Assistant Professor | UConn. Studying senescence and age-related skeletal disease. Husband, dad, and heavy metal enthusiast.
Joined September 2021
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I am thrilled to announce I will be starting my own lab this spring in the Center for Regenerative Medicine and Skeletal Development at @uconnhealth! Incredibly grateful for all who have supported me to this point, this is a dream come true!
Madison Doolittle retweeted
Happy reading, by @DrGustavoDuque Giovanni Lombardi and I. @UniMelbMDHS
Bone and muscle crosstalk in ageing and disease | Nature Reviews Endocrinology nature.com/articles/s41574-0…
Was so honored to receive the #ASBMR2024 Most Outstanding Translational Abstract Award; a result of the wonderful mentorship of @skhosla78 and team at @MayoClinic. Looking forward to many more meetings to come representing @uconnhealth!
Always great meeting new friends, and even better seeing old ones! Congrats @DrBenKirk on your well-deserved awards! Even though we nearly burnt the house down (@DrGustavoDuque @DrAhmedAlSaedi)
Madison Doolittle retweeted
New #research by 3 AFAR Grantees in @NatureMedicine suggests that drugs targeting #senescentcells may benefit healthy older women but not "one-size-fits-all."
Explore here: mayocl.in/4cOBiLG
@NKLeBrasseur @MadisonDoolitt3 @MayoClinic @UConnHealth
Madison Doolittle retweeted
Effect of senolytics (D+Q) on bone metabolism in postmenopausal women – a phase 2 RCT. Findings indicate that D+Q increased bone formation but did not reduce bone resorption. The clinical response to senolytics is driven by underlying senescent cell burden
nature.com/articles/s41591-0…
New manuscript co-led with @skhosla78 and the man himself @dominiksaul88 where we define senescence in the healing fracture callus at the single-cell level! @MayoClinic @jclinicalinvest
jci.org/articles/view/179834
See associated commentary, nicely put by Hofbauer et al:
jci.org/articles/view/181974
Huge effort by @dominiksaul88, which included a transcontinental flight from Germany to Minnesota for a final set of experiments. Big thanks to all involved!
Madison Doolittle retweeted
Finally published in #JCI P21+ senescent cells play a crucial role in fracture healing:
jci.org/articles/view/179834
Targeting these cells potentially boosts fracture healing 🦴. Thanks to @MadisonDoolitt3 @skhosla78 and the @MayoClinic #aging #fracture #bone
It has been an amazing 4 years at Mayo Clinic that I will forever cherish. I can't thank @skhosla78 enough for taking a bet on me and teaching me all there is to know about academic research. It has been one of the best experiences of my life.
Excited to share our most recent work, together with @dominiksaul88 and @skhosla78, on deeply characterizing #senescence during fracture healing. We find the cells delaying repair are a diverse mix of p21+ cells, which can be targeted to enhance healing.
biorxiv.org/content/10.1101/…
Madison Doolittle retweeted
Clever bioinformatic + cell-based approaches by @XuZhang_Mayo and our @MayoClinic colleagues @MadisonDoolitt3, @skhosla78, + others to unravel how #senescent cells (FAPs) drive features of skeletal muscle #aging: @AgingCell onlinelibrary.wiley.com/doi/… #sarcopenia
Madison Doolittle retweeted
Our new preprint sheds light on the distinct role of p16- and p21-associated SASP across tissues and species.
biorxiv.org/content/10.1101/…
No time? Just listen to this very cool 90 sec. summary: lnkd.in/eQmY97xP
@PassosLab @MadisonDoolitt3 @RobynKosinsky @NKLeBRASSEUR
Madison Doolittle retweeted
The senescent cells that drive #aging related diseases are notoriously hard to identify —but now Mayo researchers have done just that. They’ve developed a new technique to pinpoint these rare cells in bones, where they can lead to #osteoporosis. mayocl.in/3ZK2Gp2
Madison Doolittle retweeted
Very excited to receive the @ASBMR “Most Outstanding Translational Abstract Award” for my talk on Oct 13th- 1001: on #breastcancer and osteocyte senescence. w/ @mani85phd @hayley_sabol @aricanloague , others & PI @DelgadoCalleJ #ASBMR2023. @uams_physiology @uamshealth @uamscancer