@LambeLab

Lambe Lab at University of Toronto, Optophysiology Neurodetectives

 Stanford, Yale, now UTORONTO
discover.research.utoronto.ca/5915-evelyn-lambe/publications
Joined June 2019
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  • Following2.4K
  • Followers994
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Had such a great time working on this with @jblaze8911, from post-talk idea to publication. So happy to see it out in @npp_journal! Congratulations @EricJNestler @AkbarianLab @VannaZachariou
Dr. Jennifer Blaze@jblaze891112 Feb 2024
We're so proud of the team effort that went into this one! Check out our recent publication in @npp_journal linking tRNA epitranscriptomics with opioid use @JDCalebBrowne @EricJNestler @AkbarianLab @VannaZachariou nature.com/articles/s41386-0…
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Our latest #preprint on touch encoding in rodent mechanoreceptors is out now! 👈 🔗 biorxiv.org/content/10.1101/… Many thanks to the huge, collaborative effort from the @PrescottLab that spans (most of) my PhD! 🥳(@Chris_Dedek @AHalawa99 @SickKidsNews @bme_uoft) (1/4)

Encoding of vibrotactile stimuli by mechanoreceptors in rodent glabrous skin

Somatosensory coding in rodents has been mostly studied in the whisker system and hairy skin, whereas the function of low-threshold mechanoreceptors (LTMRs) in rodent glabrous skin has received scant...

biorxiv.org
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New work from my lab led by Hongli Wang and @heatherkortega. We studied ACh and NE signaling in the mouse medial frontal cortex, while the animal 🐭 plays a competitive game with a computer 🖥️. biorxiv.org/content/10.1101/…
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1/Today is #BellLetsTalk Day! Dr. @rajjitarek Executive Director of TDRA, et al, received a @Bell_LetsTalk/@BrainCanada grant to advance their research on enhancing theta burst stimulation for #depression. Read parts 2 and 3 for updates on the work!
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2/Ex vivo work is progressing @LambeLab with a new calcium-imaging approach pioneered by @Sridevi292. Spacing episodes of stimuli ⚡️ appears more efficient. Next steps by @zolis_a.
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Excited to share the new preprint from the lab. We found that early life stress (ELS) disrupts the brain-wide functional connectivity of the raphe nucleus and parsed out the individual circuits to rescue ELS-induced anxiety @RamkumarRaksha @moriah_edge @DTerstege @nk_sakib
bioRxiv Neuroscience@biorxiv_neursci2 Aug 2023
Long-term impact of early life stress on serotonin connectivity biorxiv.org/cgi/content/shor… #biorxiv_neursci
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1/3 New serotonin (5-HT) GRAB sensors! We developed largely-improved green and all-new red genetically encoded fluorescent 5-HT sensors for dual-color imaging in vivo. Using these new 5-HT sensors, we are able to simultaneously monitor 5-HT and other neurochemicals.
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Thank you @BrainCanada for supporting and highlighting this translational project and very grateful for my co-PIs @collingridge_l @LambeLab @SanjSockalingam and the teams @TorontoDementia Research Alliance @CAMHnews @uoftmedicine @tanzuoft #BenchToBedsideNeuroscience
Kate Shingler@KateShingler15 Jan 2023
Learn more about improving depression treatments through translational research ➡️ The Montrealer @BrainCanada is proud to support your research @RajjiTarek. Thanks to @Bell_LetsTalk and the Government of Canada for investing in #mentalhealth #research. themontrealeronline.com/2023…
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1/8 Are all synapses created equal? @clembrnrd in @Rico_lab and @Marinlab has found that the building of new synapses is controlled in a cell-type and even synapse-type-specific manner. This is the story @ScienceMagazine science.org/doi/10.1126/scie… ⬇ thread @dev_neuro @MRC_CNDD

Cortical wiring by synapse type–specific control of local protein synthesis

Local protein synthesis is regulated within connectivity motifs to control synapse formation in the mouse nervous system.

science.org
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#InfosysPrize2022 in Life Sciences is awarded to Vidita Vaidya, @TIFRScience, for her fundamental contributions to understanding brain mechanisms that underlie mood disorders such as anxiety and depression, including signals engaged by the neurotransmitter serotonin... (1/2)
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Excited to be here at #SfN2022 ! Come chat with me about cholinergic deficits in aging & nicotinic rescue by xanomeline on Monday afternoon at poster D31!
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Excited to present our work at #SfN2022 🧠 in San Diego. 👉 Tuesday 11am-12pm Medial prefrontal serotonin input regulates cognitive flexibility in mice (XX6) 🗣 Come by our poster if you are interested in hear more. @AshleaIsHere @mark_ansorge @SaigePower @d_sargin @LambeLab
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I'm so excited to be at #SfN2022 this week! My lab has 3 posters on neocortical cell types and large-scale transcriptomics.
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Our (@JKhokharLab) book chapter "The Relationship Between Cannabis, Cognition, and Schizophrenia: It’s Complicated" by @hakan_kayir, @jessicascience and Patrick McCunn is out! Thank you @JaredWYoung and @BarchDbarch for the invitation! link.springer.com/chapter/10…

The Relationship Between Cannabis, Cognition, and Schizophrenia: It

The consequences of cannabis use, especially in the context of schizophrenia, have gained increased importance with the legalization of cannabis in North America and across the globe. Cannabis use...

link.springer.com
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Costumes to scare scientists #academictwitter
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Congratulations Dr. Sheena Josselyn @sjo09 @theNAMedicine Class of 2022 !!!
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"GABA-A receptors located at or near nodes of Ranvier of sensory axons cause this facilitation by preventing spike propagation failure at the many axon branch points, which is otherwise common without GABA" nature.com/articles/s41593-0…

GABA facilitates spike propagation through branch points of sensory axons in the spinal cord

Nature Neuroscience - This study shows that, rather than causing inhibition, axonal GABAA receptors often facilitate sodium channel activation and prevent spike propagation failure at branch points...

nature.com
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Staff Pick 2022: “If you truly love n̶a̶t̶u̶r̶e̶ neuroscience, you will find beauty everywhere” by @SeanKeato (Queensland Brain Institute). The words of Vincent van Gogh and beautiful swirling structure of the hippocampus inspired this recreation “The Starry Night”. #AoN2022
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Happy birthday to our esteemed neuroscientist Brenda Milner! 🎁She is celebrating 104 years old today. To learn more about her distinguished life and career, visit: mcgill.ca/neuro/about/brenda…
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Serotonin dynamics in vivo! We now have new green and red serotonin (5-HT) GRAB sensors enabling detection of 5-HT dynamics in different brain regions and conditions, also suitable for dual-color imaging! #GRABSensors #serotonin @5HT_Society
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