Pavlos Myserlis (@PMyserlis) header
Pavlos Myserlis (@PMyserlis) profile picture

Pavlos Myserlis

@PMyserlis

Assistant Professor of Neurology @WashUNeurology |@BIDMChealth @MuscNeurology @CGM_MGH @broadinstitute | Stroke genomics & epi | tweets=my own | RT=/endorsement

 St Louis, MO
scholar.google.com/citations?user=htEQFZUAAAAJ&hl=en
Joined November 2013
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Photo by Pavlos Myserlis (@PMyserlis)Photo by Pavlos Myserlis (@PMyserlis)Photo by Pavlos Myserlis (@PMyserlis)Photo by Pavlos Myserlis (@PMyserlis)Photo by Pavlos Myserlis (@PMyserlis)Photo by Pavlos Myserlis (@PMyserlis)Photo by Pavlos Myserlis (@PMyserlis)Photo by Pavlos Myserlis (@PMyserlis)
Truly honored to receive the 2025 S. Weir Mitchell Resident-Fellow Research Award by @AANmember for our work on adiposity and CVD risk. Grateful to my mentors, collaborators and residency program for their support and contributions, and to AAN for recognizing our work.
Image from Pavlos Myserlis (@PMyserlis)
Image from Pavlos Myserlis (@PMyserlis)
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Although common vascular risk factors were the predominant mediators in the GFAT-CVD axis, adiponectin and leptin mediated a proportion of IS and CAD risk.
Image from Pavlos Myserlis (@PMyserlis)
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Our result support a protective role of GFAT in CVD risk. While this is predominantly mediated by common vascular risk factor modification, adipose tissue-specific factors may exert a mediatory effect, suggesting a possible novel target for attenuating adiposity-related CVD risk.
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Thank you to all co-authors for the wonderful collaboration! @MariosGeorgakis @emayerho @Murad__Omarov @JRosand_MD @drcbanerjee @CDAndersonMD
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The protective role of GFAT volume was also evident in our positive controls, CAD, MRI-confirmed lacunar stroke, and carotid IMT.
Image from Pavlos Myserlis (@PMyserlis)
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Our paper exploring the association between BMI-independent adipose tissue burden and CVD risk is now out in @GreenJournal ! A few highlights: neurology.org/doi/10.1212/WN…

A Beneficial Role for Gluteofemoral Adipose Tissue in Cerebrovascular Disease | Neurology

Background and ObjectivesPrevious studies have shown that increased body fat is associated with stroke risk, with evidence suggesting that body fat distribution, rather than total body fat, exerts a...

neurology.org
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Using Mendelian randomization (MR), we found that genetic predisposition to higher gluteofemoral adipose tissue (GFAT) volume was associated with lower risk of ischemic stroke, LAS, and SVS (A), consistent in multivariable MR analyses (B).
Image from Pavlos Myserlis (@PMyserlis)
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@dpsg108 @MariosGeorgakis @JRosand_MD @drcbanerjee @CDAndersonMD @MuscNeurology
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Glad to present Grand Rounds this past week to my Residency Program @MuscNeurology, followed by great discussion afterwards! Glad to see people getting engaged in this rapidly developing area. Grateful to all my mentors, PD, and APDs, and excited for the next steps coming ahead!
Image from Pavlos Myserlis (@PMyserlis)
Image from Pavlos Myserlis (@PMyserlis)
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#ISC25 great science and opportunity to learn and connect.. #MUSC_stroke. @AbuQdaisA @PMyserlis @AWabnitzMD @MuscNeurology @muscmind
Image from Ghada A Mohamed. (@GhadaMohamedMD)
Image from Ghada A Mohamed. (@GhadaMohamedMD)
Image from Ghada A Mohamed. (@GhadaMohamedMD)
Image from Ghada A Mohamed. (@GhadaMohamedMD)
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Hot Off Press: AF patients with stroke due to symptomatic atherosclerosis have high stroke recurrence, hemorrhagic events, and mortality rates. Combination sAC+sAP may reduce short-term stroke recurrence but increase the hemorrhagic risk in the long term.sciencedirect.com/science/ar…
Image from Ghada A Mohamed. (@GhadaMohamedMD)
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The HERMES 24 score, published in @StrokeAHA_ASA, could be useful for counseling patients and families on the chances for favorable or unfavorable outcome. Although it may overemphasize clinical status at 24 hrs; delayed recovery is important @ESOstroke @WorldStrokeOrg
Image from Seemant Chaturvedi (@ChaturvediNeuro)
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Is IL-6 signaling always bad❓ Our recent study with @PMyserlis @AnushreeRay4 @CDAndersonMD tests if 🧬genetic proxies for IL-6 signaling downregulation are linked to 1⃣Alzheimer's disease 2⃣lobar intracerebral hemorrhage (cerebral amyloid angiopathy)🧠 alz-journals.onlinelibrary.w…
Image from Marios Georgakis (@MariosGeorgakis)
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Glad to share our pre-print investigating the role of BMI-independent adipose tissue distribution profiles on cerebrovascular disease (CVD) risk, using large-scale genomics data! medrxiv.org/content/10.1101/… A summary of our key results:
The role of the gluteofemoral adipose tissue in cerebrovascular disease risk: evidence from a...

The role of the gluteofemoral adipose tissue in cerebrovascular disease risk: evidence from a...

Objective To explore causal associations between BMI-independent body fat distribution profiles and cerebrovascular disease risk, and to investigate potential mediators underlying these associations....

medrxiv.org
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- While the protective role of GFAT on CVD risk is mediated predominantly by common vascular risk factor modification (SBP, T2DM, LDL), residual mediatory effect may be exerted by adipose-specific factors, suggesting that targeting those may provide additional vascular benefit
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Thanks to all co-authors and collaborators! @MariosGeorgakis @livia_parodi @emayerho @drcbanerjee @JRosand_MD @CDAndersonMD
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🚨Postdoc Opening🚨 We're seeking a skilled scientist to lead research in multiomics❗️ Join our excellent interdisciplinary team👇in our efforts to tackle pressing challenges in cardiovascular disease Lab: georgakis-lab.isd-muc.de Position: findapostdoc.com/search/Job-… Please RT!
Image from Marios Georgakis (@MariosGeorgakis)
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Deeply honored to receive the Resident Research Scholarship and the Resident Scholarship to the Annual Meeting by @AANmember! Immensely grateful to my mentors @drcbanerjee, @CDAndersonMD, and to my PD @yamadalbc for all their support! Thank you @AANmember for funding our work.
Image from Pavlos Myserlis (@PMyserlis)
Image from Pavlos Myserlis (@PMyserlis)
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Pavlos Myserlis retweeted
David Seiffge (@DavidSeiffge) profile picture
David Seiffge@DavidSeiffge19 Mar 2024
Secondary stroke prevention in people with AF - published ⁦@TheLancetNeuro⁩! fantastic team work @caso_valeria⁩ ⁦@RaberLorenz⁩ ⁦@FishingNeurons⁩ ⁦@UCLStrokeRes⁩ ⁦@Ash_Shoamanesh⁩ ⁦@ESOstroke⁩ ⁦@StrokeBern⁩ authors.elsevier.com/a/1inIG…
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