@Plate_Lab

Developing mass spectrometry and chemical biology tools to study dynamic protein interactions at @VanderbiltChem. This is a trainee run account.

 Nashville, TN
plate-research.org/
Joined March 2019
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65Media
Excited to share a preprint from @J_P_Davies PhD work! We find that CoVs, like SARS-CoV-2, use malectin (part of cells’ glycoprotein production assembly line) to make viral proteins and replicate. Malectin may be a prime pan-CoV antiviral target! 🧵(1/7) biorxiv.org/content/10.1101/…
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MLEC surveys our glycoproteins during production, checking for errors and capturing duds before they are sent out. Is this function of MLEC important for CoV replication? Yes! (6/7)
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Lastly, is MLEC important for SARS-CoV-2 replication? We use a replicon system to show that YES, it is! (7/7)
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Congratulations @EliFritzMcD !
Vanderbilt Center for Structural Biology@VanderbiltCSB10 Nov 2023
Congratulations to @EliFritzMcD (of the @MeilerLab & @Plate_Lab) on winning the 2024 Karpay Award in Structural Biology! Eli presents "CFTR Folding – Started from the Translocon Now We Here" on Tuesday, January 23, 2024, for the MBTP/CSB Seminar Series. bit.ly/3ufN00S
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Good morning Phoenix. Looking forward to attending #NACFC2023. If you’re around, come to the lunch roundtable on Proteomic-driven Advances in Studies of CF (RT29) where we’ll discuss the latest mass spec research on CF. @CF_Foundation
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Can #AlphaMissense identify Cystic Fibrosis causing variants? We benchmarked AM pathogenicity predictions on CF clinical outcomes from the CFTR2.org database and CFTR in vitro data. @EliFritzMcD @MeilerLab Here's what we found: 🧵(1/7) biorxiv.org/content/10.1101/…
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Finally, we were curious if AM could predict CFTR theratype - how CFTR variants respond to drug. This feat is technically outside AM's intended design, but is important in the CF field. We concluded, AM cannot predict CFTR theratype. (6/7)
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In sum, AM predicts CF accurately w/ a high false positive rate. AM correlated modestly w/ clinical outcomes, but well w/ CFTR function. It cannot distinguish pathophysiology. AM may prove useful for identifying CF causing variants in carriers, but caution must be taken. (7/7)
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Congrats @Dongsheng_Han1 and @JaredNordman! Glad that @J_P_Davies and our lab could contribute to this exciting paper.
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Follow @J_P_Davies’s research activities in Peru: – at Nashville, TN
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We concluded translational dynamics modulate the co-translational folding of P67L sufficiently to sensitive it to VX-445. Personalized medicine will need to account for system level changes beyond single point mutations in targets.
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Attenuating global translation with low doses of cycloheximide (CHX) also reversed P67L VX-445 response.
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