@RobynKosinsky
 Germany
Joined August 2015
  • Tweets23
  • Following43
  • Followers47
Robyn Kosinsky retweeted
Dominik Saul@dominiksaul8816 May 2023
Check out our commentary on spatial transcriptomics published in Clinical and Translational Medicine (doi.org/10.1002/ctm2.1264) . This methods allows us to analyze gene expression patterns in a tissue sample while preserving spatial information

Spatial transcriptomics herald a new era of transcriptome research

Click on the article title to read more.

onlinelibrary.wiley.com
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul8825 Feb 2023
An old bisphosphate friend may help to alleviate the burden of senescence: Samakkarnthai et al. demonstrate this in vitro and in vivo biorxiv.org/content/10.1101/… @Samakkarnthai @MayoClinic @skhosla78 @MadisonDoolitt3 @sfeirjad @Japneet__Kaur_ @NKLeBRASSEUR @aging #bone #aging

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory...

In addition to reducing fracture risk, zoledronate has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals. Because senescent cells accumulate...

biorxiv.org
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul8822 Feb 2023
What happens if you remove senescent cells from bone locally as compared to systemic senolysis? Amazing work by Farr and the Khosla Lab: JCI - Local senolysis in aged mice only partially replicates the benefits of systemic senolysis jci.org/articles/view/162519… @jclinicalinvest
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Robyn Kosinsky retweeted
Gui Ramos MD@GuiRamosMD1 Feb 2023
🚨In this month’s edition of @AGA_Gastro our group @FaubionWilliam Lab, shows how inhibitors of the epigenetic enzyme G9a can metabolic reprogram Tcells into Treg capable of controlling Intestinal Inflammation. Cell engineering & Epigenetic Modulation as potential novel #IBD txs
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul8812 Jan 2023
Ever wondered why some bones 🦴do not heal? We outline answers from basic research and the clinic: Bone Healing Gone Wrong: Pathological Fracture Healing and Non-Unions—Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors mdpi.com/2058992
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul889 Sep 2022
Awesome presentation by @skhosla78 on fracture healing and the impact of p21-driven cellular senescence at @ASBMR #ASBMR2022,thanks to @MadisonDoolitt3 @Japneet__Kaur_ @RobynKosinsky and the KhoslaLab #fracture #bonehealing #aging #senescence #science #research #bone @MayoClinic
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul8816 Aug 2022
Do you want to detect senescent cells in your sequencing dataset? Or monitor your senolytic therapy? SenMayo can help you: rdcu.be/cTL9h @natcomms #senescence #aging #research #SASP #Bioinformatics @NextGenSequence @skhosla78 @MadisonDoolitt3 @RobynKosinsky @PassosLab
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul887 Jul 2022
Doolittle et al. use a new ERαΔOcy mouse model to decipher the mechanism of ERα action in bone: Skeletal Effects of Inducible ERα Deletion in Osteocytes in Adult Mice asbmr.onlinelibrary.wiley.co… #bone #jbmr #estrogen @skhosla78 @MadisonDoolitt3 @Japneet__Kaur_ @MegVoda

Skeletal Effects of Inducible ERα Deletion in Osteocytes in Adult Mice

Estrogen is known to regulate bone metabolism in both women and men, but substantial gaps remain in our knowledge of estrogen and estrogen receptor alpha (ERα) regulation of adult bone metabolism....

onlinelibrary.wiley.com
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul8824 Feb 2022
Check out our review in #EndocrineReviews: Fracture healing and how it is affected by endocrine diseases, aging, and cellular senescence: academic.oup.com/edrv/advanc… #fracture #Healing #bonehealing #bone #aging #senescence @OrthoToday @MayoClinicEndo @MayoClinic @skhosla78

Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence

Abstract. More than 2.1 million age-related fractures occur in the United States annually, resulting in an immense socioeconomic burden. Importantly, the a

academic.oup.com
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Robyn Kosinsky retweeted
Fabian Theis
@fabian_theis31 Jan 2022
Interested in spatial omics? Plz check out our squidpy tool, bringing together omics & image analysis to enable a scalable description of spatial molecular data. Out today @naturemethods thx to @g_palla1, @HannahSpitzer1 & team! nature.com/articles/s41592-0… github.com/theislab/squidpy
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Robyn Kosinsky retweeted
nature
@Nature11 Jan 2022
Inflammation in the gut is encoded by neurons in the brain go.nature.com/34tetPR
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul8812 Dec 2021
Senescence is more than just p16 and p21: We developed an in silico approach to reveal cells high in the SASP. SenMayo🧑‍🔬 biorxiv.org/content/10.1101/… #aging #senescence @MayoClinic @SingleCellMedia @scell_papers @skhosla78 @MadisonDoolitt3

A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues

Although cellular senescence is increasingly recognized as driving multiple age-related co-morbidities through the senescence-associated secretory phenotype (SASP), in vivo senescent cell identific...

biorxiv.org
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul8811 Nov 2021
We linked aging to cancer on a single cell level: Single-Cell Transcriptomics Reveals the Expression of Aging- and Senescence-Associated Genes in Distinct Cancer Cell Populations 🧬🥼mdpi.com/1353560 #mdpicells #aging #Cancer @scell_papers @ScPapers @MayoClinic
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul8827 Oct 2021
Happy to share our latest work about CRP in primary hip arthroplasty: mdpi.com/1331618 #mdpijcm via @JCM_MDPI Here we develop an algorithm predicting an early infection after hip arthroplasty at day 5 with a sensitivity of 87.5% 🧐💪 #orthotwitter #surgery #CRP #infection

Predicting the Exception—CRP and Primary Hip Arthroplasty

Background: While primary hip arthroplasty is the most common operative procedure in orthopedic surgery, a periprosthetic joint infection is its most severe complication. Early detection and predic...

mdpi.com
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul887 Oct 2021
Very happy that our eLIFE paper is finally out: We demonstrate for the first time that senescent cells accumulate in the fracture callus. Their clearance improves bone healing. doi.org/10.7554/eLife.69958 @eLife #khoslalab #bonehealing #fracture #mayo #orthotwitter @skhosla78
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul881 Oct 2021
Happy to receive a Young Investigator Award @ASBMR 2021 @MayoClinicEndo #agingresearch #SanDiego @MayoClinic #ASBMR2021 @uniGoettingen – at San Diego, CA
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Robyn Kosinsky retweeted
Dominik Saul@dominiksaul888 Mar 2021
Check out our new and easy approach to detect infectious complications using a generally available biomarker in spinal surgery rdcu.be/cgngM #CRP #ESJ #surgery #spondylodesis
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😃👍🏻Our new publication is now available online: The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells clinicalepigeneticsjournal.b… #CancerResearch #colorectalcancer
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