This post is an ASI ("Ask Sauers Inquiries") about biology. I am an expert in biology (especially health) and think many AI people have incorrect takes. For example, I'm confident biology will not be solved within a lifetime
"If you are a student, you have to let go of the idea that you first acquire skills and basic knowledge and then solve problems. The order reverses." Top-down approach to learning for the win!
Tons of bangers and useful advice for undergrads and grad students trying to make sense of how to navigate academia and entering industry in the age of agents in @Tim_Dettmers recent blog.
Highly recommend people read it.
timdettmers.com/2026/09/21/d…
Pranjal Garg retweeted
This explainer video is amazing!
One friend says strawberries are definitely great. Another says they’re likely terrible. A third says apples are probably good. What do you buy? I tested how five LLMs combine hedged and conflicting statements like these to make a choice.
Pranjal Garg retweeted
If AI makes companies more productive and profitable, why are workers losing their jobs instead of working fewer hours?
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Important 🧵from @DavidDecosimo about the disturbing interactions between @AnthropicAI and religious leaders (including @Pontifex), summarising an excellent @nytimes piece by @elizabethjdias (link to article in the 🧵).
The short story is that Anthropic seems to be making a concerted attempt to establish the view that AI systems could be conscious, might suffer, and that their "interests" should be taken into account.
But - consistent with @Pontifex's Encyclical - there are compelling reasons why (silicon, digital) AI systems are not (and cannot be) conscious. These reasons are found within neuroscience and philosophy of mind, not in the techo-chambers of the frontier firms where the mythology of conscious AI is deeply entrenched.
Claude is vanishingly unlikely to be conscious. To think otherwise could be catastrophic for AI regulation, leaves us psychologically defenceless, is profoundly dehumanising, and plays straight into corporate incentives to keep the AI bubble inflated.
More here, in this @berggruenInst prize winning essay: noemamag.com/the-mythology-o…
This is deeply disturbing:
Anthropic secretly invited religious leaders to SF to advise them on AI safety, had them sign NDAs, but then primarily tried to convince them Claude has a soul & moral standing, all while wining & dining them to the max. 1/ tinyurl.com/preview/296b5z8z
Pranjal Garg retweeted
I think interpretability is ultimately the path to solve the technical parts of the alignment problem - @eric_ho's post on this vision is really worth a read
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Over/under on how many Environmental Health & Safety slide decks the garage lab photo is now in?
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med students: we just want attendings to not bully us
AI people: we have just the thing -- here is a 3D radiology program u didn't ask for
GPT-6 Astra just solved a problem medical students have been facing for decades
Medical students have been working around the same three problems for decades. Someone talked to them, identified all three, and built a service with Astra that solves them in one tool.
The problems are structural. Flat anatomical diagrams strip depth out of organs entirely. CT cross-sections don't connect naturally to the overview diagrams students spend years memorizing. And reading a scan requires holding three mental models simultaneously - patient orientation, cross-section direction, and how every organ shape shifts through each layer.
Astra built a service that handles all three in one place. Not a better textbook. A spatial tool that connects the diagram, the CT view, and the 3D relationship together.
Medical education hasn't changed its core format in over a century. This might be the first tool designed around how anatomy is actually understood - not just displayed.
Pranjal Garg retweeted
Seriously, the more I think about this, the angrier I get. If a trillion-dollar company gets wind of the fact that you're close to a career-defining result, they can dispatch a team, equipped with a private model that has been trained on everything that's ever been publicly . . .
Pranjal Garg retweeted
The amount of basic research done in industry is nowhere near the amount done in universities.
At various times, there have been industry labs that had fundamental research activities and have made important scientific contributions.
Examples in information technology include Bell Labs, IBM Research, Xerox PARC, GE, Phillips, NEC, and several other. That disappeared in the 1990s.
Microsoft Research picked up the torch in the 2000s, followed (to some extent) by Google and then Meta (for about a decade until recently).
But their innovations almost always built on top of academic work, and certainly profited from the whole research ecosystem.
Pranjal Garg retweeted
Whereas AI bros who have never grown cells in a dish are better credentialed than biologists about biology, and their promises of curing all disease in 5 years with robots and AI should be believed 🙄
This is exactly the kind of scientific credentialism that has done so much damage to science.
Doudna won a Nobel Prize for work on bacterial CRISPR systems that enabled gene editing. That does not make her an authority on artificial intelligence, deep learning, or the future of computational biology.
A Nobel Prize is not an all-access pass to pontificate on every scientific field.
Notice what is missing from her argument: any evidence that she understands the current state of AI models, foundation models, reinforcement learning, or where the field is headed. Instead, we are told to accept her conclusion because she won a Nobel Prize.
The claim that biology is too hard is particularly strange. That’s precisely why better computation matters. Nobody serious thinks today’s LLMs are independently curing disease. The question is whether increasingly capable AI, combined with better biological data, automated experimentation, and mechanistic insight from scientists, will transform biomedical discovery.
The answer is almost certainly yes.
The limiting factor is that biology remains one of the most data-starved and experimentally constrained sciences. As those constraints disappear, AI will become increasingly powerful.
