Collaborative Microbial Metabolite Center

UC San Diego
Joined October 2024
Super exciting study linking diet to Colibactin producing bacteria and its impact on CRC. Check out our MOTM highlight on this at cmmc.gnps2.org or x.com/MicrobialCMMC/status/1…
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antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation academic.oup.com/nar/advance…
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Thanks to all our lovely collaborators for this accomplishment!
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We are back again with the April Molecule of the month featuring Colibactin! Check out more at cmmc.gnps2.org
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Thrilled to share our latest research out today in @Nature: “Microbial metabolite drives ageing-related clonal hematopoiesis via ALPK1” nature.com/articles/s41586-0…
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Happy March! While there’s so much to say about our friendly neighborhood Riboflavin, here we show some highlights. It’s amazing how we can engineer bacteria for commercial production! Check out more at cmmc.gnps2.org
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Have we finally discovered what a “normal” gut #microbiome looks like? Analysis of 45,454 microbiomes from 42 countries identified the Health-Associated Core Keystone (HACK) index, linking certain microbial profiles to lifestyle, disease, and health. cell.com/cell-reports/fullte…
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got microbial metabolites? Add to the public knowledgebase available through GNPS2! cmmc.gnps2.org
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#CIMM2025 Speaker Spotlight: @lizljohnson’s research program focuses on understanding how lipids mediate diet-microbiome-host interactions with the goal of manipulating these interactions for the benefit of host health. Catch her presentation on Day 1!
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What if the gut microbiome drives sugar cravings? New research found the bacterium Bacteroides vulgatus was causally linked to intake of sugar, with pantothenic acid being the key metabolite involved: loom.ly/zce4bWU
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Check out our approach toward disciformycin and gulmirecin, spearheaded by @PeterRuehmann. @nyuchemistry @PennChemistry pubs.acs.org/doi/10.1021/acs…
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Akkermansia muciniphila is a promising target for managing obesity and type 2 diabetes However, this randomized trial reveals that the metabolic benefits of A. muciniphila supplementation could depend on its baseline intestinal levels: loom.ly/3z-rHwU
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Was great to see this AMAZING talk by Robert Quinn of @Quinn_Labs here at UCSD. This talk included a history of the discovery of amine conjugated bile acids, the enzymology behind them, and their impact on health and disease. Some featured papers in his talk shared below:
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