Head of the Laboratory of Aging Biology (LaBE) |University of Campinas, Brazil. Interested in aging, metabolism and adipose biology. Opinions are my own.
Campinas, Brasil
Joined November 2017
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Marcelo A. Mori retweeted
Da inicio el simposio “How Adipose Tissue Talks to the Body: DICER, microRNAs, and Metabolic Control” en el #ICO2026, con el Profr. Marcelo A. Mori @MoriLabe, profesor asociado del Instituto de Biología. @labemori
Abrimos hilo de su ponencia🧵
#Obesidad #SaludGlobal #Obesity #HealthSystems #NCDs #México
Happy to give a talk at the @ceinbio meeting in Rivera, Uruguay. Awesome to be invited to discuss science with this wonderful group of scientists 🙌🏻 – at Sant'Ana do Livramento, Brasil
Marcelo A. Mori retweeted
#Throwback
REVIEW | @MoriLabe et al
Determinants of obesity in Latin America
nature.com/articles/s42255-0…
Semaglutide - perhaps a new way to counteract adipose tissue-driven systemic aging? This new preprint suggests so... – at Campinas, Brasil
The geroscience community has been buzzing, and we finally have informative data on semaglutide (a GLP-1 RA) and epigenetic age! 🧬⏳
After adjusting for inflammation and other factors, a 32-week, double-blind, placebo-controlled trial found semaglutide significantly decreased epigenetic age (e.g., GrimAge -2.3 years, PhenoAge -4.9 years) in adults with HIV-associated lipohypertrophy.
The likely mechanism? Semaglutide's ability to reduce visceral fat may mitigate "adipose-driven pro-aging signals" and even reverse "obesogenic epigenetic memory."
Big picture: more post-hoc analyses of human clinical trials are crucial for establishing causality in longevity research.
Caution: 1) not yet peer reviewed. 2) Additional validation in HIV negative individuals is needed.
Michael J. Corley,Grace A. McComsey (2025) Semaglutide Slows Epigenetic Aging in People with HIV-associated lipohypertrophy: Evidence from a Randomized Controlled Trial medrxiv.org/content/10.1101/…
Marcelo A. Mori retweeted
#Throwback
REVIEW | @MoriLabe et al
Determinants of obesity in Latin America
nature.com/articles/s42255-0…
Marcelo A. Mori retweeted
We wrote a thing on mitochondrial coupled versus uncoupled respiration 🔥
onlinelibrary.wiley.com/doi/…
Marcelo A. Mori retweeted
Awesome to see the @UN highlight the biology of aging.
It was great to contribute - together with many other colleagues - to this brief by the @ScienceBoard_UN to the UN Secretary-General @antonioguterres
un.org/scientific-advisory-b…
Super happy to have contributed to this one! Made possible by an awesome South American collab led by Carlos Escande and Carlos Batthyány at @IPMontevideo and Eduardo Chini at @MayoClinic 🙌 – at Campinas, Brasil
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss go.nature.com/3SZcRDD
Marcelo A. Mori retweeted
Medicamento experimental para controle de peso aumenta gasto energético e não afeta o apetite. Em modelo animal, molécula foi capaz de prevenir acúmulo de gordura e tratar a obesidade já instalada. Primeiros estudos em humanos atestam segurança do composto agencia.fapesp.br/55066
Marcelo A. Mori retweeted
REVIEW | @AnneloftSdu, MP Emont, E Rosen et al. (@bmbSDU, @UChicago, @harvardmed):
A roadmap towards achieving consensus on #singlecell transcriptomics data in #adipose tissue.
FREE TO READ: nature.com/articles/s42255-0…
The first roadmap toward a consensus atlas of human and mouse adipose tissue is now out in @NatMetabolism! A collaborative effort by the @humancellatlas Adipose Tissue Bionetwork. Glad to have contributed to this valuable resource for the adipose research community – at Campinas, Brasil
Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution go.nature.com/43rCoet
In a major initiative led by Brazilian researchers to test reproducibility in biomedical studies, only 21% of experiments were successfully replicated 🤯. Check out the article and my comment on it! 👇🏻 – at Campinas, Brasil
In an unprecedented effort, a coalition of more than 50 research teams has surveyed a swathe of Brazilian biomedical studies to double-check their findings — with dismaying results
go.nature.com/4cKM9Yk
Marcelo A. Mori retweeted
After we reach advanced age, around 80, the propensity to develop cancer is markedly reduced. A discovery reported @Nature today about aged stem cells and iron insufficiency may help explain this advantage
nature.com/articles/d41586-0… @NatureNV
nature.com/articles/s41586-0…
Marcelo A. Mori retweeted
Checkout our latest publication . Here we describe the functions of LXRs isoforms in adipose tissue macropohages both under lean and obsogenic conditions!
onlinelibrary.wiley.com/doi/…
Groundbreaking discoveries revealing how obesity triggers epigenetic changes in adipose tissue, creating a 'memory' that makes maintaining a healthy weight after weight loss even more challenging
Nature research paper: Adipose tissue retains an epigenetic memory of obesity after weight loss go.nature.com/4eJizC8
Marcelo A. Mori retweeted
One of the reasons why it is so difficult to maintain weight loss is because adipose issue retains an epigenetic memory of obesity after weight loss.
nature.com/articles/s41586-0…
Cool paper from the Treebak lab showing how DICER is quickly downregulated in adipose tissue upon diet-induced obesity and in humans with obesity, representing a hallmark of metabolic dysfunction – at Campinas, Brasil
Happy to share our latest work by Søren Madsen and Augusto Peluso! A huge thanks to everyone involved @Metabolcenter and beyond 👍🙏
Rapid downregulation of DICER is a hallmark of adipose tissue upon high-fat diet feeding sciencedirect.com/science/ar…
Thrilled to have been invited to give a talk at the 9th Internacional Cell Senescence Association (@ICSA_senescence) Conference in Puerto Varas, Chile. Amazing meeting - great science, great people, in an incredible venue. Hope to be back next year in Rome – at Puerto Varas, Chile
