
Interests: #GvHD, #TCT & hematologic disorders, emphasis on Multiple Myeloma, Cancer Patient, also at @plmbuffalo.bsky.social @plmbuffalo@threads.net
Buffalo
Joined January 2012
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Philip McCarthy retweeted
Immune effector cell-associated enterocolitis (IEC-EC) post-BCMA directed CAR T-cell therapy rdcu.be/fg6m1
➡️Incidence 4.6%, late onset (median ~81d)
➡️severe diarrhea/colitis (84% grade ≥3), bowel perforation or pneumatosis (32%)
➡️Rx responses poor and heterogeneous, specially if no response to steroids, 1/3 improved, 1/3 persistent s/s, 1/3 died w bowel complications
➡️No clear association with ALC=hard to predict & pre-empt
➡️Often normal appearance on EGD (see supplementary)
➡️All pts with severe ongoing diarrhea post CAR T should get EGD w random biopsy (duodenum), histopathology eval, and TCR clonality studies. It seems harder to treat than GI GvHD.
#MMSM #CART #Medtwitter @BloodCancerJnl
Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer | Science Immunology science.org/doi/10.1126/scii…
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Philip McCarthy retweeted
Next-generation CAR-T therapy for acute myeloid leukemia: bridging innovation with clinical translation link.springer.com/article/10… #AML #leusm
Scientists Can Now Read Your Body Clock From a Single Hair scitechdaily.com/scientists-…
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Philip McCarthy retweeted
I guess the next-gen cell therapies are here. Really cool paper in @NatImmunol
Engineering NK and T cells with metabolite-sensing receptors to target solid tumors
nature.com/articles/s41590-0…
Philip McCarthy retweeted
Congrats @MattReesMD et al for getting this to finish line!
Link to @AjHematology paper:
onlinelibrary.wiley.com/doi/…
Philip McCarthy retweeted
#Myeloma Paper of the Day: Telomere length (LTL) and clonal hematopoiesis (CH) interact to influence outcomes in hematopoietic stem cell transplantation for myeloma, w/ longer LTL being associated with increased PFS amongst patients without CH: pubmed.ncbi.nlm.nih.gov/4186…. #mmsm
Philip McCarthy retweeted
God help us. This is disgraceful language coming from a Christian, or anyone with a soul. It was just as wrong to celebrate the death of Charlie Kirk as it is to celebrate that of Robert Mueller. May they rest in peace. And may we never forget that Jesus's message is about mercy.
Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer | Science Advances science.org/doi/10.1126/scia…
IL-7/IL-15/IL-21 cytokine-fusion scaffold generates highly functional CAR T cells enriched in long-lived T memory stem cells | Science Advances science.org/doi/10.1126/scia…
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Philip McCarthy retweeted
Private equity firms bought 500 hospitals. Death rates in their emergency rooms went up 13%. They fired 12% of the staff. Then they paid themselves billions in dividends.
A Harvard study just confirmed what doctors already knew: people are dying so investors can hit quarterly targets.
Exactly what happens. A PE firm buys a hospital using debt. The debt gets placed on the hospital's balance sheet, not the firm's. Now the hospital owes hundreds of millions it never borrowed. To service that debt, the hospital cuts costs. Costs mean nurses.
The numbers from the Harvard/University of Chicago study are horrifying. After PE acquisition, emergency department salary spending dropped 18.2%. ICU salary spending dropped 15.9%. Hospital-wide employees were cut 11.6%. Emergency department deaths rose 13%, seven additional deaths per 10,000 visits.
A separate study found patients undergoing surgery at PE-acquired hospitals had 17% higher odds of dying within 90 days.
Steward Health Care, owned by Cerberus Capital, filed bankruptcy with $9 billion in debt after closing hospitals across Massachusetts. The CEO lived on a $40 million yacht while emergency rooms went dark. Eight hospitals serving 2 million people nearly disappeared because a PE fund extracted more cash than the system could survive.
The private equity industry has poured over $1 trillion into healthcare. They operate a quarter of ERs nationwide. This isn't going away.
The investing angle nobody talks about.
Non-PE hospital operators like HCA Healthcare (HCA) and Tenet (THC) are the direct beneficiaries. Every time a PE hospital closes or deteriorates, patients flow to the nearest competitor. HCA has returned 1,200% since 2011. Patient volume from PE closures is a structural tailwind nobody's pricing in.
Medical staffing firms (AMN Healthcare, Cross Country) charge premium rates specifically because PE hospitals cut staff. The staffing shortage IS the business model for these companies.
The disruption play: outpatient surgical centers (SCA Health, now part of UnitedHealth) are pulling profitable procedures out of hospitals entirely. PE-owned hospitals lose their highest-margin surgeries to outpatient, and the death spiral accelerates.
Pull up tradevision and monitor healthcare M&A alerts, hospital closure filings, and patient volume migration data. When a PE-owned hospital announces "restructuring," the patient volume shift to competitors like HCA starts within 30 days. That 30-day window is when the competitor's earnings revisions haven't updated yet. Free to try.
(a private equity firm bought your local hospital. borrowed $500 million in the hospital's name. fired 12% of the nurses. emergency room deaths rose 13%. then they paid themselves dividends. nobody went to prison. they're currently buying another hospital.)
Autologous Hematopoietic Cell Transplantation (AHCT) for the Treatment of Newly Diagnosed Multiple Myeloma - Clinical Lymphoma, Myeloma and Leukemia clinical-lymphoma-myeloma-le…
Philip McCarthy retweeted
Oral Mezigdomide Regimen Looks Promising for R/R Multiple Myeloma cancertherapyadvisor.com/new…















