Mark Biscone

A big step forward vs cancer nature.com/articles/d41586-0…

Ultraprocessed foods and increased all-cause mortality A dose relationship from 8 countries, ~240,000 participants, and ~15,000 deaths ajpmonline.org/article/S0749…

A new blood biomarker for Alzheimer's disease accurately tracks Tau protein aggregate build up in the brain nature.com/articles/s41591-0…

Do viruses play a role in the cause of Alzheimer's disease? In the wake of observational studies showing some protection from the vaccines vs. shingles economist.com/science-and-te… Unclear, but an ongoing clinical trial of valacyclovir, an anti-viral, may help to resolve

How multimodal A.I. of real time smartwatch data can automatically detect a person's loss of pulse—sudden cardiac death—and notify emergency services nature.com/articles/s41586-0… @GoogleDeepMind @jesunshine @Nature

Peto's Paradox—that cancer does not increase with body size of mammals—was wrong. A new, comprehensive study of 263 species documents higher cancer prevalence with increasing body mass. Some large animals (e.g. elephants) have some built-in genetic adaptations pnas.org/doi/10.1073/pnas.24…

Fully preventable deaths and hospitalizations from a disease that was eradicated here, with much more to come.

The immune response from the Covid boosters introduced last September is holding up very well against current circulating variants 👍thelancet.com/journals/lanin…

A very innovative approach to cancer: engineering fat cells to convert to beige fat to starve tumors, outcompeting 5 types of cancer in experimental models nature.com/articles/s41587-0… @NatureBiotech @NadavAhituv @UCSFMedicine

I wouldn't have anticipated this one! Preventing or treating hypertension through a gut microbiome intervention, in both mice and a pilot study in people cell.com/cell-metabolism/abs… @Cell_Metabolism

We knew about the potential origin of Parkinson's disease from the gut (known as Braak’s hypothesis). But the kidney?! nature.com/articles/s41593-0… @NatureNeuro

A generalist #AI LLM medical model that improves accuracy of physician diagnosis across 8 specialities for common and rare diseases nature.com/articles/s41591-0… @NatureMedicine

Cytomegalovirus (CMV) is the leading cause of infectious birth defects and linked to many other morbidities such as transplantation. For the first time in over 50 years of pursuit, a vaccine is in reach jci.org/articles/view/182317

The scientist who is responsible for driving GLP-1 drugs for the treatment of obesity and testing them for prevention of Alzheimer's disease—Lotte Bjerre Knudsen— tells her story in a remarkable conversation. Full transcript, or video, all free, no ads. Link in my profile, Ground Truths.

Generative #AI accuracy outperformed experts for detection of ovarian cancer via ultrasound nature.com/articles/s41591-0… @NatureMedicine

"A healthy mind is a healthy immune system" How can we prevent age-related changes of the immune system to preserve brain fitness? by @basurco_leyre @maabellanas and colleagues @WeizmannScience an insightful perspective, open-access @NeuroCellPress cell.com/neuron/fulltext/S08…

Two new studies zero in on the anti-inflammatory effects of the GLP-1 family of drugs, independent of weight loss, highlighting the gut-brain axis (modulating TLR response) and the gut GIP impact by @DanielJDrucker and colleagues cell.com/cell-metabolism/ful… @Cell_Metabolism insight.jci.org/articles/vie… @JCI_insight

Among ~9 million Americans, representing over 440 occupations, who had the lowest proportion of #Alzheimers disease related deaths? Ambulance and taxi drivers bmj.com/content/387/bmj-2024… ? benefit of spatial and navigational processing

If you like dark chocolate, you'll like this finding from today that it reduces the risk of developing Type 2 diabetes (not seen with milk chocolate) [in 3 large prospective cohorts, with the usual caveats of epidemiological, observational nutrition studies]🍫🍫