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NIASCEND | Dr. Dmitry Kats

@NIASCEND

Epid @UNCpublichealth | Biostats @usfcoph | Math/CS @XavierU | Biochem @TulaneCBE || 🚀 Ascending beyond just healthy aging mandates https://teapawt.org/t.co/JE2bhVjCml 💎

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pubmed.ncbi.nlm.nih.gov/?term=Kats+Dmitry
Joined October 2023
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND4h
Replying to @NIASCEND @canozoonosity @JohnsHopkins @ARPA_H @Nature
Trillions wasted into AI drug discovery isn’t solving disease but simply accelerating biopharma’s ongoing cash grab for patentable downstream analogues. It is deeply concerning that @Google for one is co-conspiring in fraud, this naive, or under coercion? share.gemini.google/VWUcV0MP…
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
NA proves it’s the ONLY NAD choice BY the flush—not balk but SIGN of enough potential energy flux as NAADP through NAD/NADP for excess energy expenditure vs accrual along aging/disease that’s STRONGER than exercise—shaking potential energy out stores—exposing NAM/NMN/NR as futile
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND3h
Replying to @NIASCEND @canozoonosity @JohnsHopkins @ARPA_H @Nature @Google
I will keep going until @Google’s move: share.gemini.google/92aXGT1H… share.gemini.google/20RhHfTr… share.gemini.google/QxQ64oOG… share.gemini.google/XXdMx6Hz… share.gemini.google/HEiafUx6… share.gemini.google/mfvF4CJf… share.gemini.google/5ArvCPzf… share.gemini.google/W53pOALJ… share.gemini.google/FSiMaLTy… Get your 🍿…
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND10h
Replying to @NIASCEND @canozoonosity @JohnsHopkins @ARPA_H
Such^ groundbreaking medical advancements only collect dust in top journals like @Nature. Naturally—like their partners—they prefer the wealth and acclaim per their role in the “racing to find answers” archetype vs. being rendered useless if they ever promoted even mentioned them
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCENDSep 3
Replying to @NIASCEND
As they conveniently "ignored" 99.4 of relatively needed nicotinic acid mass! But don't worry -- because the BRILLIANT investigators at UC Berkeley teamed up with the most advanced AI drug discovery capabilities to provide you the fix for that... you see how they do it? Suckers
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND11h
Replying to @NIASCEND @canozoonosity @JohnsHopkins @ARPA_H
These fundamentals have already been disentangled to realize not just safe, effective but THE CAUSAL intervention, however, there’s no $ in their transparency—whereas merely hyping “next-gen” AI to inevitably lead to rinse-repeat “discovering” futile analogues of them strikes oil
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Imagine when AI consistently generates—not some estimate—but the EXACT causal effect of ANY intervention on ANY outcome possible—down to the VERY DAY it happens! By 2020, I already did. We—@OpenAI, @Merck, & I—seek fellow frontierists ready to lead… 🎯 aging-us.com/article/102916/…
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND10h
Replying to @NIASCEND @canozoonosity @JohnsHopkins @ARPA_H
Don’t let on the one hand my below excerpt go over your head but AI digitizing tryptophan degrading out proteins along pellagra on the other hand charm you realize the exponentially amplified oxidative degradation of tryptophan coupled to niacin’s lack driving protein misfolding
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCENDOct 6
Replying to @NIASCEND @SmartScience
8/9 Historic investigations uncovered ultimately how w/o adequate nicotinic acid supplementation, tryptophan is left exposed for inflammation to accelerate its oxidative degradation along the kynurenine pathway, diminishing the pool left for protein turnover and tissue repair.
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND21h
Replying to @AlanaDLevin
Wonder why…
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCEND10 Dec 2025
Early-life antibiotic dysbiosis impairs microbial tryptophan-nicotinic acid metabolism exacerbating food allergy in adulthood sciencedirect.com/science/ar…
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND21h
Replying to @sharut_gupta @bjing2016 @shuvom_s
That they don’t even realize what tryptophan is for?
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCEND10 Dec 2025
Early-life antibiotic dysbiosis impairs microbial tryptophan-nicotinic acid metabolism exacerbating food allergy in adulthood sciencedirect.com/science/ar…
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCEND21h
Replying to @AlanaDLevin
But not this eh?
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCEND10 Dec 2025
Early-life antibiotic dysbiosis impairs microbial tryptophan-nicotinic acid metabolism exacerbating food allergy in adulthood sciencedirect.com/science/ar…
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile picture
NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Imagine when AI consistently generates—not some estimate—but the EXACT causal effect of ANY intervention on ANY outcome possible—down to the VERY DAY it happens! By 2020, I already did. We—@OpenAI, @Merck, & I—seek fellow frontierists ready to lead… 🎯 aging-us.com/article/102916/…
