@Plate_Lab

Developing mass spectrometry and chemical biology tools to study dynamic protein interactions at @VanderbiltChem. This is a trainee run account.

 Nashville, TN
plate-research.org/
Joined March 2019
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  • Followers314
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We concluded translational dynamics modulate the co-translational folding of P67L sufficiently to sensitive it to VX-445. Personalized medicine will need to account for system level changes beyond single point mutations in targets.
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Attenuating global translation with low doses of cycloheximide (CHX) also reversed P67L VX-445 response.
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Ribosomal protein knockdown reversed P67L VX-445 response, sensitizing the mutant to the drug.
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P67L protein interactions change between VX-445 and VX-809, revealing an enrichment of translational proteins.
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Next, we used quantitative interactomics to measure the protein homeostasis network interactions experienced by P67L and L206W under VX-809, VX-661, and VX-445 drug treatment conditions.
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First we demonstrated VX-661 hyper-responsive mutant P67L fails to respond to VX-445 by both trafficking assay and electrophysiology. L206W, by contrast, responds robustly to both drugs.
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The CFTR theratype story thickens with our latest paper. jbc.org/article/S0021-9258(2… We showed attenuating translation sensitizes P67L to respond to VX-445 correction. This implies a previously unknown role for co-translational folding in VX-445 response.
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A collaboration between the @MeilerLab, @Plate_Lab and @schlebac lab (@IUBloomington) characterizes the drug response of 129 CFTR variants using deep mutational scanning. sciencedirect.com/science/ar… @VUBasicSciences @EliFritzMcD @VanderbiltChem @VandyBioGrad
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Anyone interested in the role of RNA and translation in CFTR biogenesis check out this review from the authority in the field
This Post is from an account that no longer exists. Learn more
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To fold or not to fold? That is the question. For CFTR at least! Check our new preprint from the @Plate_Lab demonstrating divergent translational dynamics may predestine rare CFTR mutations to proper folding when treated with #cysticfibrosis drugs. doi.org/10.1101/2023.02.04.5…
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Work from the labs of Chuck Sanders, David Samuels, and the @Plate_Lab point to a series of proteins with segments that are zero- or low-tolerant of missense mutations. medschool.vanderbilt.edu/bas… @VandyBiochem @VanderbiltMPB @VanderbiltChem

Study identifies human proteins with segments devoid of genetic variation

By Leah Mann The lab of Charles Sanders, professor of biochemistry and the Aileen M. Lange and Annie Mary Lyle Chair for Cardiovascular Research, published a study in Protein Science identifying all...

medschool.vanderbilt.edu
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Can #AlphaFold2 predict structures of protein classes for which it was not trained? In my third and final first author paper of 2022, we benchmark #AlphaFold2 on peptide structure prediction. cell.com/structure/fulltext/…

Benchmarking AlphaFold2 on peptide structure prediction

McDonald et al. investigate the performance of AlphaFold2 in comparison with other peptide and protein structure prediction methods. Root-mean-square deviation analyses show deep-learning methods...

cell.com
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Replying to @Plate_Lab
@Plate_Lab attending the @NashvilleSC game last night @J_P_Davies unfortunately it ended in a tie
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Had an energizing and enlightening week talking science in person at @cshlmeetings Protein Homeostasis in Health and Disease Conference with the @Plate_Lab.
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Congratulations to Jonathan Davies for being GSA's Student of the Month for January 2022! Check out Jonathan's interview on our Instagram! #vandybiograd #gsa #scientists #graduateschool
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Congratulations to Caitlin Davis @thedavislab @YaleChem and Lars Plate @Plate_Lab @VanderbiltChem for “Structure-Function of Enzyme Filaments: Regulators of Cell Metabolism in Space and Time.”
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A new paper from @BrianOBachmann @BenjaminReisman identified the F1 sub complex of mitochondrial ATP synthase as the target for a family of glycosylated macrolides, the apoptolidins. Free to read: rdcu.be/cCu1t nature.com/articles/s41589-0…
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Would be super exciting to have a diverse pool of international students to join us in fall 2021!! @VanderbiltChem ! Thank you @alliesw1 @nathandschley @Plate_Lab!
ADSE_VU@AdseVu8 Nov 2021
Our first #ADSE diversity event! Prospective international students chat exclusively with our #vanderbiltchem students @reecan_j @shaoqz @M__Tremblay for a first-hand account of the experience and tips on the app process. These bright minds represent countries the world over!
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Plate Lab retweeted
Prof. SP8@IR_SP822 Oct 2021
Back from the break with a banger! Chemical Biology talk from Madison Wright in the @Plate_Lab
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Stop by our virtual booth today to learn about our PhD program! We are available 10am-1pm CST.
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