Studying how organs form & making artificial kidneys. Group leader at the Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research.
Joined February 2020
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Nils Lindstrom retweeted
Synthetic Organizers Aid Creation of Reproducible Kidney Organoids from Stem Cells
Synthetic organizers provide a way to control formation of #kidneyorganoids as more reliable models for studying disease, evaluating potential therapies
@LindstromLab @USC
hubs.li/Q04nBGTy0
First and foremost we need to make good quality proximal tubule cells. These will serve all therapeutic development to make safer drugs with fewer side effects; a pharmacokinetic toolkit! Currently at #LABioStart to learn how we build a company to provide these as a service.
Nils Lindstrom retweeted
Kidney cells from stem cells. Yep, it's happening.
Nils Lindström, PhD, of the @LindstromLab at @USCStemCell explains the process of turning stem cells into organoids, a pathway to identifying new treatments for kidney disease.
Well done to MaryAnne Achieng who has made microscopy of organoids an artform.
How do you break symmetry along a cell planar axis? Of course WNT/BMP/FGF/NOTCH compete and talk. Each nephron is like an embryo patterning along its AP axis. @LindstromLab @USCStemCell
doi.org/10.1101/2025.03.29.6…
Nils Lindstrom retweeted
How do you break symmetry along a cell planar axis? Of course WNT/BMP/FGF/NOTCH compete and talk. Each nephron is like an embryo patterning along its AP axis. @LindstromLab @USCStemCell
doi.org/10.1101/2025.03.29.6…
How do you break symmetry along a cell planar axis? Of course WNT/BMP/FGF/NOTCH compete and talk. Each nephron is like an embryo patterning along its AP axis. @LindstromLab @USCStemCell
doi.org/10.1101/2025.03.29.6…
Great to have the chance to discuss the future of kidney organoid technologies and the basis of kidney development & function with Jess @JMVanslambrouck Looking forward to more collaborations and insights to make next generation stem cell derived kidney models!
Pleased to be sharing this chapter written with Nils @LindstromLab for Current Topics in Developmental Biology! Here we dive into how #nephrons establish proximal-distal patterning during #KidneyDevelopment & what this means for #StemCell-derived nephrons: authors.elsevier.com/a/1kWLp…
Nils Lindstrom retweeted
Pleased to be sharing this chapter written with Nils @LindstromLab for Current Topics in Developmental Biology! Here we dive into how #nephrons establish proximal-distal patterning during #KidneyDevelopment & what this means for #StemCell-derived nephrons: authors.elsevier.com/a/1kWLp…
Nils Lindstrom retweeted
Check out Mark Corkins’ collaborative preprint with @AdRoMora from our lab and MaryAnne Achieng from @LindstromLab using comparative single-cell sequencing and in situ to create this beautiful spatial model of the developing adult frog kidney!
biorxiv.org/content/10.1101/…
Nils Lindstrom retweeted
The outer ear is a mammalian innovation but where did it come from? In our study in @Nature, @MathiThiru95 and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. nature.com/articles/s41586-0…
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Such a great collaboration with @LeonardoMorsut and his team - am now certain that the way forward is through collaborations like these where devbio and synbio co-develop concepts. #wewillbuildakidney
tldr: we identify a new organizer activity in vivo in human developing kidney, noticed the lack of said organizing activity in kidney organoids and reconstituted the organizer action in vitro via synthetic organizers - longer thread on bluesky!
@LindstromLab
Nils Lindstrom retweeted
tldr: we identify a new organizer activity in vivo in human developing kidney, noticed the lack of said organizing activity in kidney organoids and reconstituted the organizer action in vitro via synthetic organizers - longer thread on bluesky!
@LindstromLab
Nils Lindstrom retweeted
Genes aren’t the sole driver instructing cells to build multicellular structures. In a paper in @NatureComms, @USCStemCell scientist @LeonardoMorsut and @Caltech computational biologist Matt Thomson characterize the influence of cell density. stemcell.keck.usc.edu/exerti…
Nils Lindstrom retweeted
I am excited to share our work discovering neuro-endothelial cells (NECs) - a subtype of #endothelial cells that regulate #brain and #kidney blood flow and #immune balance - now available online! Movie: NECs (green) in the mouse motor cortex #vasculature. biorxiv.org/content/10.1101/…
Nils Lindstrom retweeted
How similar is kidney development in humans and in lab mice that form the foundation of basic medical research? In a new study published in @Dev_Cell, @USCStemCell scientists probe this question. @AndyMcMahonLab @LindstromLab @KeckSchool_USC stemcell.keck.usc.edu/study-…
Nils Lindstrom retweeted
We have two 1-year positions with a 1-year renewal option available for clinical trainees interested in conducting research related to stem cell biology and/or regenerative medicine in one of the leading labs @USCStemCell. @KeckSchool_USC stemcell.keck.usc.edu/2024-c…
Nils Lindstrom retweeted
A new @USCStemCell study, led by Zhongwei Li's Lab (@LiLab_Kidney), introduces a new and improved way to grow the cells that give rise to the kidney’s filtration system. @AndyMcMahonLab @LindstromLab @ukrocharity @CellPressNews @NIH_CommonFund stemcell.keck.usc.edu/usc-le…
Congratulations to all on this milestone paper from Zhongwei Li’s group! Self renewing nephron progenitors in a dish opens exciting avenues for kidney research!!
authors.elsevier.com/c/1j0HC…
@USCStemCell
@LiLab_Kidney
Nils Lindstrom retweeted
Celebrating #WorldKidneyDay with @ukrocharity and Zhongwei Li’s lab @USCStemCell and @KeckSchool_USC. @LiLab_Kidney and colleagues @AndyMcMahonLab, @LindstromLab and @JPetiPeterdi are progressing on generating a transplantable kidney from human stem cells to replace dialysis.