Hibbert Professor of Bioengineering @pennbioeng | Lipid Nanoparticles | mRNA Therapeutics & Vaccines | Drug Delivery | Biomaterials | Immunotherapy
University of Pennsylvania
Joined August 2011
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Excited to share our latest @NatureNano led by @MJMitchell_Lab Postdoctoral Fellow @ShiQiangqiang on a new class of ionizable lipids that act as prodrugs to create an in situ vaccine within solid tumors that also eradicate distant tumors!
Free access: rdcu.be/e8Lq6
Mitchell Lab is ready to rock in Orlando for the @BMESociety Annual Meeting! Come check out talks by @hannahyamagata on saRNA LNPs for pancreas and adipose tissue delivery (today 445pm), @Anushka1Agrawal on anionic phospholipids to enhance mRNA placental delivery (Friday 5pm)
We are hiring faculty @pennbioeng at the Assistant/Associate/Full Professor levels! I will be at the @BMESociety Meeting this week, and look forward to connecting at the Meet the Faculty Candidate Session and our Penn reception Thursday 7PM!
Details: be.engineering.upenn.edu/abo…
Mike Mitchell retweeted
Young Innovator, Karin Wang @templebioe , will present “Tumor-Associated Fibroblast-Derived Matrix Containing EDA-FN Alters Macrophage Behavior” on 10/23 at 3:00 PM in Crystal M. #BMES2026 @BMESociety
The full paper will appear here soon:
link.springer.com/collection…
Mike Mitchell retweeted
Daeyeon Lee has received the 2026–27 George H. Heilmeier Faculty Award for Excellence in Research for his advances in understanding and exploiting interfacial phenomena in soft matter and biomaterials. Lee is the Russell Pearce and Elizabeth Crimian Heuer Professor in @CBE_Penn.
The Heilmeier Lecture will take place in Spring 2027.
bit.ly/3TUvf4D
Mike Mitchell retweeted
Join us as we welcome Claudia Loebel to our next episode of #TissueTalks as she discusses, "Mapping the Nascent Extracellular Matrix in Tissue Remodeling and Repair"
Register now👉 columbiauniversity.zoom.us/w…
Mike Mitchell retweeted
Super exited to share our latest review in Chem led by Dr. Bowen Wu and Dr. Xuehe Lu in collaboration with @MJMitchell_Lab on discussing synthesis and optimization of ionizable lipids for RNA delivery! Free access: authors.elsevier.com/a/1nqbf…
Mike Mitchell retweeted
We’re hiring.
The Department of Bioengineering is seeking faculty at the Assistant, Associate and Full Professor levels across bioengineering as part of a multi-year hiring initiative.
Applications due Nov. 23, 2026.
Learn more + apply: be.engineering.upenn.edu/abo…
@PennEngineers
ALT Promotional graphic for an open faculty position in Penn Bioengineering. Large white text on a dark blue background reads, “OPEN FACULTY POSITION” and “Help Shape What’s Next in Bioengineering.” Two overlapping red-outlined diamond-shaped photos show Bioengineering researchers working in a laboratory and a faculty member standing in a lab. The Penn Engineering and Department of Bioengineering logos appear above a white “APPLY NOW” button.
Check out our latest in Nature Reviews Chemistry @NatRevChem led by Mitchell Lab Postdocs @Lulu_Xuee and Melgious Ang on the structural evolution of ionizable lipids for lipid nanoparticle nucleic acid delivery!
Free access to the article: rdcu.be/UzqCiHjPXn7a
Check out our latest News and Views @NatureMaterials led by @MJMitchell_Lab PhD student Emily Fitzgerald and Postdoc Marshall Padilla on Huayu Tian's polymer LNPs that target, activate and generate CAR T cells in vivo for fibrosis therapy!
Free access: rdcu.be/Pm9tDUyooTza
Check out our latest comment in Nature Chemical Engineering @NatChemEng led by @MJMitchell_Lab PhD student @_emilyhan_ on systems-level design of lipid nanoparticles for targeted RNA delivery!
Free access: rdcu.be/fJWn7CEx1B7a
Check out our latest @natBME News and Views led by @MJMitchell_Lab Postdoc Zhangyi Luo and PhD student Audrey Zhu on Tuo Wei and Shuquan Rao's recent work on targeted LNPs for direct bone injection for durable hematopoietic stem cell gene editing!
Link: nature.com/articles/s41551-0…
Mike Mitchell retweeted
Thrilled to share our Fanzor2 genome-editing work @NatureBiotech! We developed FanzMAX, a compact genome editor, by combining AI-assisted protein evolution, ωRNA engineering, and in vivo delivery. Huge thanks to all co-authors, and collaborators for making this work possible!
Adaptive model-guided protein evolution with sparse data optimizes compact eukaryotic genome editors - @XueSherryGao nature.com/articles/s41587-0…
Mike Mitchell retweeted
Penn researchers have built the first spatial map of the developing human kidney, analyzing more than 700,000 cells to show how soluble signals from neighboring cells guide development.
The study was conducted by the Penn-CHOP Kidney Innovation Center, a collaboration between @PennMedicine and @ChildrensPhila, in partnership with Penn Engineering and the @IRM_UPenn.
"The kidney is a physical structure, and physical context is not incidental to how it forms—it is instructive," says Alex J. Hughes, Associate Professor in @PennBioeng, who co-led the study.
bit.ly/4hrJYgO
Check out our latest in Advanced Materials led by recent @MJMitchell_Lab PhD @ASThatte2 in collaboration w @JilianMelamed @WeissmanLab on a steroid LNP platform for mRNA delivery while mitigating inflammation for treating autoimmune disease!
Open access: doi.org/10.1002/adma.74301
Congrats to all authors: Ben Nachod, Julia Baena, Jenna Muscat-Rivera, @hannahsafford_, @HannahGeisler_, @hannahyamagata, Melgious Ang, Michael Kegel, @lexandrePoirier, Elaine Tong, Monica Zhong, @ShiQiangqiang, @JinjinWang40973, Elisa Battistini, Ye Zeng, @a_hmltn @SwingleKelsey
Excited to recruit Steven H. Bernstein to Liberate Bio as our Chief Medical Officer as we push towards the clinic with our in vivo cell reprogramming lipid nanoparticle technology!
businesswire.com/news/home/2…
Mike Mitchell retweeted
🏆 #FIFAWorldCup
⚽ #Argentina 2 (Enzo Fernández y Lautaro Martínez) 🆚 #Inglaterra 🏴 1 (Anthony Gordon)
👉 ¡Final del partido!
🔥 Imposible no ilusionarse... ¡vamos, un pasito más!