The biggest mistake here is assuming that because today’s systems haven’t solved biology, tomorrow’s won’t either.
Scientists should know better than to extrapolate technological progress from a snapshot in time.
Pranjal Garg retweeted
Repeatedly Asking Chatbots “Does She Like Me Back?” Gives
Them Generalized Anxiety Disorders
PDF: immaterialscience.org/s/Chat…
Pranjal Garg retweeted
This is the type of slop blowing up the number of submissions to conferences, screwing up the review process and wasting reviewers' time, and furthering the stochasticity of acceptances.
Such a great evening to start a brand new research for NeurIPS in 3.5 days.🧘♂️
Day 1: planning.
Night 1: running experiments and sending the abstract.
Day 2: reading results fighting with Claude, and sending again.
Night 2: sleep (optional).
Day 3: opening Codex, and finally, write the pape in parallel.
Night 3: resolving the “beef” with Claude (temporary peace) and going to sleep.
Day 4: final reading, last-minute fixes, submission then some relaxation, maybe a beach walk.
I’ll keep you posted on the results.
This will be my only single-author paper, so I can’t hide behind other submissions if it gets rejected 😅
Pranjal Garg retweeted
The irony is that the person who wrote this post got AI to write it so didn't put the cognitive effort into it ... the collapse is clearly happening!
MIT's Nobel Prize-winning economist just published a model with one of the most alarming conclusions in the AI literature so far.
If AI becomes accurate enough, it can destroy human civilization's ability to generate new knowledge entirely.
Not gradually degrade it. Collapse it.
The paper is called AI, Human Cognition and Knowledge Collapse.
Authors: Daron Acemoglu, Dingwen Kong, and Asuman Ozdaglar. MIT. Published February 20, 2026.
Acemoglu won the Nobel Prize in Economics in 2024. He is not a doomer blogger. He is the most cited economist of his generation, and his models tend to be taken seriously by the people who set policy.
Here is the argument in plain terms.
Human knowledge is not just a collection of facts stored in individuals. It is a living system that requires continuous reproduction. People learn things. They apply them. They teach others. They build on prior work to generate new work. The entire engine of science, medicine, technology, and innovation runs on this cycle of active human cognition.
What happens when AI provides personalized, accurate answers to every question people would otherwise have to learn themselves?
Individually, each person is better off. They get correct answers faster. They make fewer errors. Their immediate outcomes improve.
But they stop doing the cognitive work that sustains the collective knowledge base.
Acemoglu's model shows this produces a non-monotone welfare curve.
Modest AI accuracy: net positive. AI helps at the margin, humans still do enough learning to sustain collective knowledge, everyone gains.
High AI accuracy: net catastrophic. AI is accurate enough that learning yourself feels unnecessary. Human learning effort collapses. The knowledge base that AI was trained on is no longer being refreshed or extended. Innovation stalls. Then stops.
The model proves the existence of two stable steady states.
A high-knowledge steady state where human learning and AI assistance coexist productively.
A knowledge-collapse steady state where collective human knowledge has effectively vanished, individuals still receive good personalized AI recommendations, but the shared intellectual infrastructure that enables new discoveries is gone.
And the transition between them is not gradual.
It is a threshold effect. Below a certain level of AI accuracy, society stays in the high-knowledge equilibrium. Above that threshold, the system tips. And once it tips, the collapse is self-reinforcing.
Because the people who would have learned the things that would have pushed the frontier forward never learned them. And the AI cannot push the frontier on its own. It can only recombine what humans already knew when it was trained.
The dark irony at the center of the model:
The AI does not fail. It keeps giving accurate, personalized, useful answers right through the collapse.
From the individual's perspective, nothing looks wrong. You ask a question, you get a correct answer.
But the collective capacity to ask questions nobody has asked before, to build the frameworks that generate new knowledge rather than retrieve existing knowledge, that capacity is quietly disappearing.
Acemoglu has been the most prominent mainstream economist skeptical of transformative AI productivity claims. His prior work found that AI's actual measured productivity gains were much smaller than the technology industry projected.
This paper is a different kind of warning. Not that AI will fail to deliver promised gains.
But that if it succeeds too completely, it will undermine the human cognitive infrastructure that makes long-run progress possible at all.
The welfare effect is non-monotone.
That is the sentence worth sitting with.
Helpful until it is not. Beneficial until it crosses a threshold. And past that threshold, the same accuracy that made it so useful is precisely what makes it devastating.
Every student who uses AI instead of working through a problem is a data point.
Every researcher who uses AI instead of developing intuition is a data point.
Every generation that grows up with accurate AI answers and no incentive to develop deep domain knowledge is a data point.
Individually rational. Collectively catastrophic.
Acemoglu proved this is not just a cultural concern or a vague anxiety about screen time.
It is a mathematically coherent equilibrium that a sufficiently accurate AI system will push society toward.
And there is no visible warning sign before the threshold is crossed.





































