochondrial DNA mutations 🔥🔥🔥
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We thank the speakers, organizers and ca. 200 participants of the 16th Berlin Summer Meeting 'The MDC Celebrates 15 Years of BIMSB', 6-7 Sept 2023, for 2 days of superb presentations & discussions on the latest exciting findings in systems biology! @MDC_Berlin #mdcBIMSB2023
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Thanks to everyone who celebrated 15 years of MDC-BIMSB with us! Here are a few impressions from the festivities. Check out the recording in case you missed it: mdc-berlin.de/news/press/max… #mdcBerlin #mdcBIMSB2023 @BIMSB_MDC
Group photo of the MDC-BIMSB PI's and staff on the roof terrace at the Max Delbrück Center's Berlin-Mitte location. © David Ausserhofer / Max Delbrück Center

ALT Group photo of the MDC-BIMSB PI's and staff on the roof terrace at the Max Delbrück Center's Berlin-Mitte location. © David Ausserhofer / Max Delbrück Center

Group photo (l.t.r.): Maike Sander, Scientific Director of the Max Delbrück Center; Nikolaus Rajewsky, Director of the MDC-BIMSB; Heike Graßmann, Administrative Director of the Max Delbrück Center. © David Ausserhofer / Max Delbrück Center

ALT Group photo (l.t.r.): Maike Sander, Scientific Director of the Max Delbrück Center; Nikolaus Rajewsky, Director of the MDC-BIMSB; Heike Graßmann, Administrative Director of the Max Delbrück Center. © David Ausserhofer / Max Delbrück Center

Photo of the panel discussion during the festivities for "15 years of MDC-BIMSB" about "the future of medical systems biology." © David Ausserhofer / Max Delbrück Center

ALT Photo of the panel discussion during the festivities for "15 years of MDC-BIMSB" about "the future of medical systems biology." © David Ausserhofer / Max Delbrück Center

Photo of the anniversary reception on the roof terrace. © David Ausserhofer / Max Delbrück Center

ALT Photo of the anniversary reception on the roof terrace. © David Ausserhofer / Max Delbrück Center

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