Yale chembio postdoc. Formerly UCLA, Oxford Uni (PhD) & Durham Uni (MSci). Also formerly Salford Uni (MA Music) & Wadham College graduate music scholar.
Los Angeles, CA
Joined February 2012
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Very pleased to share that my PhD work from @UniofOxford/@synbioCDT with @conway_group is now live on BioRxiv - we designed pairs of orthogonal IMiD analogues and ZF degrons for use in target validation & beyond. biorxiv.org/content/10.1101/…
Patrick Brennan retweeted
Our paper reporting the discovery of a selective molecular glue degrader of the transcription factor FIZ1 is now online in @J_A_C_S. Read more here: pubs.acs.org/jacsat/article/…
This was collaborative work with Heeseon An's lab @MSKCancerCenter! #TPD #MolecularGlues #ChemBiol
Patrick Brennan retweeted
5-tBu-Thalidomide
Is a Selective Molecular Glue Degrader of the Transcription Factor
FLT3 Interacting Zinc Finger 1 (FIZ1) pubs.acs.org/jacsat/article/…
Patrick Brennan retweeted
Sometimes single-minded dedication to a problem is the path to great science. I’ve never met someone more focused on a problem than David Baker. Among the postdocs at UCSF in the early ‘90s, none of us would have been surprised to learn there was a Nobel Prize in David’s future.
Patrick Brennan retweeted
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
Patrick Brennan retweeted
Nature's guide on how to write effective abstracts
ALT Nature's guide on the sections and structure of an effective scientific abstract.
Patrick Brennan retweeted
We have been blown away by all the wonderful messages that we have received in response to our symposium! Thank you! It means a lot to all of us that our delegates had a fantastic time in Dundee and have left inspired to push forward the frontiers of TPD research!
#TPDFocus
ALT Group of people sat in a full lecture theatre
Had a really wonderful time at @UoDCeTPD #TPDFocus conference in Dundee, huge congratulations to @alessiociulli & all organisers for putting on such a fantastic event & the official opening of your ‘House of VHL’! Also great to put so many faces to names I’d cited in my thesis!
Really enjoying @tameimpala ‘s new album - their poppiest yet. Genius move to have @DUALIPA on vocals
Patrick Brennan retweeted
Looking forward to a double act with @PatrickJosephB on Thursday for the TPD Webinar!
Join our next TPD Webinar, 2nd May, 11AM EDT/ 8AM PT/ 4PM BST / 5PM CEST
@conway_group, @PatrickJosephB - 'Bringing Bump-and-Hole to Molecular Glues: The Development of Orthogonal IMiD-Degron Pairs'
@DianeHaakonsen - 'Stress Response Silencing in Neurodegenerative Disease'
Patrick Brennan retweeted
Join our next TPD Webinar, 2nd May, 11AM EDT/ 8AM PT/ 4PM BST / 5PM CEST
@conway_group, @PatrickJosephB - 'Bringing Bump-and-Hole to Molecular Glues: The Development of Orthogonal IMiD-Degron Pairs'
@DianeHaakonsen - 'Stress Response Silencing in Neurodegenerative Disease'
Patrick Brennan retweeted
Losing Oxford rower reveals he and several others in the boat were struck down with E. coli this morning, apparently from shit in the river. The Boat Race is being watched around the world. The current state of our waterways is an international disgrace and embarrassment.
Patrick Brennan retweeted
Really lovely and meticulous work, @conway_group, using a similar IMiD bump to avoid off-target degradation. It’s possible or even likely that SD40 will interface well with your IMiD, given the relatedness between compound 23 and PT-179, and how the latter is bound in the CRBN•SD40 complex. Hopefully our two studies can appear together in print in @ScienceMagazine. @dijiang319
Work is currently under review - we decided to post a preprint after seeing the excellent work by @davidrliu, @fischerlab1 & @ChoudharyLab who used continuous evolution to engineer the previously reported superdegron for use with a reduced off-target IMiD science.org/doi/abs/10.1126/…
Very much looking forward to showcasing this work at the Targeted Protein Degradation in Focus symposium at @UoDCeTPD in May, as well as seeing first hand all the other excellent work being conducted in this field
Patrick Brennan retweeted
Having enjoyed the paper from @davidrliu, @fischerlab1, and @ChoudharyLab in @ScienceMagazine this week, we have now posted our own, complementary, taken on a bump-and-hole approach to develop an orthogonal bumped IMiD-degron pair: biorxiv.org/content/10.1101/….
