Physician Scientist at Regeneron Genetics Center @RegeneronDNA
Cambridge, MA / Tarrytown, NY
Joined September 2021
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Ernst Mayerhofer retweeted
Enhanced risk stratification for anticoagulation-related intracerebral hemorrhage 💊🩸 is achieved with the use of a genetic risk score 🧬.
Recently published in @StrokeAHA_ASA
Get to know more at ⬇️
ahajournals.org/doi/10.1161/…
@emayerho @livia_parodi @CDAndersonMD
Ernst Mayerhofer retweeted
Delighted to contribute to this paper led by @emayerho showing that CHIP is enriched among young pts presenting with strokes of unknown etiology, including how CHIP testing changed the management for a subset of patients ahajournals.org/doi/10.1161/… @StrokeAHA_ASA
#OriginalResearch: Prevalence and Therapeutic Implications of Clonal Hematopoiesis of Indeterminate Potential in Young Patients With #Stroke #AHAJournals ahajrnls.org/3InXvEc @JRosand_MD @CDAndersonMD @pnatarajanmd @mgeorgakis1 @emayerho @Heiko__Becker
ALT Graphic abstract in Mayerhofer et al.
Ernst Mayerhofer retweeted
Can polygenic scores be used in clinically relevant scenarios? Have a look at our @StrokeAHA_ASA paper by @emayerho @CDAndersonMD, where we show that adding a PRS for ICH to HAS-BLED in patients under anticoagulation improves risk stratification for ICH ahajournals.org/eprint/5D6QG…
Happy to share our most recent work on PRS in ICH demonstrating how genetics can improve prediction in a clinical setting. Thanks to @CDAndersonMD @mgeorgakis1 @JRosand_MD @rainermpg et al for amazing mentorship!
Check our preprint with @emayerho @CDAndersonMD on a polygenic risk score for #ICH that when incorporated into a clinical score proxying HAS-BLED improves prediction for ICH among #anticoagulant-users. A window for a direct clinical application of #PRS? medrxiv.org/content/10.1101/…
Ernst Mayerhofer retweeted
Just out! 📢 📢 📢
The largest study on stroke genetics 🧬 with more than 2M individuals (incl. >200,000 cases) just published in @Nature!
Have a look here 👉 nature.com/articles/s41586-0…
🧵1/7
Ernst Mayerhofer retweeted
Glad to share our work highlighting the importance of treating uncontrolled BP in ICH survivors irrespective of hemorrhage location published in the official journal of @ESOstroke
journals.sagepub.com/doi/10.…
Ernst Mayerhofer retweeted
While the benefits of statins for preventing vascular disease are well-established, Mayerhofer et al. show that genetic factors influencing the response to statins are also associated with risk for intracerebral haemorrhage. bit.ly/3PBAbV1
Ernst Mayerhofer retweeted
Have a look at our Mendelian randomization study exploring the effects of genetically predicted on-statin LDL response on risk of ICH that just came out in @Brain1878 @emayerho @CDAndersonMD @rainermpg @stevesphd @CGM_MGH @broadinstitute @MGHBrainHealth
academic.oup.com/brain/advan…
Ernst Mayerhofer retweeted
ICYMI: "Genetically predicted on-statin LDL response is associated with higher intracerebral hemorrhage risk" led by @emayerho and @mgeorgakis1 at medRxiv: medrxiv.org/content/10.1101/…. Not the first example of this approach I've seen, but a really interesting one. Thread follows!
I am happy to share our recent work on statins and intracerebral hemorrhage that illustrates how genetic variation of drug response can be used to assess drug effects. Many thanks to @mgeorgakis1 @cdandersonmd @rainermpg @jrosand_md @stevesphd and others medrxiv.org/content/10.1101/…
I am excited to share an article published today in Frontiers in Neurology, on which I have worked during the last three years. Thanks to @cdandersonmd and all other contributors! frontiersin.org/articles/10.…
Ernst Mayerhofer retweeted
Many thanks to all the co-authors @CDAndersonMD @JRosand_MD @emayerho @jpirruccello @rainermpg @ISD_Research and everybody else not on twitter and acknowledgements to @dfg_public for funding my stay in Boston
Ernst Mayerhofer retweeted
glad to share our article on the genetics of cryptogenic stroke in Annals of Neurology doi.org/10.1002/ana.26332 reflecting my work @CGM_MGH @broadinstitute Main message: genetics don't respect our diagnostic boundaries