🤖 Made with AI
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
NA proves it’s the ONLY NAD choice BY the flush—not balk but SIGN of enough potential energy flux as NAADP through NAD/NADP for excess energy expenditure vs accrual along aging/disease that’s STRONGER than exercise—shaking potential energy out stores—exposing NAM/NMN/NR as futile
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile picture
NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
NA proves it’s the ONLY NAD choice BY the flush—not balk but SIGN of enough potential energy flux as NAADP through NAD/NADP for excess energy expenditure vs accrual along aging/disease that’s STRONGER than exercise—shaking potential energy out stores—exposing NAM/NMN/NR as futile
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile pictureNIASCEND | Dr. Dmitry Kats@NIASCENDSep 24
Replying to @NIASCEND @j0ssyoursalad
The [anti-inflammatory] flush [which for those more pellagric from the start is far less hostile coming w/ necessary tryptophans to restore tissue niacin binds to—GPR109A—that grew fried away as a result of decades w/o niacin]—remember—is nothing more than a random “side effect”!
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile picture
NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @NakkulYdav13626 @JohnsHopkins @ARPA_H
I would take HOM3OSTASIS.com/NIASCEND seriously—and monogamously Tryptophan-Nicotinic Acid Metabolism in Patients with Tumours of the Bladder and Kidney pmc.ncbi.nlm.nih.gov/article… Cheers!
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
Image from NIASCEND | Dr. Dmitry Kats (@NIASCEND)
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NIASCEND | Dr. Dmitry Kats retweeted
Stalled Franchise (@rizzosarge) profile picture
Stalled Franchise@rizzosargeOct 27
Replying to @TradesByJacob @CaseySapp
Not cures. But many treatments can get you back to a functional human. Have you tried Niacin therapy? Helped me bigtime in 2020 then they wiped @NIASCEND off the social medias
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Marketing amides over nicotinic acid defies logic. NMN, NR, and NAM start behind, choked by deamidation bottlenecks that can never yield or realize high-level NA flux. Paying a premium for amides buys an inherently throttled pathway that fails where direct NA succeeds.
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NIASCEND | Dr. Dmitry Kats retweeted
NIASCEND | Dr. Dmitry Kats (@NIASCEND) profile picture
NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Mainstream longevity marketing reframed the harmless flush as a structural flaw to push patented, non-flushing amides like NMN & NR, steering public focus away from direct nicotinic acid, locking consumers into fruitless derivative pathways, and hiding the kinetic reality. (1/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Commercial amides hit strict low-capacity NAMPT limits, requiring slow, rate-limited deamidation just to yield free nicotinic acid, meaning they deliver only a weak, metered trickle instead of the uncompromised metabolic surge required for real disease reversal. (2/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
While conventional studies track static, superficial biomarker snapshots, my advanced MCMC-simulated Bayesian joint models of life-course ARIC cohort data—rigorously accounting for non-ignorable attrition—proved uncompromised nicotinic acid flux is completely irreplaceable. (3/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Chronic cellular stress creates an unrelenting metabolic demand for NAD+, rapidly draining and degrading natural tryptophan reserves through inflammatory cascades, leaving cellular engines completely underpowered when patched with dead-end amides. (4/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Achieving complete metabolic restoration requires precise structural pairing: combining direct nicotinic acid with a rare, free-form L- and D-tryptophan fraction where the D-enantiomer acts as a vital kinetic shield against enzymatic degradation. (5/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDOct 28
Replying to @NIASCEND @lulopson @GabiHartaiM @VitalikButerin
Direct nicotinic acid instantly surges the Preiss-Handler pathway, driving high-velocity NAD+ to NAADP+ flux while utilizing the temporary physical flush as the definitive boundary marker proving peak endolysosomal potential energy release and homeostatic mastery. (6/6)
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NIASCEND | Dr. Dmitry Kats retweeted
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NIASCEND | Dr. Dmitry Kats@NIASCENDMay 25
Replying to @dantawfik
Incorrect. ULK1 is totally downstream, subsidiary, just one of many sub proteins dependent on nicotinic acid binding to properly—w/ enough d-tryptophan—modulated GPR109A protein: mdpi.com/1422-0067/21/9/3321 pmc.ncbi.nlm.nih.gov/article… academia.edu/127710430/Nicot… pmc.ncbi.nlm.nih.gov/article…
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